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Published in: Heart Failure Reviews 1/2017

01-01-2017

Symptom burden in heart failure: assessment, impact on outcomes, and management

Authors: Craig M. Alpert, Michael A. Smith, Scott L. Hummel, Ellen K. Hummel

Published in: Heart Failure Reviews | Issue 1/2017

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Abstract

Evidence-based management has improved long-term survival in patients with heart failure (HF). However, an unintended consequence of increased longevity is that patients with HF are exposed to a greater symptom burden over time. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suffer additional symptoms such as pain, depression, gastrointestinal distress, and fatigue. In addition to obvious effects on quality of life, untreated symptoms increase clinical events including emergency department visits, hospitalizations, and long-term mortality in a dose-dependent fashion. Symptom management in patients with HF consists of two key components: comprehensive symptom assessment and sufficient knowledge of available approaches to alleviate the symptoms. Successful treatment addresses not just the physical but also the emotional, social, and spiritual aspects of suffering. Despite a lack of formal experience during cardiovascular training, symptom management in HF can be learned and implemented effectively by cardiology providers. Co-management with palliative medicine specialists can add significant value across the spectrum and throughout the course of HF.
Literature
1.
go back to reference Heidenreich PA, Albert NM, Allen LA et al (2013) Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail 6(3):606–619PubMedPubMedCentralCrossRef Heidenreich PA, Albert NM, Allen LA et al (2013) Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ Heart Fail 6(3):606–619PubMedPubMedCentralCrossRef
2.
go back to reference Yancy CW, Jessup M, Bozkurt B et al (2013) ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. J Am Coll Cardiol 62(16):e147–e239PubMedCrossRef Yancy CW, Jessup M, Bozkurt B et al (2013) ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association task force on practice guidelines. J Am Coll Cardiol 62(16):e147–e239PubMedCrossRef
3.
go back to reference Singer PA, Martin DK, Kelner M (1999) Quality end-of-life care: patients’ perspectives. JAMA 281:163–168PubMedCrossRef Singer PA, Martin DK, Kelner M (1999) Quality end-of-life care: patients’ perspectives. JAMA 281:163–168PubMedCrossRef
4.
go back to reference Stanek EJ, Oates MB, McGhan WF, Denofrio D, Loh E (2000) Preferences for treatment outcomes in patients with heart failure: symptoms versus survival. J Card Fail 6:225–232PubMedCrossRef Stanek EJ, Oates MB, McGhan WF, Denofrio D, Loh E (2000) Preferences for treatment outcomes in patients with heart failure: symptoms versus survival. J Card Fail 6:225–232PubMedCrossRef
5.
go back to reference Stevenson LW, Hellkamp AS, Leier CV et al (2008) Changing preferences for survival after hospitalization with advanced heart failure. J Am Coll Cardiol 52:1702–1708PubMedPubMedCentralCrossRef Stevenson LW, Hellkamp AS, Leier CV et al (2008) Changing preferences for survival after hospitalization with advanced heart failure. J Am Coll Cardiol 52:1702–1708PubMedPubMedCentralCrossRef
6.
go back to reference Jalowiec A, Grady KL, White-Williams C (1994) Stressors in patients awaiting a heart transplant. Behav Med 19:145–154PubMedCrossRef Jalowiec A, Grady KL, White-Williams C (1994) Stressors in patients awaiting a heart transplant. Behav Med 19:145–154PubMedCrossRef
7.
go back to reference Chochinov HM, Tataryn D, Clinch JJ, Dudgeon D (1999) Will to live in the terminally ill. Lancet 354:816–819PubMedCrossRef Chochinov HM, Tataryn D, Clinch JJ, Dudgeon D (1999) Will to live in the terminally ill. Lancet 354:816–819PubMedCrossRef
8.
go back to reference Steinhauser KE, Clipp EC, McNeilly M, Christakis NA, McIntyre LM, Tulsky JA (2000) In search of a good death: observations of patients, families, and providers. Ann Intern Med 132:825–832PubMedCrossRef Steinhauser KE, Clipp EC, McNeilly M, Christakis NA, McIntyre LM, Tulsky JA (2000) In search of a good death: observations of patients, families, and providers. Ann Intern Med 132:825–832PubMedCrossRef
9.
go back to reference Singer AE, Meeker D, Teno JM, Lynn J, Lunney JR, Lorenz KA (2015) Symptom trends in the last year of life from 1998 to 2010: a cohort study. Ann Intern Med 162:175–183PubMedPubMedCentralCrossRef Singer AE, Meeker D, Teno JM, Lynn J, Lunney JR, Lorenz KA (2015) Symptom trends in the last year of life from 1998 to 2010: a cohort study. Ann Intern Med 162:175–183PubMedPubMedCentralCrossRef
10.
go back to reference Qaseem A, Snow V, Shekelle P et al (2008) Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med 148:141–146PubMedCrossRef Qaseem A, Snow V, Shekelle P et al (2008) Evidence-based interventions to improve the palliative care of pain, dyspnea, and depression at the end of life: a clinical practice guideline from the American College of Physicians. Ann Intern Med 148:141–146PubMedCrossRef
11.
go back to reference Brannstrom M, Hagglund L, Furst CJ, Boman K (2012) Unequal care for dying patients in Sweden: a comparative registry study of deaths from heart disease and cancer. Eur J Cardiovasc Nurs 11:454–459PubMed Brannstrom M, Hagglund L, Furst CJ, Boman K (2012) Unequal care for dying patients in Sweden: a comparative registry study of deaths from heart disease and cancer. Eur J Cardiovasc Nurs 11:454–459PubMed
12.
go back to reference Brannstrom M, Boman K (2014) Effects of person-centred and integrated chronic heart failure and palliative home care. PREFER: a randomized controlled study. Eur J Heart Fail 16:1142–1151PubMedCrossRef Brannstrom M, Boman K (2014) Effects of person-centred and integrated chronic heart failure and palliative home care. PREFER: a randomized controlled study. Eur J Heart Fail 16:1142–1151PubMedCrossRef
13.
go back to reference Setoguchi S, Glynn RJ, Stedman M, Flavell CM, Levin R, Stevenson LW (2010) Hospice, opiates, and acute care service use among the elderly before death from heart failure or cancer. Am Heart J 160:139–144PubMedPubMedCentralCrossRef Setoguchi S, Glynn RJ, Stedman M, Flavell CM, Levin R, Stevenson LW (2010) Hospice, opiates, and acute care service use among the elderly before death from heart failure or cancer. Am Heart J 160:139–144PubMedPubMedCentralCrossRef
14.
go back to reference Wilson IB, Cleary PD (1995) Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA 273:59–65PubMedCrossRef Wilson IB, Cleary PD (1995) Linking clinical variables with health-related quality of life. A conceptual model of patient outcomes. JAMA 273:59–65PubMedCrossRef
15.
go back to reference Hinton JM (1963) The physical and mental distress of the dying. Q J Med 32:1–21PubMed Hinton JM (1963) The physical and mental distress of the dying. Q J Med 32:1–21PubMed
16.
go back to reference Evangelista LS, Lombardo D, Malik S, Ballard-Hernandez J, Motie M, Liao S (2012) Examining the effects of an outpatient palliative care consultation on symptom burden, depression, and quality of life in patients with symptomatic heart failure. J Card Fail 18:894–899PubMedPubMedCentralCrossRef Evangelista LS, Lombardo D, Malik S, Ballard-Hernandez J, Motie M, Liao S (2012) Examining the effects of an outpatient palliative care consultation on symptom burden, depression, and quality of life in patients with symptomatic heart failure. J Card Fail 18:894–899PubMedPubMedCentralCrossRef
17.
go back to reference Solano JP, Gomes B, Higginson IJ (2006) A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manag 31:58–69CrossRef Solano JP, Gomes B, Higginson IJ (2006) A comparison of symptom prevalence in far advanced cancer, AIDS, heart disease, chronic obstructive pulmonary disease and renal disease. J Pain Symptom Manag 31:58–69CrossRef
18.
go back to reference Bekelman DB, Rumsfeld JS, Havranek EP et al (2009) Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients. J Gen Intern Med 24:592–598PubMedPubMedCentralCrossRef Bekelman DB, Rumsfeld JS, Havranek EP et al (2009) Symptom burden, depression, and spiritual well-being: a comparison of heart failure and advanced cancer patients. J Gen Intern Med 24:592–598PubMedPubMedCentralCrossRef
19.
go back to reference Nordgren L, Sorensen S (2003) Symptoms experienced in the last six months of life in patients with end-stage heart failure. Eur J Cardiovasc Nurs 2:213–217PubMedCrossRef Nordgren L, Sorensen S (2003) Symptoms experienced in the last six months of life in patients with end-stage heart failure. Eur J Cardiovasc Nurs 2:213–217PubMedCrossRef
20.
go back to reference Lokker ME, Gwyther L, Riley JP, van Zuylen L, van der Heide A, Harding R (2016) The prevalence and associated distress of physical and psychological symptoms in patients with advanced heart failure attending a South African Medical Center. J Cardiovasc Nurs 31(4):313–322PubMedCrossRef Lokker ME, Gwyther L, Riley JP, van Zuylen L, van der Heide A, Harding R (2016) The prevalence and associated distress of physical and psychological symptoms in patients with advanced heart failure attending a South African Medical Center. J Cardiovasc Nurs 31(4):313–322PubMedCrossRef
21.
