Skip to main content
Top
Published in: Heart Failure Reviews 3/2012

01-05-2012

The dilemma, causes and approaches to avoid recurrent hospital readmissions for patients with chronic heart failure

Authors: Melody Zaya, Anita Phan, Ernst R. Schwarz

Published in: Heart Failure Reviews | Issue 3/2012

Login to get access

Abstract

Heart failure is a progressive illness that carries significant morbidity and mortality. This highly prevalent illness leads to frequent, costly hospitalizations with approximately 50% of patients being readmitted within 6 months of initial hospitalization. While rehospitalization has been extensively studied in the past, little progress has been made in terms of reducing readmission rates of heart failure patients in the last decade despite increasing costs with impending resource limitations. We discuss disease-centered, physician-centered, and patient-centered factors that lead to rehospitalization as well as community/resource availability factors that contribute to rehospitalization of patients suffering from chronic heart failure. In addition, predictors of hospitalization and interventions that reduce hospitalization will be critically evaluated. With a complete understanding of heart failure rehospitalization, we hope the future holds more effective ways to prevent heart failure progression and thus rehospitalization, improved risk-stratification models to identify patients high-risk for rehospitalization, and sustained interventions that are customized according to the etiology of the clinical decline of heart failure patients that ultimately results in frequent rehospitalizations.
Literature
1.
go back to reference American Heart Association. Heart disease and stroke statistics-2009 update (2009) Circulation 119:e21–e181 American Heart Association. Heart disease and stroke statistics-2009 update (2009) Circulation 119:e21–e181
2.
go back to reference American Heart Association. Heart disease and stroke statistics–2005 update. Dallas, TX: American Heart Association; 2005 American Heart Association. Heart disease and stroke statistics–2005 update. Dallas, TX: American Heart Association; 2005
3.
go back to reference Merrill CT, Elixhauser A. Hospitalization in the United States, 2002: HCUP Fact Book No. 6. Rockville, MD: Agency for Healthcare Research and Quality; 2005. AHRQ publication 05-0056 Merrill CT, Elixhauser A. Hospitalization in the United States, 2002: HCUP Fact Book No. 6. Rockville, MD: Agency for Healthcare Research and Quality; 2005. AHRQ publication 05-0056
4.
go back to reference O’Connell JB, Bristow MR (1994) Economic impact of heart failure in the United States: time for a different approach. J Heart Lung Transplant 13:S107–S111PubMed O’Connell JB, Bristow MR (1994) Economic impact of heart failure in the United States: time for a different approach. J Heart Lung Transplant 13:S107–S111PubMed
5.
go back to reference Keenan PS, Normand SL, Lin Z et al (2008) An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure. Circ Cardiovasc Qual Outcomes 1:29–37PubMedCrossRef Keenan PS, Normand SL, Lin Z et al (2008) An administrative claims measure suitable for profiling hospital performance on the basis of 30-day all-cause readmission rates among patients with heart failure. Circ Cardiovasc Qual Outcomes 1:29–37PubMedCrossRef
6.
go back to reference Jencks SF, Williams MV, Coleman EA (2009) Rehospitalizations among patients in the medicare fee-for-service program. N Engl J Med 360:1418–1428PubMedCrossRef Jencks SF, Williams MV, Coleman EA (2009) Rehospitalizations among patients in the medicare fee-for-service program. N Engl J Med 360:1418–1428PubMedCrossRef
7.
go back to reference Hunt SA, Abraham WT, Chin MH et al (2009) 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. doi: 10.1161/CIRCULATIONAHA.109.192065 Hunt SA, Abraham WT, Chin MH et al (2009) 2009 Focused update incorporated into the ACC/AHA 2005 guidelines for the diagnosis and management of heart failure in adults. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. doi: 10.​1161/​CIRCULATIONAHA.​109.​192065
8.
go back to reference Sutton MGSJ, Sharper N (2000) Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101:2981–2988PubMed Sutton MGSJ, Sharper N (2000) Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101:2981–2988PubMed
