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Inflammation
Published in: Inflammation 2/2016

01-04-2016 | Original Article

Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis

Authors: Jaqueline Beppler, Patrícia Koehler-Santos, Gabriela Pasqualim, Ursula Matte, Clarice Sampaio Alho, Fernando Suparregui Dias, Thayne Woycinck Kowalski, Irineu Tadeu Velasco, Renato C. Monteiro, Fabiano Pinheiro da Silva

Published in: Inflammation | Issue 2/2016

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Abstract

Sepsis is a devastating disease that can affect humans at any time between neonates and the elderly and is associated with mortality rates that range from 30 to 80 %. Despite intensive efforts, its treatment has remained the same over the last few decades. Fc receptors regulate multiple immune responses and have been investigated in diverse complex diseases. FcγRIIA (CD32A) is an immunoreceptor, tyrosine-based activation motif-bearing receptor that binds immunoglobulin G and C-reactive protein, important opsonins in host defense. We conducted a study of 702 patients (184 healthy individuals, 171 non-infected critically ill patients, and 347 sepsis patients) to investigate if genetic polymorphisms in the CD32A coding region affect the risk of septic shock. All individuals were genotyped for a variant at position 131 of the FcγRIIA gene. We found that allele G, associated with the R131 genotype, was significantly more frequent in septic patients than in the other groups (p = 0.05). Our data indicate that FcγRIIA genotyping can be used as a marker of genetic susceptibility to sepsis.
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Metadata
Title
Fc Gamma Receptor IIA (CD32A) R131 Polymorphism as a Marker of Genetic Susceptibility to Sepsis
Authors
Jaqueline Beppler
Patrícia Koehler-Santos
Gabriela Pasqualim
Ursula Matte
Clarice Sampaio Alho
Fernando Suparregui Dias
Thayne Woycinck Kowalski
Irineu Tadeu Velasco
Renato C. Monteiro
Fabiano Pinheiro da Silva
Publication date
01-04-2016
Publisher
Springer US
Published in
Inflammation / Issue 2/2016
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-015-0275-1

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