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Inflammation
Published in: Inflammation 1/2013

01-02-2013

Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index

Authors: Sílvia Juliane Piva, Etiane Tatsch, José Antonio Mainardi De Carvalho, Guilherme Vargas Bochi, Helena Kober, Thiago Duarte, Marta Maria Medeiros Frescura Duarte, Ivana Beatrice Mânica da Cruz, Maria Beatriz Moretto, Rafael Noal Moresco

Published in: Inflammation | Issue 1/2013

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Abstract

The aim of this study was to evaluate the inflammatory and oxidative biomarkers’ levels in obese subjects and their associations with body mass index (BMI), in order to investigate the role of these biomarkers in obesity. Fasting glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein A, apolipoprotein B, albumin, urinary albumin, creatinine, glomerular filtration rate, interleukin-6 (IL-6), nitrate/nitrite (NOx), and ischemia-modified albumin (IMA) were measured in 93 subjects divided according to different BMI. IL-6, urinary albumin, and IMA levels were significantly higher in obese subjects. However, the levels of NOx were significantly lower in this population. Significant correlations between BMI and IL-6 (r = 0.326, P = 0.002), NOx (r = −0.249, P = 0.021), urinary albumin (r = 0.270, P = 0.008), and IMA (r = 0.286, P = 0.005) were reported. We have shown an increase of IL-6, urinary albumin, and IMA combined with lower levels of NOx in obese patients and an association between of these biomarkers with BMI, suggesting a possible interplay of oxidative stress, inflammation, and endothelial dysfunction state in obesity.
Literature
1.
Flegal, K.M., M.D. Carroll, C.L. Ogden, and L.R. Curtin. 2010. Prevalence and trends in obesity among US adults, 1999–2008. Journal of the American Medical Association 303: 235–241.PubMedCrossRef
2.
3.
Shoelson, S.E., J. Lee, and A.B. Goldfine. 2006. Inflammation and insulin resistance. The Journal of Clinical Investigation 116: 1793–1801.PubMedCrossRef
4.
Tilg, H., and A.R. Moschen. 2006. Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nature Reviews Immunology 6: 772–783.PubMedCrossRef
5.
Grundy, S.M., H.B. Brewer, J.I. Cleeman, S.C. Smith, and C. Lenfant. 2004. Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109: 433–438.PubMedCrossRef
6.
Vassalle, C., L. Pratali, C. Boni, A. Mercuri, and R. Ndreu. 2008. An oxidative stress score as a combined measure of the pro-oxidant and anti-oxidant counterparts in patients with coronary artery disease. Clinical Biochemistry 41: 1162–1167.PubMedCrossRef
7.
Li, Q., and I.M. Verma. 2002. NF-kappaB regulation in the immune system. Nature Reviews Immunology 2: 725–734.PubMedCrossRef
8.
Lowe, G.D.O., A. Rumley, A.D. McMahon, I. Ford, D.S. O’Reilly, and C.J. Packard. 2004. Interleukin-6, fibrin D-dimer, and coagulation factors VII and XIIa in prediction of coronary heart disease. Arteriosclerosis, Thrombosis, and Vascular Biology 24: 1529–1534.PubMedCrossRef
9.
Roytblat, L., M. Rachinsky, A. Fisher, L. Greemberg, Y. Shapira, A. Douvdevani, and S. Gelman. 2000. Raised interleukin-6 levels in obese patients. Obesity Research 8: 673–675.PubMedCrossRef
10.
Futrakul, N., V. Sridama, and P. Futrakul. 2009. Microalbuminuria—A biomarker of renal microvascular disease. Renal Failure 31: 140–143.PubMedCrossRef
11.
Hillege, H.L., V. Fidler, G.F. Diercks, W.H. van Gilst, D. de Zeeuw, D.J. van Veldhuisen, R.O. Gans, W.M. Janssen, D.E. Grobbee, and P.E. de Jong. 2002. Urinary albumin excretion predicts cardiovascular and noncardiovascular mortality in general population. Circulation 106: 1777–1782.PubMedCrossRef
12.
Zou, M.H., R. Cohen, and V. Ullrich. 2004. Peroxynitrite and vascular endothelial dysfunction in diabetes mellitus. Endothelium 11: 89–97.PubMedCrossRef
13.
Sánchez, A.F., E.M. Santillán, M. Bautista, J.E. Soto, A.M. González, C.E. Chirino, I.D. Montiel, G.S. Rivera, C.V. Veja, and J.A.M. González. 2011. Inflammation, oxidative stress, and obesity. International Journal of Molecular Sciences 12: 3117–3132.CrossRef
14.
Higashi, Y., S. Sasaki, K. Nakagawa, H. Matsuura, K. Chayama, and T. Oshima. 2001. Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension. American Journal of Hypertension 14: 1038–1045.PubMedCrossRef
15.
Bourdon, E., N. Loreau, and D. Blache. 1999. Glucose and free radicals impair the antioxidant properties of serum albumin. FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology 13: 233–244.
16.
Piva, S.J., M.M.F. Duarte, I.B. da Cruz, A.C. Coelho, A.P. Moreira, R. Tonello, S.C. Garcia, and R.N. Moresco. 2011. Ischemia-modified albumin as an oxidative stress biomarker in obesity. Clinical Biochemistry 44: 345–347.PubMedCrossRef
17.