go back to reference Bekelman DB, Havranek EP, Becker DM et al (2007) Symptoms, depression, and quality of life in patients with heart failure. J Card Fail 13:643–648PubMedCrossRef Bekelman DB, Havranek EP, Becker DM et al (2007) Symptoms, depression, and quality of life in patients with heart failure. J Card Fail 13:643–648PubMedCrossRef
22.
go back to reference Zambroski CH, Moser DK, Bhat G, Ziegler C (2005) Impact of symptom prevalence and symptom burden on quality of life in patients with heart failure. Eur J Cardiovasc Nurs 4:198–206PubMedCrossRef Zambroski CH, Moser DK, Bhat G, Ziegler C (2005) Impact of symptom prevalence and symptom burden on quality of life in patients with heart failure. Eur J Cardiovasc Nurs 4:198–206PubMedCrossRef
23.
go back to reference Lewis EF, Lamas GA, O’Meara E et al (2007) Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM. Eur J Heart Fail 9:83–91PubMedCrossRef Lewis EF, Lamas GA, O’Meara E et al (2007) Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM. Eur J Heart Fail 9:83–91PubMedCrossRef
24.
go back to reference Kugler C, Malehsa D, Tegtbur U et al (2011) Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study. J Heart Lung Transplant 30:204–210PubMedCrossRef Kugler C, Malehsa D, Tegtbur U et al (2011) Health-related quality of life and exercise tolerance in recipients of heart transplants and left ventricular assist devices: a prospective, comparative study. J Heart Lung Transplant 30:204–210PubMedCrossRef
25.
go back to reference Simon JR (2008) Case study. “Doctor, will you turn off my LVAD?” Commentary. Hastings Cent Rep 38:14–15PubMedCrossRef Simon JR (2008) Case study. “Doctor, will you turn off my LVAD?” Commentary. Hastings Cent Rep 38:14–15PubMedCrossRef
26.
go back to reference Casida JM, Parker J (2012) A preliminary investigation of symptom pattern and prevalence before and up to 6 months after implantation of a left ventricular assist device. J Artif Organs 15:211–214PubMedCrossRef Casida JM, Parker J (2012) A preliminary investigation of symptom pattern and prevalence before and up to 6 months after implantation of a left ventricular assist device. J Artif Organs 15:211–214PubMedCrossRef
27.
go back to reference Grady KL, Meyer PM, Dressler D et al (2004) Longitudinal change in quality of life and impact on survival after left ventricular assist device implantation. Ann Thorac Surg 77:1321–1327PubMedCrossRef Grady KL, Meyer PM, Dressler D et al (2004) Longitudinal change in quality of life and impact on survival after left ventricular assist device implantation. Ann Thorac Surg 77:1321–1327PubMedCrossRef
28.
go back to reference Jalowiec A, Grady KL, White-Williams C et al (1997) Symptom distress three months after heart transplantation. J Heart Lung Transplant 16:604–614PubMed Jalowiec A, Grady KL, White-Williams C et al (1997) Symptom distress three months after heart transplantation. J Heart Lung Transplant 16:604–614PubMed
29.
go back to reference Rosenblum DS, Rosen ML, Pine ZM, Rosen SH, Borg-Stein J (1993) Health status and quality of life following cardiac transplantation. Arch Phys Med Rehabil 74:490–493PubMedCrossRef Rosenblum DS, Rosen ML, Pine ZM, Rosen SH, Borg-Stein J (1993) Health status and quality of life following cardiac transplantation. Arch Phys Med Rehabil 74:490–493PubMedCrossRef
30.
go back to reference Gadoud A, Jenkins SM, Hogg KJ (2013) Palliative care for people with heart failure: summary of current evidence and future direction. Palliat Med 27:822–828PubMedCrossRef Gadoud A, Jenkins SM, Hogg KJ (2013) Palliative care for people with heart failure: summary of current evidence and future direction. Palliat Med 27:822–828PubMedCrossRef
31.
32.
go back to reference Jaarsma T, Beattie JM, Ryder M et al (2009) Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 11:433–443PubMedCrossRef Jaarsma T, Beattie JM, Ryder M et al (2009) Palliative care in heart failure: a position statement from the palliative care workshop of the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 11:433–443PubMedCrossRef
33.
go back to reference Walke LM, Byers AL, Tinetti ME, Dubin JA, McCorkle R, Fried TR (2007) Range and severity of symptoms over time among older adults with chronic obstructive pulmonary disease and heart failure. Arch Intern Med 167:2503–2508PubMedPubMedCentralCrossRef Walke LM, Byers AL, Tinetti ME, Dubin JA, McCorkle R, Fried TR (2007) Range and severity of symptoms over time among older adults with chronic obstructive pulmonary disease and heart failure. Arch Intern Med 167:2503–2508PubMedPubMedCentralCrossRef
34.
go back to reference Barnes S, Gott M, Payne S et al (2006) Prevalence of symptoms in a community-based sample of heart failure patients. J Pain Symptom Manag 32:208–216CrossRef Barnes S, Gott M, Payne S et al (2006) Prevalence of symptoms in a community-based sample of heart failure patients. J Pain Symptom Manag 32:208–216CrossRef
35.
go back to reference Levenson JW, McCarthy EP, Lynn J, Davis RB, Phillips RS (2000) The last six months of life for patients with congestive heart failure. J Am Geriatr Soc 48:S101–S109PubMedCrossRef Levenson JW, McCarthy EP, Lynn J, Davis RB, Phillips RS (2000) The last six months of life for patients with congestive heart failure. J Am Geriatr Soc 48:S101–S109PubMedCrossRef
36.
go back to reference Kirkpatrick JN, Guger CJ, Arnsdorf MF, Fedson SE (2007) Advance directives in the cardiac care unit. Am Heart J 154:477–481PubMedCrossRef Kirkpatrick JN, Guger CJ, Arnsdorf MF, Fedson SE (2007) Advance directives in the cardiac care unit. Am Heart J 154:477–481PubMedCrossRef
37.
go back to reference Chen-Scarabelli C, Saravolatz L, Hirsh B, Agrawal P, Scarabelli TM (2015) Dilemmas in end-stage heart failure. J Geriatr Cardiol 12:57–65PubMedPubMedCentral Chen-Scarabelli C, Saravolatz L, Hirsh B, Agrawal P, Scarabelli TM (2015) Dilemmas in end-stage heart failure. J Geriatr Cardiol 12:57–65PubMedPubMedCentral
39.
go back to reference Malik FA, Gysels M, Higginson IJ (2013) Living with breathlessness: a survey of caregivers of breathless patients with lung cancer or heart failure. Palliat Med 27:647–656PubMedCrossRef Malik FA, Gysels M, Higginson IJ (2013) Living with breathlessness: a survey of caregivers of breathless patients with lung cancer or heart failure. Palliat Med 27:647–656PubMedCrossRef
40.
go back to reference Whittingham K, Barnes S, Gardiner C (2013) Tools to measure quality of life and carer burden in informal carers of heart failure patients: a narrative review. Palliat Med 27:596–607PubMedCrossRef Whittingham K, Barnes S, Gardiner C (2013) Tools to measure quality of life and carer burden in informal carers of heart failure patients: a narrative review. Palliat Med 27:596–607PubMedCrossRef
41.
go back to reference Lee CS, Gelow JM, Denfeld QE et al (2014) Physical and psychological symptom profiling and event-free survival in adults with moderate to advanced heart failure. J Cardiovasc Nurs 29:315–323PubMedPubMedCentralCrossRef Lee CS, Gelow JM, Denfeld QE et al (2014) Physical and psychological symptom profiling and event-free survival in adults with moderate to advanced heart failure. J Cardiovasc Nurs 29:315–323PubMedPubMedCentralCrossRef
42.
go back to reference Ekman I, Cleland JG, Swedberg K, Charlesworth A, Metra M, Poole-Wilson PA (2005) Symptoms in patients with heart failure are prognostic predictors: insights from COMET. J Card Fail 11:288–292PubMedCrossRef Ekman I, Cleland JG, Swedberg K, Charlesworth A, Metra M, Poole-Wilson PA (2005) Symptoms in patients with heart failure are prognostic predictors: insights from COMET. J Card Fail 11:288–292PubMedCrossRef
43.
go back to reference Patel H, Shafazand M, Schaufelberger M, Ekman I (2007) Reasons for seeking acute care in chronic heart failure. Eur J Heart Fail 9:702–708PubMedCrossRef Patel H, Shafazand M, Schaufelberger M, Ekman I (2007) Reasons for seeking acute care in chronic heart failure. Eur J Heart Fail 9:702–708PubMedCrossRef
45.
go back to reference Goebel JR, Doering LV, Shugarman LR et al (2009) Heart failure: the hidden problem of pain. J Pain Symptom Manag 38:698–707CrossRef Goebel JR, Doering LV, Shugarman LR et al (2009) Heart failure: the hidden problem of pain. J Pain Symptom Manag 38:698–707CrossRef
46.