9.
go back to reference Eichhorn EJ, Bristow MR (1996) Medical therapy can improve the biologic function properties of the chronically failing heart: a new era in the treatment of heart failure. Circulation 94:2285–2296PubMed Eichhorn EJ, Bristow MR (1996) Medical therapy can improve the biologic function properties of the chronically failing heart: a new era in the treatment of heart failure. Circulation 94:2285–2296PubMed
10.
go back to reference Schwarz ER, Schaper J, vom Dahl J et al (1996) Myocyte degeneration and cell death in hibernating human myocardium. J Am Coll Cardiol 7:1577–1585CrossRef Schwarz ER, Schaper J, vom Dahl J et al (1996) Myocyte degeneration and cell death in hibernating human myocardium. J Am Coll Cardiol 7:1577–1585CrossRef
11.
go back to reference Schwarz ER, Schoendube FA, Kostin S (1998) Prolonged myocardial hibernation exacerbates cardiomyocyte degeneration and impairs recovery of function after revascularization. J Am Coll Cardiol 5:1018–1026CrossRef Schwarz ER, Schoendube FA, Kostin S (1998) Prolonged myocardial hibernation exacerbates cardiomyocyte degeneration and impairs recovery of function after revascularization. J Am Coll Cardiol 5:1018–1026CrossRef
12.
go back to reference Witte KKA, Clark AL, Cleland JGF (2001) Chronic heart failure and micronutrients. J Am Coll Cardiol 37:1765–1774PubMedCrossRef Witte KKA, Clark AL, Cleland JGF (2001) Chronic heart failure and micronutrients. J Am Coll Cardiol 37:1765–1774PubMedCrossRef
13.
go back to reference Bhattacharya SK, Ahokas RA, Carbone LD et al (2006) Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev 1:45–55CrossRef Bhattacharya SK, Ahokas RA, Carbone LD et al (2006) Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev 1:45–55CrossRef
14.
go back to reference Tsutsui H, Tsuchihashi M, Takeshita A (2001) Mortality and readmission of hospitalized patients with congestive heart failure and preserved versus depressed systolic function. Am J Cardiol 88:530–533PubMedCrossRef Tsutsui H, Tsuchihashi M, Takeshita A (2001) Mortality and readmission of hospitalized patients with congestive heart failure and preserved versus depressed systolic function. Am J Cardiol 88:530–533PubMedCrossRef
16.
go back to reference Maisel WH, Stevenson LW (2003) Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol 91(6A):2D–8D Maisel WH, Stevenson LW (2003) Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol 91(6A):2D–8D
18.
go back to reference Aranda JM Jr, Johnson JW, Conti JB (2009) Current trends in heart failure readmission rates: analysis of medicare data. Clin Cardiol 32(1):47–52PubMedCrossRef Aranda JM Jr, Johnson JW, Conti JB (2009) Current trends in heart failure readmission rates: analysis of medicare data. Clin Cardiol 32(1):47–52PubMedCrossRef
19.
go back to reference Young T, Peppard P, Palta M et al (1997) Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 157:1746–1752PubMedCrossRef Young T, Peppard P, Palta M et al (1997) Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 157:1746–1752PubMedCrossRef
20.
go back to reference Kasai T, Narui K, Dohi T et al (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690–696PubMedCrossRef Kasai T, Narui K, Dohi T et al (2008) Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 133:690–696PubMedCrossRef
21.
go back to reference Kannel W, Hjortland M, Castelli W (1974) Role of diabetes in congestive heart failure. Am J Cardiol 34:29–34PubMedCrossRef Kannel W, Hjortland M, Castelli W (1974) Role of diabetes in congestive heart failure. Am J Cardiol 34:29–34PubMedCrossRef
22.
go back to reference Polikar R, Burger AG, Scherrer U, Nicod P (1993) The thyroid and the heart. Circulation 87:1435–1441PubMed Polikar R, Burger AG, Scherrer U, Nicod P (1993) The thyroid and the heart. Circulation 87:1435–1441PubMed
23.
go back to reference Cavallo A, Joseph CJ, Casta A (1984) Cardiac complications in juvenile hyperthyroidism. Am J Dis Child 138:479PubMed Cavallo A, Joseph CJ, Casta A (1984) Cardiac complications in juvenile hyperthyroidism. Am J Dis Child 138:479PubMed
24.
go back to reference Mac Kerrow SD, Osborn LA, Levy H, Eaton RP, Economou P (1992) Myxedema-associated cardiogenic shock treated with intravenous triiodothyronine. Ann Intern Med 117:1014–1015 Mac Kerrow SD, Osborn LA, Levy H, Eaton RP, Economou P (1992) Myxedema-associated cardiogenic shock treated with intravenous triiodothyronine. Ann Intern Med 117:1014–1015
