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01-10-2020 | Original Article

Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process

Authors: Nandhine Rajasekar, Ayyanar Sivanantham, Amrita Kar, Santanu Kar Mahapatra, Rajesh Ahirwar, Rajesh K. Thimmulappa, Sudhakar Gandhi Paramasivam, Rajasekaran Subbiah

Published in: Inflammopharmacology | Issue 5/2020

Abstract

Pulmonary fibrosis (PF) is a chronic and irreversible scarring disease in the lung with limited treatment options. Therefore, it is critical to identify new therapeutic options. This study was undertaken to identify the effects of tannic acid (TA), a naturally occurring dietary polyphenol, in a mouse model of PF. Bleomycin (BLM) was intratracheally administered to induce PF. Administration of TA significantly reduced BLM-induced histological alterations, inflammatory cell infiltration and the levels of various inflammatory mediators (nitric oxide, leukotriene B₄ and cytokines). Additionally, treatment with TA also impaired BLM-mediated increases in pro-fibrotic (transforming growth factor-β1) and fibrotic markers (alpha-smooth muscle actin, vimentin, collagen 1 alpha and fibronectin) expression. Further investigation indicated that BLM-induced phosphorylation of Erk1/2 (extracellular signal-regulated kinases 1 and 2) in lungs was suppressed by TA treatment. Findings of this study suggest that TA has the potential to mitigate PF through inhibiting the inflammatory response and fibrotic process in lungs and that TA might be useful for the treatment of PF in clinical practice.

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Title: Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process
Authors: Nandhine Rajasekar
Ayyanar Sivanantham
Amrita Kar
Santanu Kar Mahapatra
Rajesh Ahirwar
Rajesh K. Thimmulappa
Sudhakar Gandhi Paramasivam
Rajasekaran Subbiah
Publication date: 01-10-2020
Publisher: Springer International Publishing
Published in: Inflammopharmacology / Issue 5/2020
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-020-00707-5

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Tannic acid alleviates experimental pulmonary fibrosis in mice by inhibiting inflammatory response and fibrotic process

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