go back to reference Goode KM, Nabb S, Cleland JG, Clark AL (2008) A comparison of patient and physician-rated New York Heart Association class in a community-based heart failure clinic. J Card Fail 14:379–387PubMedCrossRef Goode KM, Nabb S, Cleland JG, Clark AL (2008) A comparison of patient and physician-rated New York Heart Association class in a community-based heart failure clinic. J Card Fail 14:379–387PubMedCrossRef
47.
go back to reference Ekman I, Cleland JG, Andersson B, Swedberg K (2005) Exploring symptoms in chronic heart failure. Eur J Heart Fail 7:699–703PubMedCrossRef Ekman I, Cleland JG, Andersson B, Swedberg K (2005) Exploring symptoms in chronic heart failure. Eur J Heart Fail 7:699–703PubMedCrossRef
48.
go back to reference Thomas JM, O’Leary JR, Fried TR (2009) Understanding their options: determinants of hospice discussion for older persons with advanced illness. J Gen Intern Med 24:923–928PubMedPubMedCentralCrossRef Thomas JM, O’Leary JR, Fried TR (2009) Understanding their options: determinants of hospice discussion for older persons with advanced illness. J Gen Intern Med 24:923–928PubMedPubMedCentralCrossRef
49.
go back to reference Lynn J, Harrell F Jr, Cohn F, Wagner D, Connors AF Jr (1997) Prognoses of seriously ill hospitalized patients on the days before death: implications for patient care and public policy. New Horiz 5:56–61PubMed Lynn J, Harrell F Jr, Cohn F, Wagner D, Connors AF Jr (1997) Prognoses of seriously ill hospitalized patients on the days before death: implications for patient care and public policy. New Horiz 5:56–61PubMed
50.
go back to reference Low J, Pattenden J, Candy B, Beattie JM, Jones L (2011) Palliative care in advanced heart failure: an international review of the perspectives of recipients and health professionals on care provision. J Card Fail 17:231–252PubMedCrossRef Low J, Pattenden J, Candy B, Beattie JM, Jones L (2011) Palliative care in advanced heart failure: an international review of the perspectives of recipients and health professionals on care provision. J Card Fail 17:231–252PubMedCrossRef
51.
go back to reference Friedman MM (1997) Older adults’ symptoms and their duration before hospitalization for heart failure. Heart Lung 26:169–176PubMedCrossRef Friedman MM (1997) Older adults’ symptoms and their duration before hospitalization for heart failure. Heart Lung 26:169–176PubMedCrossRef
52.
go back to reference Jurgens CY, Shurpin KM, Gumersell KA (2010) Challenges and strategies for heart failure symptom management in older adults. J Gerontol Nurs 36:24–33PubMed Jurgens CY, Shurpin KM, Gumersell KA (2010) Challenges and strategies for heart failure symptom management in older adults. J Gerontol Nurs 36:24–33PubMed
53.
go back to reference Rogers A, Addington-Hall JM, McCoy AS et al (2002) A qualitative study of chronic heart failure patients’ understanding of their symptoms and drug therapy. Eur J Heart Fail 4:283–287PubMedCrossRef Rogers A, Addington-Hall JM, McCoy AS et al (2002) A qualitative study of chronic heart failure patients’ understanding of their symptoms and drug therapy. Eur J Heart Fail 4:283–287PubMedCrossRef
54.
go back to reference Bennett SJ, Cordes DK, Westmoreland G, Castro R, Donnelly E (2000) Self-care strategies for symptom management in patients with chronic heart failure. Nurs Res 49:139–145PubMedCrossRef Bennett SJ, Cordes DK, Westmoreland G, Castro R, Donnelly E (2000) Self-care strategies for symptom management in patients with chronic heart failure. Nurs Res 49:139–145PubMedCrossRef
55.
go back to reference Blinderman CD, Billings JA (2015) Comfort care for patients dying in the hospital. N Engl J Med 373:2549–2561PubMedCrossRef Blinderman CD, Billings JA (2015) Comfort care for patients dying in the hospital. N Engl J Med 373:2549–2561PubMedCrossRef
56.
go back to reference Ezekowitz JA, Thai V, Hodnefield TS, Sanderson L, Cujec B (2011) The correlation of standard heart failure assessment and palliative care questionnaires in a multidisciplinary heart failure clinic. J Pain Symptom Manag 42:379–387CrossRef Ezekowitz JA, Thai V, Hodnefield TS, Sanderson L, Cujec B (2011) The correlation of standard heart failure assessment and palliative care questionnaires in a multidisciplinary heart failure clinic. J Pain Symptom Manag 42:379–387CrossRef
57.
go back to reference Opasich C, Gualco A (2007) The complex symptom burden of the aged heart failure population. Curr Opin Support Palliat Care 1:255–259PubMedCrossRef Opasich C, Gualco A (2007) The complex symptom burden of the aged heart failure population. Curr Opin Support Palliat Care 1:255–259PubMedCrossRef
58.
go back to reference Heidenreich PA, Spertus JA, Jones PG et al (2006) Health status identifies heart failure outpatients at risk for hospitalization or death. J Am Coll Cardiol 47:752–756PubMedCrossRef Heidenreich PA, Spertus JA, Jones PG et al (2006) Health status identifies heart failure outpatients at risk for hospitalization or death. J Am Coll Cardiol 47:752–756PubMedCrossRef
59.
go back to reference Song EK, Moser DK, Rayens MK, Lennie TA (2010) Symptom clusters predict event-free survival in patients with heart failure. J Cardiovasc Nurs 25:284–291PubMedPubMedCentralCrossRef Song EK, Moser DK, Rayens MK, Lennie TA (2010) Symptom clusters predict event-free survival in patients with heart failure. J Cardiovasc Nurs 25:284–291PubMedPubMedCentralCrossRef
61.
go back to reference Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL (2008) Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manag 35:594–603CrossRef Blinderman CD, Homel P, Billings JA, Portenoy RK, Tennstedt SL (2008) Symptom distress and quality of life in patients with advanced congestive heart failure. J Pain Symptom Manag 35:594–603CrossRef
62.
go back to reference Goebel JR, Doering LV, Evangelista LS et al (2009) A comparative study of pain in heart failure and non-heart failure veterans. J Card Fail 15:24–30PubMedCrossRef Goebel JR, Doering LV, Evangelista LS et al (2009) A comparative study of pain in heart failure and non-heart failure veterans. J Card Fail 15:24–30PubMedCrossRef
63.
go back to reference Goodlin SJ, Wingate S, Albert NM et al (2012) Investigating pain in heart failure patients: the pain assessment, incidence, and nature in heart failure (PAIN-HF) study. J Card Fail 18:776–783PubMedCrossRef Goodlin SJ, Wingate S, Albert NM et al (2012) Investigating pain in heart failure patients: the pain assessment, incidence, and nature in heart failure (PAIN-HF) study. J Card Fail 18:776–783PubMedCrossRef
64.
go back to reference Ballantyne JC, Sullivan MD (2015) Intensity of chronic pain-the wrong metric? N Engl J Med 373:2098–2099PubMedCrossRef Ballantyne JC, Sullivan MD (2015) Intensity of chronic pain-the wrong metric? N Engl J Med 373:2098–2099PubMedCrossRef
65.
go back to reference Ferrell BR, Coyle N (2008) The nature of suffering and the goals of nursing. Oncol Nurs Forum 35:241–247PubMedCrossRef Ferrell BR, Coyle N (2008) The nature of suffering and the goals of nursing. Oncol Nurs Forum 35:241–247PubMedCrossRef
66.
go back to reference Udeoji DU, Shah AB, Bharadwaj P, Katsiyiannis P, Schwarz ER (2012) Evaluation of the prevalence and severity of pain in patients with stable chronic heart failure. World J Cardiol 4:250–255PubMedPubMedCentralCrossRef Udeoji DU, Shah AB, Bharadwaj P, Katsiyiannis P, Schwarz ER (2012) Evaluation of the prevalence and severity of pain in patients with stable chronic heart failure. World J Cardiol 4:250–255PubMedPubMedCentralCrossRef
67.
go back to reference Godfrey C, Harrison MB, Medves J, Tranmer JE (2006) The symptom of pain with heart failure: a systematic review. J Card Fail 12:307–313PubMedCrossRef Godfrey C, Harrison MB, Medves J, Tranmer JE (2006) The symptom of pain with heart failure: a systematic review. J Card Fail 12:307–313PubMedCrossRef
68.
go back to reference Gureje O, Von Korff M, Simon GE, Gater R (1998) Persistent pain and well-being: a World Health Organization study in primary care. JAMA 280:147–151PubMedCrossRef Gureje O, Von Korff M, Simon GE, Gater R (1998) Persistent pain and well-being: a World Health Organization study in primary care. JAMA 280:147–151PubMedCrossRef
69.
go back to reference Evangelista LS, Berg J, Dracup K (2001) Relationship between psychosocial variables and compliance in patients with heart failure. Heart Lung 30:294–301PubMedCrossRef Evangelista LS, Berg J, Dracup K (2001) Relationship between psychosocial variables and compliance in patients with heart failure. Heart Lung 30:294–301PubMedCrossRef
70.
go back to reference McCaffery M, Pasero C (1999) Pain: clinical manual, 2nd edn. Mosby, St. Louis McCaffery M, Pasero C (1999) Pain: clinical manual, 2nd edn. Mosby, St. Louis
71.
