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Published in: Inflammation 4/2020

01-08-2020 | Osteoarthrosis | Original Article

Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice

Authors: Wenhan Wang, Ruitong Yang, Minfa Zhang, Jiayi Li, Jiangfan Peng, Mingyang Xu, Yunpeng Zhao, Hao Li, Xin Pan

Published in: Inflammation | Issue 4/2020

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Abstract

Osteoarthritis (OA), a chronic joint disease, is characterized by cartilage surface erosion, subchondral bone rebuilding, and formation of osteophytes. To date, the nosogenesis and underlying mechanisms of OA have not yet been elucidated. However, it is widely accepted that TNF-α is a crucial cytokine in the development of OA. Glycitin, a natural isoflavone extracted from legumes, affects physiological reactions and pathological responses. Recently, the anti-inflammatory effect of glycitin has been reported. However, the function of glycitin in cartilage degeneration in OA remains to be investigated. In the current study, primary murine chondrocytes were isolated and stimulated by TNF-α to evaluate the anti-inflammatory effects and protective function of glycitin in chondrocytes. In vivo, the ACLT mouse model, a frequently-used OA model, was used to further examine the therapeutic role of glycitin in cartilage degeneration and inflammation in OA. Consequently, glycitin functions were examined both in vivo and in vitro. Moreover, the underlying mechanism of action of glycitin was investigated and was found to involve the NF-κB signaling pathway. Collectively, this study suggests that glycitin can be potentially used for the treatment of joint degenerative diseases, including OA.
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Metadata
Title
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice
Authors
Wenhan Wang
Ruitong Yang
Minfa Zhang
Jiayi Li
Jiangfan Peng
Mingyang Xu
Yunpeng Zhao
Hao Li
Xin Pan
Publication date
01-08-2020
Publisher
Springer US
Published in
Inflammation / Issue 4/2020
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-020-01210-3

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