25.
go back to reference CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 316:1429–1435CrossRef CONSENSUS Trial Study Group (1987) Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 316:1429–1435CrossRef
26.
go back to reference SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325:293–302CrossRef SOLVD Investigators (1991) Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 325:293–302CrossRef
27.
go back to reference Pfeffer MA, Braunwald E, Moyé LA et al (1992) Effect of captopril on mortality and morbidity in patients with left-ventricular dysfunction after myocardial infarction -results of the Survival and Ventricular Enlargement Trial. N Engl J Med 327:669–677PubMedCrossRef Pfeffer MA, Braunwald E, Moyé LA et al (1992) Effect of captopril on mortality and morbidity in patients with left-ventricular dysfunction after myocardial infarction -results of the Survival and Ventricular Enlargement Trial. N Engl J Med 327:669–677PubMedCrossRef
28.
go back to reference Acute Infarction Ramipril Efficacy (AIRE) Study investigators (1993) Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342:821–828 Acute Infarction Ramipril Efficacy (AIRE) Study investigators (1993) Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 342:821–828
29.
go back to reference Kober L, Torp-Pedersen C, Carlsen JE et al, for the Trandolapril Cardiac Evaluation (TRACE) study group (1995) A clinical-trial of the angiotensinconverting enzyme inhibitor trandolapril in patients with left-ventricular dysfunction after myocardial infarction. N Engl J Med 333:1670–1676 Kober L, Torp-Pedersen C, Carlsen JE et al, for the Trandolapril Cardiac Evaluation (TRACE) study group (1995) A clinical-trial of the angiotensinconverting enzyme inhibitor trandolapril in patients with left-ventricular dysfunction after myocardial infarction. N Engl J Med 333:1670–1676
30.
go back to reference Komukai K, Yagi H, Ogawa T et al (2008) Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction. Circ J 72:2004–2008PubMedCrossRef Komukai K, Yagi H, Ogawa T et al (2008) Inhibition of the renin-angiotensin system prevents re-hospitalization of heart failure patients with preserved ejection fraction. Circ J 72:2004–2008PubMedCrossRef
31.
go back to reference Munzel T, Keaney JF Jr (2001) Are ACE inhibitors the “magic bullet” against oxidative stress? Circulation 104:1571–1574PubMedCrossRef Munzel T, Keaney JF Jr (2001) Are ACE inhibitors the “magic bullet” against oxidative stress? Circulation 104:1571–1574PubMedCrossRef
32.
go back to reference Khalil ME, Basher AW, Brown EJ Jr, Alhaddad IA (2001) A remarkable medical story: benefits of angiotensin-converting enzyme inhibitors in cardiac patients. J Am Coll Cardiol 37:1757–1764PubMedCrossRef Khalil ME, Basher AW, Brown EJ Jr, Alhaddad IA (2001) A remarkable medical story: benefits of angiotensin-converting enzyme inhibitors in cardiac patients. J Am Coll Cardiol 37:1757–1764PubMedCrossRef
33.
go back to reference Garg R, Yusuf S (1995) Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 273:1450–1456PubMedCrossRef Garg R, Yusuf S (1995) Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. JAMA 273:1450–1456PubMedCrossRef
34.
go back to reference Sueta C, Massing MW, Simpson RJ (1999) Undertreatment of older patients with congestive heart failure. J Card Fail 5:66CrossRef Sueta C, Massing MW, Simpson RJ (1999) Undertreatment of older patients with congestive heart failure. J Card Fail 5:66CrossRef
35.
go back to reference McDonald K, Ledwidge M, Cahill J et al (2001) Elimination of early rehospitalization in a randomized, controlled trial of multidisciplinary care in a high-risk, elderly heart failure population: the potential contributions of specialist care, clinical stability and optimal angiotensin-converting enzyme inhibitor dose at discharge. Eur J Heart Fail 3(2):209–215PubMedCrossRef McDonald K, Ledwidge M, Cahill J et al (2001) Elimination of early rehospitalization in a randomized, controlled trial of multidisciplinary care in a high-risk, elderly heart failure population: the potential contributions of specialist care, clinical stability and optimal angiotensin-converting enzyme inhibitor dose at discharge. Eur J Heart Fail 3(2):209–215PubMedCrossRef