go back to reference Light-McGroary K, Goodlin SJ (2013) The challenges of understanding and managing pain in the heart failure patient. Curr Opin Support Palliat Care 7:14–20PubMedCrossRef Light-McGroary K, Goodlin SJ (2013) The challenges of understanding and managing pain in the heart failure patient. Curr Opin Support Palliat Care 7:14–20PubMedCrossRef
72.
go back to reference Adler ED, Goldfinger JZ, Kalman J, Park ME, Meier DE (2009) Palliative care in the treatment of advanced heart failure. Circulation 120:2597–2606PubMedCrossRef Adler ED, Goldfinger JZ, Kalman J, Park ME, Meier DE (2009) Palliative care in the treatment of advanced heart failure. Circulation 120:2597–2606PubMedCrossRef
74.
go back to reference Lee H, Schmidt K, Ernst E (2005) Acupuncture for the relief of cancer-related pain–a systematic review. Eur J Pain 9:437–444PubMedCrossRef Lee H, Schmidt K, Ernst E (2005) Acupuncture for the relief of cancer-related pain–a systematic review. Eur J Pain 9:437–444PubMedCrossRef
75.
go back to reference Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G (2005) Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol 23:3830–3842PubMedCrossRef Knols R, Aaronson NK, Uebelhart D, Fransen J, Aufdemkampe G (2005) Physical exercise in cancer patients during and after medical treatment: a systematic review of randomized and controlled clinical trials. J Clin Oncol 23:3830–3842PubMedCrossRef
76.
go back to reference Cepeda MS, Carr DB, Lau J, Alvarez H (2006) Music for pain relief. Cochrane Database Syst Rev 2:CD004843 Cepeda MS, Carr DB, Lau J, Alvarez H (2006) Music for pain relief. Cochrane Database Syst Rev 2:CD004843
77.
go back to reference Feenstra J, Heerdink ER, Grobbee DE, Stricker BH (2002) Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure: the Rotterdam Study. Arch Intern Med 162:265–270PubMedCrossRef Feenstra J, Heerdink ER, Grobbee DE, Stricker BH (2002) Association of nonsteroidal anti-inflammatory drugs with first occurrence of heart failure and with relapsing heart failure: the Rotterdam Study. Arch Intern Med 162:265–270PubMedCrossRef
78.
go back to reference Page J, Henry D (2000) Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem. Arch Intern Med 160:777–784PubMedCrossRef Page J, Henry D (2000) Consumption of NSAIDs and the development of congestive heart failure in elderly patients: an underrecognized public health problem. Arch Intern Med 160:777–784PubMedCrossRef
80.
go back to reference Gimbel J, Linn R, Hale M, Nicholson B (2005) Lidocaine patch treatment in patients with low back pain: results of an open-label, nonrandomized pilot study. Am J Ther 12:311–319PubMedCrossRef Gimbel J, Linn R, Hale M, Nicholson B (2005) Lidocaine patch treatment in patients with low back pain: results of an open-label, nonrandomized pilot study. Am J Ther 12:311–319PubMedCrossRef
81.
go back to reference Addington-Hall JM, Rogers A, McCoy A, Gibbs J (2003) Heart disease. In: Morrison RS, Meier DE, Capello C (eds) Geriatric palliative care. Oxford University Press, New York Addington-Hall JM, Rogers A, McCoy A, Gibbs J (2003) Heart disease. In: Morrison RS, Meier DE, Capello C (eds) Geriatric palliative care. Oxford University Press, New York
82.
go back to reference Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ (2006) Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol 48:1527–1537PubMedCrossRef Rutledge T, Reis VA, Linke SE, Greenberg BH, Mills PJ (2006) Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes. J Am Coll Cardiol 48:1527–1537PubMedCrossRef
83.
go back to reference Park SH, Wackernah RC, Stimmel GL (2014) Serotonin syndrome: is it a reason to avoid the use of tramadol with antidepressants? J Pharm Pract 27:71–78PubMedCrossRef Park SH, Wackernah RC, Stimmel GL (2014) Serotonin syndrome: is it a reason to avoid the use of tramadol with antidepressants? J Pharm Pract 27:71–78PubMedCrossRef
84.
go back to reference Connor SR, Pyenson B, Fitch K, Spence C, Iwasaki K (2007) Comparing hospice and nonhospice patient survival among patients who die within a three-year window. J Pain Symptom Manag 33:238–246CrossRef Connor SR, Pyenson B, Fitch K, Spence C, Iwasaki K (2007) Comparing hospice and nonhospice patient survival among patients who die within a three-year window. J Pain Symptom Manag 33:238–246CrossRef
85.
86.
go back to reference Morita T, Tsunoda J, Inoue S, Chihara S (2001) Effects of high dose opioids and sedatives on survival in terminally ill cancer patients. J Pain Symptom Manag 21:282–289CrossRef Morita T, Tsunoda J, Inoue S, Chihara S (2001) Effects of high dose opioids and sedatives on survival in terminally ill cancer patients. J Pain Symptom Manag 21:282–289CrossRef
87.
go back to reference Chan JD, Treece PD, Engelberg RA et al (2004) Narcotic and benzodiazepine use after withdrawal of life support: association with time to death? Chest 126:286–293PubMedCrossRef Chan JD, Treece PD, Engelberg RA et al (2004) Narcotic and benzodiazepine use after withdrawal of life support: association with time to death? Chest 126:286–293PubMedCrossRef
88.
go back to reference (1999) Dyspnea. Mechanisms, assessment, and management: a consensus statement. American Thoracic Society. Am J Respir Crit Care Med 159:321–340 (1999) Dyspnea. Mechanisms, assessment, and management: a consensus statement. American Thoracic Society. Am J Respir Crit Care Med 159:321–340
89.
go back to reference Mann DL (2011) Heart failure: a companion to Braunwald’s heart disease, 2nd edn. Saunders, Philadelphia Mann DL (2011) Heart failure: a companion to Braunwald’s heart disease, 2nd edn. Saunders, Philadelphia
90.
go back to reference Edmonds PM, Rogers A, Addington-Hall JM, McCoy A, Coats AJ, Gibbs JS (2005) Patient descriptions of breathlessness in heart failure. Int J Cardiol 98:61–66PubMedCrossRef Edmonds PM, Rogers A, Addington-Hall JM, McCoy A, Coats AJ, Gibbs JS (2005) Patient descriptions of breathlessness in heart failure. Int J Cardiol 98:61–66PubMedCrossRef
91.
go back to reference Wilcock A, Crosby V, Hughes A, Fielding K, Corcoran R, Tattersfield AE (2002) Descriptors of breathlessness in patients with cancer and other cardiorespiratory diseases. J Pain Symptom Manag 23:182–189CrossRef Wilcock A, Crosby V, Hughes A, Fielding K, Corcoran R, Tattersfield AE (2002) Descriptors of breathlessness in patients with cancer and other cardiorespiratory diseases. J Pain Symptom Manag 23:182–189CrossRef
92.
go back to reference West RL, Hernandez AF, O’Connor CM, Starling RC, Califf RM (2010) A review of dyspnea in acute heart failure syndromes. Am Heart J 160:209–214PubMedCrossRef West RL, Hernandez AF, O’Connor CM, Starling RC, Califf RM (2010) A review of dyspnea in acute heart failure syndromes. Am Heart J 160:209–214PubMedCrossRef
93.
go back to reference Lip G, Zarifis J, Beevers DG (1997) Acute admissions with heart failure to a district general hospital serving a multiracial population. Int J Clin Pract 51:223–227PubMed Lip G, Zarifis J, Beevers DG (1997) Acute admissions with heart failure to a district general hospital serving a multiracial population. Int J Clin Pract 51:223–227PubMed
94.
go back to reference Tataryn D, Chochinov HM (2002) Predicting the trajectory of will to live in terminally ill patients. Psychosomatics 43:370–377PubMedCrossRef Tataryn D, Chochinov HM (2002) Predicting the trajectory of will to live in terminally ill patients. Psychosomatics 43:370–377PubMedCrossRef
95.
go back to reference Reddy SK, Parsons HA, Elsayem A, Palmer JL, Bruera E (2009) Characteristics and correlates of dyspnea in patients with advanced cancer. J Palliat Med 12:29–36PubMedCrossRef Reddy SK, Parsons HA, Elsayem A, Palmer JL, Bruera E (2009) Characteristics and correlates of dyspnea in patients with advanced cancer. J Palliat Med 12:29–36PubMedCrossRef
96.
go back to reference Simon ST, Higginson IJ, Benalia H et al (2013) Episodic and continuous breathlessness: a new categorization of breathlessness. J Pain Symptom Manag 45:1019–1029CrossRef Simon ST, Higginson IJ, Benalia H et al (2013) Episodic and continuous breathlessness: a new categorization of breathlessness. J Pain Symptom Manag 45:1019–1029CrossRef
97.
go back to reference Ezekowitz JA, Hernandez AF, O’Connor CM et al (2012) Assessment of dyspnea in acute decompensated heart failure: insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flow. J Am Coll Cardiol 59:1441–1448PubMedCrossRef Ezekowitz JA, Hernandez AF, O’Connor CM et al (2012) Assessment of dyspnea in acute decompensated heart failure: insights from ASCEND-HF (Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure) on the contributions of peak expiratory flow. J Am Coll Cardiol 59:1441–1448PubMedCrossRef
98.
