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01-01-2016

A perspective on sympathetic renal denervation in chronic congestive heart failure

Authors: Raef Madanieh, Mohammed El-Hunjul, Hassan Alkhawam, Constantine E. Kosmas, Abed Madanieh, Timothy J. Vittorio

Published in: Heart Failure Reviews | Issue 1/2016

Abstract

Medical therapy has indisputably been the mainstay of management for chronic congestive heart failure. However, a significant percentage of patients continue to experience worsening heart failure (HF) symptoms despite treatment with multiple therapeutic agents. Recently, catheter-based interventional strategies that interrupt the renal sympathetic nervous system have shown promising results in providing better symptom control in patients with HF. In this article, we will review the pathophysiology of HF for better understanding of the interplay between the cardiovascular system and the kidney. Subsequently, we will briefly discuss pivotal renal denervation (RDN) therapy trials in patients with resistant hypertension and then present the available evidence on the role of RDN in HF therapy.

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Title: A perspective on sympathetic renal denervation in chronic congestive heart failure
Authors: Raef Madanieh
Mohammed El-Hunjul
Hassan Alkhawam
Constantine E. Kosmas
Abed Madanieh
Timothy J. Vittorio
Publication date: 01-01-2016
Publisher: Springer US
Published in: Heart Failure Reviews / Issue 1/2016
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-015-9516-5

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