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01-10-2013

Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats

Authors: Ana Fernandez-Bustamante, Jelena Klawitter, Paul Wilson, Nancy D. Elkins, Amanda Agazio, Takahiro Shibata, Koji Uchida, Uwe Christians, John E. Repine

Published in: Inflammation | Issue 5/2013

ABSTRACT

Early detection and prevention is an important goal in acute respiratory distress syndrome research. We determined the concentration of the anti-inflammatory 15-deoxy-Δ^12,14-prostaglandin-J2 (15d-PGJ2) and other components of the cyclopentenone prostaglandin cascade in relation to lung inflammation in cytokine (IL-1/LPS)-insufflated rats. We found that 15d-PGJ2 levels increase in the bronchoalveolar lavage (BAL) fluid of rats insufflated with cytokines 2 h before. BAL 15d-PGJ2 increases preceded neutrophil recruitment, lung injury, and oxidative stress in the lungs of cytokine-insufflated rats. 15d-PGJ2 was localized in alveolar macrophages that decreased following cytokine insufflation. 15d-PGJ2 may constitute an early biomarker of lung inflammation and may reflect an endogenous attempt to regulate ongoing inflammation in macrophages and elsewhere after cytokine insufflation.

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Title: Early Increase in Alveolar Macrophage Prostaglandin 15d-PGJ2 Precedes Neutrophil Recruitment into Lungs of Cytokine-Insufflated Rats
Authors: Ana Fernandez-Bustamante
Jelena Klawitter
Paul Wilson
Nancy D. Elkins
Amanda Agazio
Takahiro Shibata
Koji Uchida
Uwe Christians
John E. Repine
Publication date: 01-10-2013
Publisher: Springer US
Published in: Inflammation / Issue 5/2013
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI: https://doi.org/10.1007/s10753-013-9635-x

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ABSTRACT

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