go back to reference Pang PS, Cleland JG, Teerlink JR et al (2008) A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach. Eur Heart J 29:816–824PubMedCrossRef Pang PS, Cleland JG, Teerlink JR et al (2008) A proposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach. Eur Heart J 29:816–824PubMedCrossRef
99.
go back to reference Witte KK, Clark AL (2007) Why does chronic heart failure cause breathlessness and fatigue? Prog Cardiovasc Dis 49:366–384PubMedCrossRef Witte KK, Clark AL (2007) Why does chronic heart failure cause breathlessness and fatigue? Prog Cardiovasc Dis 49:366–384PubMedCrossRef
100.
go back to reference Gift AG, Narsavage G (1998) Validity of the numeric rating scale as a measure of dyspnea. Am J Crit Care 7:200–204PubMed Gift AG, Narsavage G (1998) Validity of the numeric rating scale as a measure of dyspnea. Am J Crit Care 7:200–204PubMed
101.
go back to reference Wysham NG, Miriovsky BJ, Currow DC et al (2015) Practical dyspnea assessment: relationship between the 0–10 numerical rating scale and the four-level Categorical Verbal Descriptor Scale of dyspnea intensity. J Pain Symptom Manag 50:480–487CrossRef Wysham NG, Miriovsky BJ, Currow DC et al (2015) Practical dyspnea assessment: relationship between the 0–10 numerical rating scale and the four-level Categorical Verbal Descriptor Scale of dyspnea intensity. J Pain Symptom Manag 50:480–487CrossRef
102.
go back to reference Higginson IJ, Bausewein C, Reilly CC et al (2014) An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness: a randomised controlled trial. Lancet Respir Med 2:979–987PubMedCrossRef Higginson IJ, Bausewein C, Reilly CC et al (2014) An integrated palliative and respiratory care service for patients with advanced disease and refractory breathlessness: a randomised controlled trial. Lancet Respir Med 2:979–987PubMedCrossRef
103.
go back to reference von Haehling S, Lainscak M, Springer J, Anker SD (2009) Cardiac cachexia: a systematic overview. Pharmacol Ther 121:227–252CrossRef von Haehling S, Lainscak M, Springer J, Anker SD (2009) Cardiac cachexia: a systematic overview. Pharmacol Ther 121:227–252CrossRef
104.
go back to reference Adamopoulos S, Schmid JP, Dendale P et al (2014) Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: the Vent-HeFT trial: a European prospective multicentre randomized trial. Eur J Heart Fail 16:574–582PubMedCrossRef Adamopoulos S, Schmid JP, Dendale P et al (2014) Combined aerobic/inspiratory muscle training vs. aerobic training in patients with chronic heart failure: the Vent-HeFT trial: a European prospective multicentre randomized trial. Eur J Heart Fail 16:574–582PubMedCrossRef
105.
go back to reference Currow DC, Abernethy AP (2007) Pharmacological management of dyspnoea. Curr Opin Support Palliat Care 1:96–101PubMedCrossRef Currow DC, Abernethy AP (2007) Pharmacological management of dyspnoea. Curr Opin Support Palliat Care 1:96–101PubMedCrossRef
106.
107.
go back to reference Abernethy AP, McDonald CF, Frith PA et al (2010) Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet 376:784–793PubMedPubMedCentralCrossRef Abernethy AP, McDonald CF, Frith PA et al (2010) Effect of palliative oxygen versus room air in relief of breathlessness in patients with refractory dyspnoea: a double-blind, randomised controlled trial. Lancet 376:784–793PubMedPubMedCentralCrossRef
108.
go back to reference Booth S, Wade R, Johnson M et al (2004) The use of oxygen in the palliation of breathlessness. A report of the expert working group of the Scientific Committee of the Association of Palliative Medicine. Respir Med 98:66–77PubMedCrossRef Booth S, Wade R, Johnson M et al (2004) The use of oxygen in the palliation of breathlessness. A report of the expert working group of the Scientific Committee of the Association of Palliative Medicine. Respir Med 98:66–77PubMedCrossRef
109.
go back to reference Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C (2003) Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ 327:523–528PubMedPubMedCentralCrossRef Abernethy AP, Currow DC, Frith P, Fazekas BS, McHugh A, Bui C (2003) Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea. BMJ 327:523–528PubMedPubMedCentralCrossRef
110.
111.
go back to reference Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C (2010) Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev 20(1):CD007354 Simon ST, Higginson IJ, Booth S, Harding R, Bausewein C (2010) Benzodiazepines for the relief of breathlessness in advanced malignant and non-malignant diseases in adults. Cochrane Database Syst Rev 20(1):CD007354
112.
go back to reference Galbraith S, Fagan P, Perkins P, Lynch A, Booth S (2010) Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manag 39:831–838CrossRef Galbraith S, Fagan P, Perkins P, Lynch A, Booth S (2010) Does the use of a handheld fan improve chronic dyspnea? A randomized, controlled, crossover trial. J Pain Symptom Manag 39:831–838CrossRef
113.
go back to reference Dy SM, Apostol CC (2010) Evidence-based approaches to other symptoms in advanced cancer. Cancer J 16:507–513PubMedCrossRef Dy SM, Apostol CC (2010) Evidence-based approaches to other symptoms in advanced cancer. Cancer J 16:507–513PubMedCrossRef
114.
go back to reference Bausewein C, Booth S, Gysels M, Higginson I (2008) Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev 16(2):CD005623 Bausewein C, Booth S, Gysels M, Higginson I (2008) Non-pharmacological interventions for breathlessness in advanced stages of malignant and non-malignant diseases. Cochrane Database Syst Rev 16(2):CD005623
115.
go back to reference Pozehl B, Duncan K, Hertzog M (2008) The effects of exercise training on fatigue and dyspnea in heart failure. Eur J Cardiovasc Nurs 7:127–132PubMedCrossRef Pozehl B, Duncan K, Hertzog M (2008) The effects of exercise training on fatigue and dyspnea in heart failure. Eur J Cardiovasc Nurs 7:127–132PubMedCrossRef
116.
go back to reference Pittler MH, Guo R, Ernst E (2008) Hawthorn extract for treating chronic heart failure. Cochrane Database Syst Rev 23(1):CD005312 Pittler MH, Guo R, Ernst E (2008) Hawthorn extract for treating chronic heart failure. Cochrane Database Syst Rev 23(1):CD005312
117.
go back to reference Bredin M, Corner J, Krishnasamy M, Plant H, Bailey C, A’Hern R (1999) Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. BMJ 318:901–904PubMedPubMedCentralCrossRef Bredin M, Corner J, Krishnasamy M, Plant H, Bailey C, A’Hern R (1999) Multicentre randomised controlled trial of nursing intervention for breathlessness in patients with lung cancer. BMJ 318:901–904PubMedPubMedCentralCrossRef
118.
go back to reference Cahalin LP, Arena RA (2015) Breathing exercises and inspiratory muscle training in heart failure. Heart Fail Clin 11:149–172PubMedCrossRef Cahalin LP, Arena RA (2015) Breathing exercises and inspiratory muscle training in heart failure. Heart Fail Clin 11:149–172PubMedCrossRef
119.
go back to reference Bausewein C, Jolley C, Reilly C et al (2012) Development, effectiveness and cost-effectiveness of a new out-patient Breathlessness Support Service: study protocol of a phase III fast-track randomised controlled trial. BMC Pulm Med 12:58PubMedPubMedCentralCrossRef Bausewein C, Jolley C, Reilly C et al (2012) Development, effectiveness and cost-effectiveness of a new out-patient Breathlessness Support Service: study protocol of a phase III fast-track randomised controlled trial. BMC Pulm Med 12:58PubMedPubMedCentralCrossRef
120.
go back to reference Holzapfel N, Muller-Tasch T, Wild B et al (2008) Depression profile in patients with and without chronic heart failure. J Affect Disord 105:53–62PubMedCrossRef Holzapfel N, Muller-Tasch T, Wild B et al (2008) Depression profile in patients with and without chronic heart failure. J Affect Disord 105:53–62PubMedCrossRef
121.
go back to reference Faris R, Purcell H, Henein MY, Coats AJ (2002) Clinical depression is common and significantly associated with reduced survival in patients with non-ischaemic heart failure. Eur J Heart Fail 4:541–551PubMedCrossRef Faris R, Purcell H, Henein MY, Coats AJ (2002) Clinical depression is common and significantly associated with reduced survival in patients with non-ischaemic heart failure. Eur J Heart Fail 4:541–551PubMedCrossRef
122.
go back to reference Rumsfeld JS, Havranek E, Masoudi FA et al (2003) Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. J Am Coll Cardiol 42:1811–1817PubMedCrossRef Rumsfeld JS, Havranek E, Masoudi FA et al (2003) Depressive symptoms are the strongest predictors of short-term declines in health status in patients with heart failure. J Am Coll Cardiol 42:1811–1817PubMedCrossRef
123.
go back to reference Murberg TA, Bru E, Svebak S, Tveteras R, Aarsland T (1999) Depressed mood and subjective health symptoms as predictors of mortality in patients with congestive heart failure: a two-years follow-up study. Int J Psychiatry Med 29:311–326PubMedCrossRef Murberg TA, Bru E, Svebak S, Tveteras R, Aarsland T (1999) Depressed mood and subjective health symptoms as predictors of mortality in patients with congestive heart failure: a two-years follow-up study. Int J Psychiatry Med 29:311–326PubMedCrossRef
124.
