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European Journal of Pediatrics
Published in: European Journal of Pediatrics 11/2006

01-11-2006 | Original Paper

Protein oxidation in obesity and insulin resistance

Authors: M. Emre Atabek, Mehmet Keskin, Cevat Yazici, Mustafa Kendirci, Nihal Hatipoglu, Esat Koklu, Selim Kurtoglu

Published in: European Journal of Pediatrics | Issue 11/2006

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Abstract

Introduction

Advanced oxidation protein products (AOPP) are considered reliable markers to estimate the degree of oxidant-mediated protein damage. Data on oxidative stress in childhood obesity and insulin resistance are limited.

Objective

The aim of this study was to investigate the AOPP level as an oxidative stress marker in obesity and insulin resistance. The study included 57 pubertal obese children and adolescents (30 girls and 27 boys) and 20 healthy pubertal children and adolescents (11 girls and 9 boys).

Materials and Methods

All participants in the obesity group underwent an oral glucose tolerance test (OGTT) and two separate groups were formed according to the existence of insulin resistance.

Results

AOPP levels were measured in the obesity and control groups spectrophotometrically. The obesity group consisted of 25 children and adolescents with insulin resistance and 32 subjects without insulin resistance. AOPP levels in the obesity group were found to be significantly higher than those in the control group. Although AOPP levels in the subjects with insulin resistance were higher than the subjects without insulin resistance, there was no significant difference between AOPP levels of subgroups with insulin resistance and without insulin resistance.

Conclusion

This study showed protein oxidation in obesity with a novel oxidative stress marker and it also suggests that insulin resistance may play an important role as a source of oxidative stress in the development of other diseases after pubertal years.
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Metadata
Title
Protein oxidation in obesity and insulin resistance
Authors
M. Emre Atabek
Mehmet Keskin
Cevat Yazici
Mustafa Kendirci
Nihal Hatipoglu
Esat Koklu
Selim Kurtoglu
Publication date
01-11-2006
Publisher
Springer-Verlag
Published in
European Journal of Pediatrics / Issue 11/2006
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-006-0165-5

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