Newman, D.J., M.J. Pugia, J.A. Lott, J.F. Wallace, and A. Hiar. 2000. Urinary protein and albumin excretion corrected by creatinine and specific gravity. Clinica Chimica Acta 294: 139–155.CrossRef
18.
Kaefer, M., S.J. Piva, J.A. de Carvalho, D.B. da Silva, A.M. Becker, A.C. Coelho, M.M. Duarte, and R.N. Moresco. 2010. Association between ischemia modified albumin, inflammation and hyperglycemia in type 2 diabetes mellitus. Clinical Biochemistry 43: 450–454.PubMedCrossRef
19.
Tatsch, E., G.V. Bochi, R.S. Pereira, H. Kober, V.A. Agertt, M.M.A. Campos, P. Gomes, M.M. Duarte, and R.N. Moresco. 2011. A simple and inexpensive automated technique for measurement of serum nitrite/nitrate. Clinical Biochemistry 44: 348–350.PubMedCrossRef
20.
Friedewald, W.T., R.I. Levy, and D.S. Fredrickson. 1972. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18: 499–502.PubMed
21.
Levey, A.S., J.P. Bosch, J.B. Lewis, T. Greene, N. Rogers, and D. Roth. 1999. A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group. Annals of Internal Medicine 130: 461–470.PubMed
22.
Park, H.S., J.Y. Park, and R. Yu. 2005. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-α and IL-6. Diabetes Research and Clinical Practice 29: 29–35.CrossRef
23.
Malnick, S.D.H., and H. Knobler. 2006. The medical complications of obesity. QJM: Monthly Journal of the Association of Physicians 99: 565–579.PubMedCrossRef
24.
Kopp, H.P., C.W. Kopp, A. Festa, K. Krzyzanowska, S. Kriwanek, E. Roka, and G. Schernthaner. 2003. Impact of weight loss on inflammatory proteins and their association with the insulin resistance syndrome in morbidly obese patients. Arteriosclerosis, Thrombosis, and Vascular Biology 23: 1042–1047.PubMedCrossRef
25.
Vincent, H.K., and A.G. Taylor. 2006. Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans. International Journal of Obesity 30: 400–418.PubMedCrossRef
26.
Elmarakby, A.A., and J.C. Sullivan. 2012. Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy. Cardiovascular Therapeutics 30: 49–59.PubMedCrossRef
27.
Ouchi, N., J.L. Parker, J.J. Lugus, and K. Walsh. 2011. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology 11: 85–97.PubMedCrossRef
28.
Pickup, J.C., M.B. Mattock, G.D. Chusney, and D. Burt. 1997. NIDDM as a disease of the innate immune system: Association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40: 1286–1292.PubMedCrossRef
29.
Poirier, P., T.D. Giles, G.A. Bray, Y. Hong, J.S. Stern, F.X. Pi-Sunyer, and R.H. Eckel. 2006. Obesity and cardiovascular disease: Pathophysiology, evaluation, and effect of weight loss: An update of the 1997 American Heart Association scientific statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation 113: 898–918.PubMedCrossRef
30.
Tseng, C.H. 2009. Differential dyslipidemia associated with albuminuria in type 2 diabetic patients in Taiwan. Clinical Biochemistry 42: 1019–1024.PubMedCrossRef
31.
Thoenes, M., R.J. Reil, B.V. Khan, P. Bramlage, M. Volpe, W. Kirch, and M. Böhm. 2009. Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension. Vascular Health and Risk Management 5: 577–585.PubMed
32.
Elahi, M.M., K.M. Naseem, and B.M. Matata. 2007. Nitric oxide in blood. The nitrosative-oxidative disequilibrium hypothesis on the pathogenesis of cardiovascular disease. Federation of European Biochemical Societies Journal 274: 906–923.PubMed
33.
Duarte, M.M.M.F., J.B.T. Rocha, R.N. Moresco, T. Duarte, I.B. da Cruz, V.L. Loro, and M.R. Schetinger. 2009. Association between ischemia modified albumin, lipids and inflammation biomarkers in patients with hypercholesterolemia. Clinical Biochemistry 42: 666–671.PubMedCrossRef
34.
Gottlieb, M.G.V., I.B. da Cruz, M.M. Duarte, R.N. Moresco, M. Wiehe, C.H. Schwanke, and L.C. Bodanese. 2010. Associations among metabolic syndrome, ischemia, inflammatory, oxidative, and lipids biomarkers. Journal of Clinical Endocrinology and Metabolism 95: 586–591.CrossRef
35.
Bhagavan, N.V., J.S. Ha, J.H. Park, S.A. Honda, C.N. Rios, C. Sugiyama, G.K. Fujitani, I.K. Takeuchi, and C.E. Ha. 2009. Utility of serum fatty acid concentrations as a marker for acute myocardial infarction and their potential role in the formation of ischemia-modified albumin: A pilot study. Clinical Chemistry 55: 1588–1590.PubMedCrossRef
Metadata
Title
Assessment of Inflammatory and Oxidative Biomarkers in Obesity and Their Associations with Body Mass Index
Authors
Sílvia Juliane Piva
Etiane Tatsch
José Antonio Mainardi De Carvalho
Guilherme Vargas Bochi
Helena Kober
Thiago Duarte
Marta Maria Medeiros Frescura Duarte
Ivana Beatrice Mânica da Cruz
Maria Beatriz Moretto
Rafael Noal Moresco
Publication date
01-02-2013
Publisher
Springer US
Published in
Inflammation / Issue 1/2013
Print ISSN: 0360-3997
Electronic ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-012-9538-2

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