go back to reference Sullivan M, Simon G, Spertus J, Russo J (2002) Depression-related costs in heart failure care. Arch Intern Med 162:1860–1866PubMedCrossRef Sullivan M, Simon G, Spertus J, Russo J (2002) Depression-related costs in heart failure care. Arch Intern Med 162:1860–1866PubMedCrossRef
125.
go back to reference Carels RA, Musher-Eizenman D, Cacciapaglia H, Perez-Benitez CI, Christie S, O’Brien W (2004) Psychosocial functioning and physical symptoms in heart failure patients: a within-individual approach. J Psychosom Res 56:95–101PubMedCrossRef Carels RA, Musher-Eizenman D, Cacciapaglia H, Perez-Benitez CI, Christie S, O’Brien W (2004) Psychosocial functioning and physical symptoms in heart failure patients: a within-individual approach. J Psychosom Res 56:95–101PubMedCrossRef
126.
go back to reference Muller-Tasch T, Peters-Klimm F, Schellberg D et al (2007) Depression is a major determinant of quality of life in patients with chronic systolic heart failure in general practice. J Card Fail 13:818–824PubMedCrossRef Muller-Tasch T, Peters-Klimm F, Schellberg D et al (2007) Depression is a major determinant of quality of life in patients with chronic systolic heart failure in general practice. J Card Fail 13:818–824PubMedCrossRef
127.
go back to reference Jiang W, Alexander J, Christopher E et al (2001) Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch Intern Med 161:1849–1856PubMedCrossRef Jiang W, Alexander J, Christopher E et al (2001) Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch Intern Med 161:1849–1856PubMedCrossRef
129.
go back to reference Lowey SE, Norton SA, Quinn JR, Quill TE (2013) Living with advanced heart failure or COPD: experiences and goals of individuals nearing the end of life. Res Nurs Health 36:349–358PubMedCrossRef Lowey SE, Norton SA, Quinn JR, Quill TE (2013) Living with advanced heart failure or COPD: experiences and goals of individuals nearing the end of life. Res Nurs Health 36:349–358PubMedCrossRef
130.
go back to reference Herman JG (1987) New oxygen delivery systems. Gaining patient compliance. Respir Manag 17(30–9):64 Herman JG (1987) New oxygen delivery systems. Gaining patient compliance. Respir Manag 17(30–9):64
131.
go back to reference Logan PA, Dyas J, Gladman JR (2004) Using an interview study of transport use by people who have had a stroke to inform rehabilitation. Clin Rehabil 18:703–708PubMedCrossRef Logan PA, Dyas J, Gladman JR (2004) Using an interview study of transport use by people who have had a stroke to inform rehabilitation. Clin Rehabil 18:703–708PubMedCrossRef
132.
go back to reference Sears SF, Hauf JD, Kirian K, Hazelton G, Conti JB (2011) Posttraumatic stress and the implantable cardioverter-defibrillator patient: what the electrophysiologist needs to know. Circ Arrhythm Electrophysiol 4:242–250PubMedCrossRef Sears SF, Hauf JD, Kirian K, Hazelton G, Conti JB (2011) Posttraumatic stress and the implantable cardioverter-defibrillator patient: what the electrophysiologist needs to know. Circ Arrhythm Electrophysiol 4:242–250PubMedCrossRef
133.
go back to reference Kroenke K, Spitzer RL, Williams JB (2003) The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 41:1284–1292PubMedCrossRef Kroenke K, Spitzer RL, Williams JB (2003) The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care 41:1284–1292PubMedCrossRef
135.
go back to reference O’Connor CM, Jiang W, Kuchibhatla M et al (2010) Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol 56:692–699PubMedPubMedCentralCrossRef O’Connor CM, Jiang W, Kuchibhatla M et al (2010) Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial. J Am Coll Cardiol 56:692–699PubMedPubMedCentralCrossRef
136.
go back to reference Reynolds CF 3rd, Dew MA, Pollock BG et al (2006) Maintenance treatment of major depression in old age. N Engl J Med 354:1130–1138PubMedCrossRef Reynolds CF 3rd, Dew MA, Pollock BG et al (2006) Maintenance treatment of major depression in old age. N Engl J Med 354:1130–1138PubMedCrossRef
137.
go back to reference Angermann CE, Gelbrich G, Stork S et al (2016) Effect of escitalopram on all-cause mortality and hospitalization in patients with heart failure and depression: the MOOD-HF randomized clinical trial. JAMA 315:2683–2693PubMedCrossRef Angermann CE, Gelbrich G, Stork S et al (2016) Effect of escitalopram on all-cause mortality and hospitalization in patients with heart failure and depression: the MOOD-HF randomized clinical trial. JAMA 315:2683–2693PubMedCrossRef
138.
go back to reference Jacob S, Spinler SA (2006) Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother 40:1618–1622PubMedCrossRef Jacob S, Spinler SA (2006) Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults. Ann Pharmacother 40:1618–1622PubMedCrossRef
139.
go back to reference Funk KA, Bostwick JR (2013) A comparison of the risk of QT prolongation among SSRIs. Ann Pharmacother 47:1330–1341PubMedCrossRef Funk KA, Bostwick JR (2013) A comparison of the risk of QT prolongation among SSRIs. Ann Pharmacother 47:1330–1341PubMedCrossRef
140.
go back to reference Marken PA, Munro JS (2000) Selecting a selective serotonin reuptake inhibitor: clinically important distinguishing features. Prim Care Companion J Clin Psychiatry 2:205–210PubMedPubMedCentralCrossRef Marken PA, Munro JS (2000) Selecting a selective serotonin reuptake inhibitor: clinically important distinguishing features. Prim Care Companion J Clin Psychiatry 2:205–210PubMedPubMedCentralCrossRef
141.
go back to reference Colucci VJ, Berry BD (2008) Heart failure worsening and exacerbation after venlafaxine and duloxetine therapy. Ann Pharmacother 42:882–887PubMedCrossRef Colucci VJ, Berry BD (2008) Heart failure worsening and exacerbation after venlafaxine and duloxetine therapy. Ann Pharmacother 42:882–887PubMedCrossRef
142.
go back to reference Harris J, Heil JS (2013) Managing depression in patients with advanced heart failure awaiting transplantation. Am J Health Syst Pharm 70:867–873PubMedCrossRef Harris J, Heil JS (2013) Managing depression in patients with advanced heart failure awaiting transplantation. Am J Health Syst Pharm 70:867–873PubMedCrossRef
143.
go back to reference Qaseem A, Barry MJ, Kansagara D (2016) Clinical Guidelines Committee of the American College of P. Nonpharmacologic versus pharmacologic treatment of adult patients with major depressive disorder: a clinical practice guideline from the American College of Physicians. Ann Intern Med 164:350–359PubMedCrossRef Qaseem A, Barry MJ, Kansagara D (2016) Clinical Guidelines Committee of the American College of P. Nonpharmacologic versus pharmacologic treatment of adult patients with major depressive disorder: a clinical practice guideline from the American College of Physicians. Ann Intern Med 164:350–359PubMedCrossRef
144.
go back to reference O’Connor CM, Joynt KE (2004) Depression: are we ignoring an important comorbidity in heart failure? J Am Coll Cardiol 43:1550–1552PubMedCrossRef O’Connor CM, Joynt KE (2004) Depression: are we ignoring an important comorbidity in heart failure? J Am Coll Cardiol 43:1550–1552PubMedCrossRef
146.
go back to reference Lundgren J, Andersson G, Johansson P (2015) Can cognitive behaviour therapy be beneficial for heart failure patients? Curr Heart Fail Rep 12:166–172PubMedCrossRef Lundgren J, Andersson G, Johansson P (2015) Can cognitive behaviour therapy be beneficial for heart failure patients? Curr Heart Fail Rep 12:166–172PubMedCrossRef
147.
