Top

Published in:

01-06-2015

Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis

Authors: Suqin Zhang, Yuqin Li, Yufeng Liu

Published in: Inflammation | Issue 3/2015

Abstract

IL4 -589C/T polymorphism has been implicated in susceptibility to pediatric asthma risk. Several studies investigated the association of this polymorphism with pediatric asthma in different populations. However, the results were contradictory. A meta-analysis was conducted to assess the association between IL4 -589C/T polymorphism and pediatric asthma risk. Databases including Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wangfang were searched to find relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were used to assess the strength of associations. A significant association was found between IL4 -589C/T polymorphism and pediatric asthma risk (OR = 1.53, 95% CI 1.27–1.85). In the subgroup analyses by ethnicity, the significant association was found among Caucasians (OR = 1.70, 95 % CI 1.38–2.09) and Asians (OR = 1.58, 95 % CI 1.23–2.04). Our results suggested that IL4 -589C/T polymorphism conferred a risk factor of pediatric asthma.

Sandford, A., T. Weir, and P. Paré. 1996. The genetics of asthma. American Journal of Respiratory and Critical Care Medicine 153(6 Pt 1): 1749–1765.CrossRefPubMed

Daher, S., L.M. Santos, D. Solé, M.G. De Lima, C.K. Naspitz, and C.C. Musatti. 1995. Interleukin-4 and soluble CD23 serum levels in asthmatic atopic children. Journal of Investigational Allergology & Clinical Immunology 5(5): 251–254.

Walker, C., W. Bauer, R.K. Braun, G. Menz, P. Braun, F. Schwarz, T.T. Hansel, and B. Villiger. 1994. Activated T cells and cytokines in bronchoalveolar lavages from patients with various lung diseases associated with eosinophilia. American Journal of Respiratory and Critical Care Medicine 150(4): 1038–1048.CrossRefPubMed

Robinson, D.S., Q. Hamid, S. Ying, A. Tsicopoulos, J. Barkans, A.M. Bentley, C. Corrigan, S.R. Durham, and A.B.. Kay. 1992. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. The New England Journal of Medicine 326(5): 298–304.

Renz, H., K. Bradley, K. Enssle, J.E. Loader, G.L. Larsen, and E.W. Gelfand. 1996. Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor. International Archives of Allergy and Immunology 109(2): 167–176.CrossRefPubMed

Zhou, C.Y., I.C. Crocker, G. Koenig, F.A. Romero, and R.G. Townley. 1997. Anti-interleukin-4 inhibits immunoglobulin E production in a murine model of atopic asthma. Journal of Asthma 34(3): 195–201.CrossRefPubMed

Marsh, D.G., J.D. Neely, D.R. Breazeale, B. Ghosh, L.R. Freidhoff, E. Ehrlich-Kautzky, C. Schou, G. Krishnaswamy, and T.H. Beaty. 1994. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264(5162): 1152–1156.CrossRefPubMed

Rosenwasser, L.J., and L. Borish. 1997. Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). American Journal of Respiratory and Critical Care Medicine 156(4 Pt 2): S152–S155.CrossRefPubMed

Walley, A.J., and W.O. Cookson. 1996. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. Journal of Medical Genetics 33(8): 689–692.CrossRefPubMedCentralPubMed

10.

Takabayashi, A., K. Ihara, Y. Sasaki, Y. Suzuki, S. Nishima, K. Izuhara, N. Hamasaki, and T. Hara. 2000. Childhood atopic asthma: positive association with a polymorphism of IL-4 receptor alpha gene but not with that of IL-4 promoter or Fc epsilon receptor I beta gene. Experimental and Clinical Immunogenetics 17(2): 63–70.CrossRefPubMed

11.

Lee, S.G., B.S. Kim, J.H. Kim, S.Y. Lee, S.O. Choi, J.Y. Shim, T.J. Hong, and S.J. Hong. 2004. Gene-gene interaction between interleukin-4 and interleukin-4 receptor alpha in Korean children with asthma. Clinical and Experimental Allergy 34(8): 1202–1208.CrossRefPubMed

12.

Liu, L.N., and Y.W. Zhang. 2005. Study on relationship between asthma and polymorphisms of Interleukin-4 receptor and Interleukin-4. Journal of Medicine Forum 26: 38–40.

13.

Schubert, K., H. von Bonnsdorf, M. Burke, I. Ahlert, S. Braun, R. Berner, K.A. Deichmann, and A. Heinzmann. 2006. A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis. Disease Markers 22(3): 127–132.CrossRefPubMedCentralPubMed

14.

Kabesch, M., M. Schedel, D. Carr, B. Woitsch, C. Fritzsch, S.K. Weiland, and E. von Mutius. 2006. IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. The Journal of Allergy and Clinical Immunology 117(2): 269–274.CrossRefPubMed

15.

