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01-02-2019 | Review

Stress as an immunomodulator: liver X receptors maybe the answer

Authors: Issam Nessaibia, Allan Fouache, Jean-Marc A. Lobaccaro, Abdelkrim Tahraoui, Amalia Trousson, Maâmar Souidi

Published in: Inflammopharmacology | Issue 1/2019

Abstract

Stress is a reflex response, both psychological and physiological, of the body to a difficult situation that requires adaptation. Stress is at the intersection of the objective event and the subjective event. The physiological mechanisms involved in chronic stress are numerous and can contribute to a wide variety of disorders, in all systems including the immune system. Stress modifies the Th1/Th2 balance via the HPA axis and a set of immune mediators. This will make the body more vulnerable to external infections in a scientific way while others claim the opposite, stress could be considered immune stimulatory. The development of synthetic LXR ligands such as T0901317 and GW3965 as well as an understanding of the direct involvement of these receptors in the regulation of proopiomelanocortin (POMC) gene expression and indirectly by producing a variety of cytokines in a stressor response, will open in the near future new therapeutic methods against the undesirable effects of stress on the behavior of the immune system.

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Title: Stress as an immunomodulator: liver X receptors maybe the answer
Authors: Issam Nessaibia
Allan Fouache
Jean-Marc A. Lobaccaro
Abdelkrim Tahraoui
Amalia Trousson
Maâmar Souidi
Publication date: 01-02-2019
Publisher: Springer International Publishing
Published in: Inflammopharmacology / Issue 1/2019
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-018-0546-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Stress as an immunomodulator: liver X receptors maybe the answer

Abstract

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

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