148.
go back to reference Sullivan MJ, Wood L, Terry J et al (2009) The support, education, and research in chronic heart failure study (SEARCH): a mindfulness-based psychoeducational intervention improves depression and clinical symptoms in patients with chronic heart failure. Am Heart J 157:84–90PubMedCrossRef Sullivan MJ, Wood L, Terry J et al (2009) The support, education, and research in chronic heart failure study (SEARCH): a mindfulness-based psychoeducational intervention improves depression and clinical symptoms in patients with chronic heart failure. Am Heart J 157:84–90PubMedCrossRef
149.
go back to reference Lane DA, Chong AY, Lip GY (2005) Psychological interventions for depression in heart failure. Cochrane Database Syst Rev 25(1):CD003329 Lane DA, Chong AY, Lip GY (2005) Psychological interventions for depression in heart failure. Cochrane Database Syst Rev 25(1):CD003329
150.
go back to reference Goodlin SJ, Hauptman PJ, Arnold R et al (2004) Consensus statement: palliative and supportive care in advanced heart failure. J Card Fail 10:200–209PubMedCrossRef Goodlin SJ, Hauptman PJ, Arnold R et al (2004) Consensus statement: palliative and supportive care in advanced heart failure. J Card Fail 10:200–209PubMedCrossRef
151.
go back to reference Stevenson LW, O’Donnell A (2015) Advanced care planning: care to plan in advance. JACC Heart Fail 3:122–126PubMedCrossRef Stevenson LW, O’Donnell A (2015) Advanced care planning: care to plan in advance. JACC Heart Fail 3:122–126PubMedCrossRef
152.
go back to reference Kirkpatrick JN, Gottlieb M, Sehgal P, Patel R, Verdino RJ (2012) Deactivation of implantable cardioverter defibrillators in terminal illness and end of life care. Am J Cardiol 109:91–94PubMedCrossRef Kirkpatrick JN, Gottlieb M, Sehgal P, Patel R, Verdino RJ (2012) Deactivation of implantable cardioverter defibrillators in terminal illness and end of life care. Am J Cardiol 109:91–94PubMedCrossRef
153.
go back to reference Bekelman DB, Plomondon ME, Carey EP et al (2015) Primary results of the patient-centered disease management (PCDM) for heart failure study: a randomized clinical trial. JAMA Intern Med 175:725–732PubMedCrossRef Bekelman DB, Plomondon ME, Carey EP et al (2015) Primary results of the patient-centered disease management (PCDM) for heart failure study: a randomized clinical trial. JAMA Intern Med 175:725–732PubMedCrossRef
154.
go back to reference Gavazzi A, De Maria R, Manzoli L et al (2015) Palliative needs for heart failure or chronic obstructive pulmonary disease: results of a multicenter observational registry. Int J Cardiol 184:552–558PubMedCrossRef Gavazzi A, De Maria R, Manzoli L et al (2015) Palliative needs for heart failure or chronic obstructive pulmonary disease: results of a multicenter observational registry. Int J Cardiol 184:552–558PubMedCrossRef
155.
go back to reference Sandek A, Swidsinski A, Schroedl W et al (2014) Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia. J Am Coll Cardiol 64:1092–1102PubMedCrossRef Sandek A, Swidsinski A, Schroedl W et al (2014) Intestinal blood flow in patients with chronic heart failure: a link with bacterial growth, gastrointestinal symptoms, and cachexia. J Am Coll Cardiol 64:1092–1102PubMedCrossRef
156.
go back to reference Halpin A, Huckabay LM, Kozuki JL, Forsythe D (2010) Weigh the benefits of using a 0-to-5 nausea scale. Nursing 40:18–20PubMedCrossRef Halpin A, Huckabay LM, Kozuki JL, Forsythe D (2010) Weigh the benefits of using a 0-to-5 nausea scale. Nursing 40:18–20PubMedCrossRef
157.
go back to reference Meiri E, Jhangiani H, Vredenburgh JJ et al (2007) Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting. Curr Med Res Opin 23:533–543PubMedCrossRef Meiri E, Jhangiani H, Vredenburgh JJ et al (2007) Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting. Curr Med Res Opin 23:533–543PubMedCrossRef
159.
go back to reference Coffin B, Causse C (2011) Constipation assessment scales in adults: a literature review including the new Bowel Function Index. Expert Rev Gastroenterol Hepatol 5:601–613PubMedCrossRef Coffin B, Causse C (2011) Constipation assessment scales in adults: a literature review including the new Bowel Function Index. Expert Rev Gastroenterol Hepatol 5:601–613PubMedCrossRef
160.
go back to reference Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L (2013) American College of G. Clinical guideline: management of gastroparesis. Am J Gastroenterol 108:18–37 (quiz 38) PubMedCrossRef Camilleri M, Parkman HP, Shafi MA, Abell TL, Gerson L (2013) American College of G. Clinical guideline: management of gastroparesis. Am J Gastroenterol 108:18–37 (quiz 38) PubMedCrossRef
161.
162.
163.
go back to reference Stimmel GL, Dopheide JA, Stahl SM (1997) Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy 17:10–21PubMed Stimmel GL, Dopheide JA, Stahl SM (1997) Mirtazapine: an antidepressant with noradrenergic and specific serotonergic effects. Pharmacotherapy 17:10–21PubMed
164.
go back to reference Beal JE, Olson R, Lefkowitz L et al (1997) Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. J Pain Symptom Manag 14:7–14CrossRef Beal JE, Olson R, Lefkowitz L et al (1997) Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. J Pain Symptom Manag 14:7–14CrossRef
165.
go back to reference Thomas DR (2004) Incidence of venous thromboembolism in megestrol acetate users. J Am Med Dir Assoc 5:65–66 (author reply 66–67) PubMedCrossRef Thomas DR (2004) Incidence of venous thromboembolism in megestrol acetate users. J Am Med Dir Assoc 5:65–66 (author reply 66–67) PubMedCrossRef
166.
go back to reference Doehner W, Frenneaux M, Anker SD (2014) Metabolic impairment in heart failure: the myocardial and systemic perspective. J Am Coll Cardiol 64:1388–1400PubMedCrossRef Doehner W, Frenneaux M, Anker SD (2014) Metabolic impairment in heart failure: the myocardial and systemic perspective. J Am Coll Cardiol 64:1388–1400PubMedCrossRef
167.
go back to reference Kohnlein T, Welte T, Tan LB, Elliott MW (2002) Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature. Thorax 57:547–554PubMedPubMedCentralCrossRef Kohnlein T, Welte T, Tan LB, Elliott MW (2002) Central sleep apnoea syndrome in patients with chronic heart disease: a critical review of the current literature. Thorax 57:547–554PubMedPubMedCentralCrossRef
168.
go back to reference Shah AB, Morrissey RP, Baraghoush A et al (2013) Failing the failing heart: a review of palliative care in heart failure. Rev Cardiovasc Med 14:41–48PubMedCrossRef Shah AB, Morrissey RP, Baraghoush A et al (2013) Failing the failing heart: a review of palliative care in heart failure. Rev Cardiovasc Med 14:41–48PubMedCrossRef
169.
go back to reference Falk K, Patel H, Swedberg K, Ekman I (2009) Fatigue in patients with chronic heart failure—a burden associated with emotional and symptom distress. Eur J Cardiovasc Nurs 8:91–96PubMedCrossRef Falk K, Patel H, Swedberg K, Ekman I (2009) Fatigue in patients with chronic heart failure—a burden associated with emotional and symptom distress. Eur J Cardiovasc Nurs 8:91–96PubMedCrossRef
170.
go back to reference Mansfield DR, Gollogly NC, Kaye DM, Richardson M, Bergin P, Naughton MT (2004) Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 169:361–366PubMedCrossRef Mansfield DR, Gollogly NC, Kaye DM, Richardson M, Bergin P, Naughton MT (2004) Controlled trial of continuous positive airway pressure in obstructive sleep apnea and heart failure. Am J Respir Crit Care Med 169:361–366PubMedCrossRef
171.
go back to reference Lennie TA, Moser DK, Biddle MJ et al (2013) Nutrition intervention to decrease symptoms in patients with advanced heart failure. Res Nurs Health 36:120–145PubMedPubMedCentralCrossRef Lennie TA, Moser DK, Biddle MJ et al (2013) Nutrition intervention to decrease symptoms in patients with advanced heart failure. Res Nurs Health 36:120–145PubMedPubMedCentralCrossRef
172.
go back to reference Toyama T, Seki R, Kasama S et al (2009) Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea. Circ J 73:299–304PubMedCrossRef Toyama T, Seki R, Kasama S et al (2009) Effectiveness of nocturnal home oxygen therapy to improve exercise capacity, cardiac function and cardiac sympathetic nerve activity in patients with chronic heart failure and central sleep apnea. Circ J 73:299–304PubMedCrossRef
173.
go back to reference Nymark TB, Hovland A, Bjornstad H, Nielsen EW (2008) A young man with acute dilated cardiomyopathy associated with methylphenidate. Vasc Health Risk Manag 4:477–479PubMedPubMedCentralCrossRef Nymark TB, Hovland A, Bjornstad H, Nielsen EW (2008) A young man with acute dilated cardiomyopathy associated with methylphenidate. Vasc Health Risk Manag 4:477–479PubMedPubMedCentralCrossRef
174.
go back to reference Come CE, Shapiro PA (2005) Supraventricular tachycardia associated with methylphenidate treatment in a heart transplant recipient. Psychosomatics 46:461–463PubMedCrossRef Come CE, Shapiro PA (2005) Supraventricular tachycardia associated with methylphenidate treatment in a heart transplant recipient. Psychosomatics 46:461–463PubMedCrossRef
175.
go back to reference Thompson J, Thompson JR (2010) Acute myocardial infarction related to methylphenidate for adult attention deficit disorder. J Emerg Med 38:18–21PubMedCrossRef Thompson J, Thompson JR (2010) Acute myocardial infarction related to methylphenidate for adult attention deficit disorder. J Emerg Med 38:18–21PubMedCrossRef
176.
go back to reference Schelleman H, Bilker WB, Kimmel SE et al (2012) Methylphenidate and risk of serious cardiovascular events in adults. Am J Psychiatry 169:178–185PubMedCrossRef Schelleman H, Bilker WB, Kimmel SE et al (2012) Methylphenidate and risk of serious cardiovascular events in adults. Am J Psychiatry 169:178–185PubMedCrossRef
177.
go back to reference Pharmaceuticals J. Package insert: CONCERTA. 2000 (revised 12/2013) Pharmaceuticals J. Package insert: CONCERTA. 2000 (revised 12/2013)
178.
