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Inflammopharmacology

01-10-2017 | Review

Immunomodulatory basis of antioxidant therapy and its future prospects: an appraisal

Authors: Y. Ajith, U. Dimri, S. K. Dixit, Shanker K. Singh, A. Gopalakrishnan, E. Madhesh, J. B. Rajesh, S. G. Sangeetha

Published in: Inflammopharmacology | Issue 5/2017

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Abstract

Antioxidants are agents which can modulate oxidant–antioxidant profile of body system by neutralizing pro-oxidant molecules. The current scientific knowledge on mechanisms of antioxidant activity of biomolecules was critically reviewed with a special emphasis on immunomodulation. The immuno-oxidative wreckage of animals in various disease conditions and the role of biomodulators in curbing the oxidative stress through immune pathways were analyzed. The critical role of immunomodulatory mechanisms in controlling oxidative damage was identified. Selection of antioxidant therapy considering the immunopharmacology of the drug as well as immunological basis of disease may reduce treatment failure and adverse health effects. Hence, it is suggested that future studies on antioxidants may focus on the immuno-oxidative pathobiology to better understand its clinical effects and effective disease management.
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Metadata
Title
Immunomodulatory basis of antioxidant therapy and its future prospects: an appraisal
Authors
Y. Ajith
U. Dimri
S. K. Dixit
Shanker K. Singh
A. Gopalakrishnan
E. Madhesh
J. B. Rajesh
S. G. Sangeetha
Publication date
01-10-2017
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 5/2017
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-017-0393-5