Attab, K.A., K.M. Al-Qaoud, K. Al-Bataieneh, and M.J. Ajlouni. 2008. Association of SNP in the IL-4, IL-18 and eotaxin genes with asthma in a Jordanian population. International Journal of Integrative Biology 4: 86–91.

16.

de Faria, I.C., E.J. de Faria, A.A. Toro, J.D. Ribeiro, and C.S. Bertuzzo. 2008. Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents. Jornal de Pediatria 84(3): 203–210.PubMed

17.

Wu, X., Y. Li, Q. Chen, F. Chen, P. Cai, L. Wang, and L. Hu. 2010. Association and gene-gene interactions of eight common single-nucleotide polymorphisms with pediatric asthma in middle China. Journal of Asthma 47(3): 238–244.CrossRefPubMed

18.

Zhang, L.Y., S.G. Leng, Y.W. Zhang, S.R. Niu, and B.Y. Lu. 2010. Association between genetic polymorphism in interleukin-4 and the risk of childhood asthma. Journal of Toxicology 24: 175–179.

19.

Huang, H.R., Y.Q. Zhong, and J.F. Wu. 2011. The association between IFN-γ and IL-4 genetic polymorphisms and childhood susceptibility to bronchial asthma. Gene 494: 96–101.CrossRefPubMed

20.

Baye, T.M., M. Butsch Kovacic, J.M. Biagini Myers, L.J. Martin, M. Lindsey, T.L. Patterson, H. He, M.B. Ericksen, J. Gupta, A.M. Tsoras, A. Lindsley, M.E. Rothenberg, M. Wills-Karp, N.T. Eissa, L. Borish, and G.K. Khurana Hershey. 2011. Differences in candidate gene association between European ancestry and African American asthmatic children. PLoS One 6(2): e16522.CrossRefPubMedCentralPubMed

21.

Hwang, B.F., I. Liu, and T.P. Huang. 2012. Gene-environment interaction between Interleukin-4 promoter and molds in childhood asthma. Annals of Epidemiology 22: 250–256.CrossRefPubMed

22.

Ramphul, K., J. Lv, L. Hua, Q.H. Liu, D.Z. Fang, R.X. Ji, and Y.X. Bao. 2014. Single nucleotide polymorphisms predisposing to asthma in children of Mauritian Indian and Chinese Han ethnicity. Brazilian Journal of Medical and Biological Research 47(5): 394–397.CrossRefPubMedCentralPubMed

23.

Li, J., L.H. Lin, J. Wang, X. Peng, H.R. Dai, H. Xiao, F. Li, Y.P. Wang, Z.J. Yang, and L. Li. 2014. Interleukin-4 and interleukin-13 pathway genetics affect disease susceptibility, serum immunoglobulin E levels, and gene expression in asthma. Annals of Allergy, Asthma & Immunology 113(2): 173–179.e1.CrossRef

24.

Lama, M., M. Chatterjee, C. Nayak, and T.K. Chaudhuri. 2011. Increased interleukin-4 and decreased interferon-γ levels in serum of children with asthma. Cytokine 55: 335–338.CrossRefPubMed

25.

Shahid, S.K., S.A. Kharitonov, N.M. Wilson, A. Bush, and P.J. Barnes. 2002. Increased interleukin-4 and decreased interferon-γ in exhaled breath condensate of children with asthma. American Journal of Respiratory and Critical Care Medicine 165: 1290–1293.CrossRefPubMed

26.

Maes, T., G.F. Joos, and G.G. Brusselle. 2012. Targeting interleukin-4 in asthma: lost in translation? American Journal of Respiratory Cell and Molecular Biology 47(3): 261–270.CrossRefPubMed

Title: Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis
Authors: Suqin Zhang
Yuqin Li
Yufeng Liu
Publication date: 01-06-2015
Publisher: Springer US
Published in: Inflammation / Issue 3/2015
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-014-0086-9

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Interleukin-4 -589C/T Polymorphism is Associated with Increased Pediatric Asthma Risk: A Meta-Analysis

Abstract

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 3/2015

Inhibitory Effects of JEUD-38, a New Sesquiterpene Lactone from Inula japonica Thunb, on LPS-Induced iNOS Expression in RAW264.7 Cells

Preventive Effects of Protocatechuic Acid on LPS-Induced Inflammatory Response in Human Gingival Fibroblasts via Activating PPAR-γ

Increased Expression of T Cell Immunoglobulin and Mucin Domain 4 Is Positively Associated with the Disease Severity of Patients with Ankylosing Spondylitis

Erratum to: Potential Effects of Calcium Binding Protein S100A12 on Severity Evaluation and Curative Effect of Severe Acute Pancreatitis

Natural Killer Cell Functional Activity After 4-1BB Costimulation

I n Vitro Anti-inflammatory and Immunomodulatory Effects of Ciprofloxacin or Azithromycin in Staphylococcus aureus-Stimulated Murine Macrophages are Beneficial in the Presence of Cytochalasin D

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page