go back to reference Dzida G, Prystupa A, Lachowska-Kotowska P et al (2013) Alteration in diurnal and nocturnal melatonin serum level in patients with chronic heart failure. Ann Agric Environ Med 20:745–748PubMed Dzida G, Prystupa A, Lachowska-Kotowska P et al (2013) Alteration in diurnal and nocturnal melatonin serum level in patients with chronic heart failure. Ann Agric Environ Med 20:745–748PubMed
179.
go back to reference Abete P, Bianco S, Calabrese C et al (1997) Effects of melatonin in isolated rat papillary muscle. FEBS Lett 412:79–85PubMedCrossRef Abete P, Bianco S, Calabrese C et al (1997) Effects of melatonin in isolated rat papillary muscle. FEBS Lett 412:79–85PubMedCrossRef
180.
go back to reference Khan RF, Feder S, Goldstein NE, Chaudhry SI (2015) Symptom burden among patients who were hospitalized for heart failure. JAMA Intern Med 175:1713–1715PubMedCrossRef Khan RF, Feder S, Goldstein NE, Chaudhry SI (2015) Symptom burden among patients who were hospitalized for heart failure. JAMA Intern Med 175:1713–1715PubMedCrossRef
181.
go back to reference Desbiens NA, Wu AW, Alzola C et al (1997) Pain during hospitalization is associated with continued pain six months later in survivors of serious illness. The SUPPORT investigators. Study to understand prognoses and preferences for outcomes and risks of treatments. Am J Med 102:269–276PubMedCrossRef Desbiens NA, Wu AW, Alzola C et al (1997) Pain during hospitalization is associated with continued pain six months later in survivors of serious illness. The SUPPORT investigators. Study to understand prognoses and preferences for outcomes and risks of treatments. Am J Med 102:269–276PubMedCrossRef
182.
go back to reference Pantilat SZ, O’Riordan DL, Dibble SL, Landefeld CS (2012) Longitudinal assessment of symptom severity among hospitalized elders diagnosed with cancer, heart failure, and chronic obstructive pulmonary disease. J Hosp Med 7:567–572PubMedCrossRef Pantilat SZ, O’Riordan DL, Dibble SL, Landefeld CS (2012) Longitudinal assessment of symptom severity among hospitalized elders diagnosed with cancer, heart failure, and chronic obstructive pulmonary disease. J Hosp Med 7:567–572PubMedCrossRef
183.
go back to reference Hauptman PJ, Havranek EP (2005) Integrating palliative care into heart failure care. Arch Intern Med 165:374–378PubMedCrossRef Hauptman PJ, Havranek EP (2005) Integrating palliative care into heart failure care. Arch Intern Med 165:374–378PubMedCrossRef
184.
go back to reference Casarett D, Pickard A, Bailey FA et al (2008) Do palliative consultations improve patient outcomes? J Am Geriatr Soc 56:593–599PubMedCrossRef Casarett D, Pickard A, Bailey FA et al (2008) Do palliative consultations improve patient outcomes? J Am Geriatr Soc 56:593–599PubMedCrossRef
185.
go back to reference Pirl WF, Greer JA, Traeger L et al (2012) Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care. J Clin Oncol 30:1310–1315PubMedPubMedCentralCrossRef Pirl WF, Greer JA, Traeger L et al (2012) Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care. J Clin Oncol 30:1310–1315PubMedPubMedCentralCrossRef
186.
go back to reference Sidebottom AC, Jorgenson A, Richards H, Kirven J, Sillah A (2015) Inpatient palliative care for patients with acute heart failure: outcomes from a randomized trial. J Palliat Med 18:134–142PubMedCrossRef Sidebottom AC, Jorgenson A, Richards H, Kirven J, Sillah A (2015) Inpatient palliative care for patients with acute heart failure: outcomes from a randomized trial. J Palliat Med 18:134–142PubMedCrossRef
187.
go back to reference Evangelista LS, Liao S, Motie M, De Michelis N, Ballard-Hernandez J, Lombardo D (2014) Does the type and frequency of palliative care services received by patients with advanced heart failure impact symptom burden? J Palliat Med 17:75–79PubMedPubMedCentralCrossRef Evangelista LS, Liao S, Motie M, De Michelis N, Ballard-Hernandez J, Lombardo D (2014) Does the type and frequency of palliative care services received by patients with advanced heart failure impact symptom burden? J Palliat Med 17:75–79PubMedPubMedCentralCrossRef
188.
go back to reference Rutten FH, Heddema WS, Daggelders GJ, Hoes AW (2012) Primary care patients with heart failure in the last year of their life. Fam Pract 29:36–42PubMedCrossRef Rutten FH, Heddema WS, Daggelders GJ, Hoes AW (2012) Primary care patients with heart failure in the last year of their life. Fam Pract 29:36–42PubMedCrossRef
189.
go back to reference Mentz RJ, Tulsky JA, Granger BB et al (2014) The palliative care in heart failure trial: rationale and design. Am Heart J 168(645–651):e1 Mentz RJ, Tulsky JA, Granger BB et al (2014) The palliative care in heart failure trial: rationale and design. Am Heart J 168(645–651):e1
190.
go back to reference Riegel B, Moser DK, Powell M, Rector TS, Havranek EP (2006) Nonpharmacologic care by heart failure experts. J Card Fail 12:149–153PubMed Riegel B, Moser DK, Powell M, Rector TS, Havranek EP (2006) Nonpharmacologic care by heart failure experts. J Card Fail 12:149–153PubMed
191.
go back to reference Kavalieratos D, Mitchell EM, Carey TS et al (2014) “Not the ‘grim reaper service’”: an assessment of provider knowledge, attitudes, and perceptions regarding palliative care referral barriers in heart failure. J Am Heart Assoc 3:e000544PubMedPubMedCentralCrossRef Kavalieratos D, Mitchell EM, Carey TS et al (2014) “Not the ‘grim reaper service’”: an assessment of provider knowledge, attitudes, and perceptions regarding palliative care referral barriers in heart failure. J Am Heart Assoc 3:e000544PubMedPubMedCentralCrossRef
192.
go back to reference Kamal AH, Maguire JM, Meier DE (2015) Evolving the palliative care workforce to provide responsive, serious illness care. Ann Intern Med 163:637–638PubMedCrossRef Kamal AH, Maguire JM, Meier DE (2015) Evolving the palliative care workforce to provide responsive, serious illness care. Ann Intern Med 163:637–638PubMedCrossRef
193.
go back to reference Kamal AH, Bull J, Wolf S et al (2016) Characterizing the hospice and palliative care workforce in the U.S.: clinician demographics and professional responsibilities. J Pain Symptom Manag 51:597–603CrossRef Kamal AH, Bull J, Wolf S et al (2016) Characterizing the hospice and palliative care workforce in the U.S.: clinician demographics and professional responsibilities. J Pain Symptom Manag 51:597–603CrossRef
194.
go back to reference Quill TE, Abernethy AP (2013) Generalist plus specialist palliative care–creating a more sustainable model. N Engl J Med 368:1173–1175PubMedCrossRef Quill TE, Abernethy AP (2013) Generalist plus specialist palliative care–creating a more sustainable model. N Engl J Med 368:1173–1175PubMedCrossRef
195.
go back to reference Whellan DJ, Goodlin SJ, Dickinson MG et al (2014) End-of-life care in patients with heart failure. J Card Fail 20:121–134PubMedCrossRef Whellan DJ, Goodlin SJ, Dickinson MG et al (2014) End-of-life care in patients with heart failure. J Card Fail 20:121–134PubMedCrossRef
197.
go back to reference Dev S, Abernethy AP, Rogers JG, O’Connor CM (2012) Preferences of people with advanced heart failure-a structured narrative literature review to inform decision making in the palliative care setting. Am Heart J 164(313–319):e5 Dev S, Abernethy AP, Rogers JG, O’Connor CM (2012) Preferences of people with advanced heart failure-a structured narrative literature review to inform decision making in the palliative care setting. Am Heart J 164(313–319):e5
198.
go back to reference Munoz-Mendoza J (2015) Competencies in palliative care for cardiology fellows. J Am Coll Cardiol 65:750–752PubMedCrossRef Munoz-Mendoza J (2015) Competencies in palliative care for cardiology fellows. J Am Coll Cardiol 65:750–752PubMedCrossRef
199.
200.
go back to reference Fallowfield LJ (2000) How to improve the communication skills of oncologists. Ann Oncol 11(Suppl 3):63–66PubMedCrossRef Fallowfield LJ (2000) How to improve the communication skills of oncologists. Ann Oncol 11(Suppl 3):63–66PubMedCrossRef
201.
go back to reference Butler J, Binney Z, Kalogeropoulos A et al (2015) Advance directives among hospitalized patients with heart failure. JACC Heart Fail 3:112–121PubMedCrossRef Butler J, Binney Z, Kalogeropoulos A et al (2015) Advance directives among hospitalized patients with heart failure. JACC Heart Fail 3:112–121PubMedCrossRef
Metadata
Title
Symptom burden in heart failure: assessment, impact on outcomes, and management
Authors
Craig M. Alpert
Michael A. Smith
Scott L. Hummel
Ellen K. Hummel
Publication date
01-01-2017
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 1/2017
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-016-9581-4

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