36.
go back to reference Consensus Recommedations for the Management of Chronic Heart Failure (1999) Am J Cardiol 83: 2a–38a Consensus Recommedations for the Management of Chronic Heart Failure (1999) Am J Cardiol 83: 2a–38a
37.
go back to reference Bown Luzier A, Forrest A, Adelman M et al (1998) Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure. Am J Cardiol 82:465–469CrossRef Bown Luzier A, Forrest A, Adelman M et al (1998) Impact of angiotensin-converting enzyme inhibitor underdosing on rehospitalization rates in congestive heart failure. Am J Cardiol 82:465–469CrossRef
38.
go back to reference Packer M, Poole-Wilson PA, Armstrong PW et al (1999) Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. Circulation 100:1–7 Packer M, Poole-Wilson PA, Armstrong PW et al (1999) Comparative effects of low and high doses of the angiotensin-converting enzyme inhibitor, lisinopril, on morbidity and mortality in chronic heart failure. Circulation 100:1–7
39.
go back to reference Pitt B, Zannad F, Remme WJ et al, for the Randomized Aldactone Evaluation Study Investigators (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–17 Pitt B, Zannad F, Remme WJ et al, for the Randomized Aldactone Evaluation Study Investigators (1999) The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 341:709–17
40.
go back to reference Jacob MS, Tang WH (2011) Aldosterone-receptor antagonists in heart failure: insights after EMPHASIS-HF. Curr Heart Fail Rep 8(1):7–13PubMedCrossRef Jacob MS, Tang WH (2011) Aldosterone-receptor antagonists in heart failure: insights after EMPHASIS-HF. Curr Heart Fail Rep 8(1):7–13PubMedCrossRef
41.
go back to reference CIBIS-II Investigators Committee (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 353:9–13CrossRef CIBIS-II Investigators Committee (1999) The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial. Lancet 353:9–13CrossRef
42.
go back to reference Study Group MERIT-HF (1999) Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERITHF). Lancet 353:2001–2007CrossRef Study Group MERIT-HF (1999) Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERITHF). Lancet 353:2001–2007CrossRef
43.
go back to reference Packer M, Coats AJ, Fowler MB et al (2001) Carvedilol prospective randomized cumulative survival study group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651–1658PubMedCrossRef Packer M, Coats AJ, Fowler MB et al (2001) Carvedilol prospective randomized cumulative survival study group. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med 344:1651–1658PubMedCrossRef
44.
go back to reference Packer M, Fowler MB, Roecker EB et al (2002) Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106(17):2194–2199 Packer M, Fowler MB, Roecker EB et al (2002) Carvedilol Prospective Randomized Cumulative Survival (COPERNICUS) Study Group. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation 106(17):2194–2199
45.
go back to reference Hernandez AF, Hammill BG, O’Connor CM, Schulman KA, Curtis LH, Fonarow GC (2009) Clinical effectiveness of beta-blockers in heart failure. Findings from the OPTIMIZE-HF Registry. J Am Coll Cardiol 53:184–192PubMedCrossRef Hernandez AF, Hammill BG, O’Connor CM, Schulman KA, Curtis LH, Fonarow GC (2009) Clinical effectiveness of beta-blockers in heart failure. Findings from the OPTIMIZE-HF Registry. J Am Coll Cardiol 53:184–192PubMedCrossRef
46.
go back to reference Group TheDigitalisInvestigation (1997) The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336:525–533CrossRef Group TheDigitalisInvestigation (1997) The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336:525–533CrossRef
47.
go back to reference Taylor AL, Ziesche S, Yancy C et al, for the African-American Heart Failure Trial Investigators (2004) Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 351:2049–2057 Taylor AL, Ziesche S, Yancy C et al, for the African-American Heart Failure Trial Investigators (2004) Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med 351:2049–2057
48.
go back to reference Hamner JB, Ellison KJ (2005) Predictors of hospital readmission after discharge in patients with congestive heart failure. Heart Lung 34:231–239PubMedCrossRef Hamner JB, Ellison KJ (2005) Predictors of hospital readmission after discharge in patients with congestive heart failure. Heart Lung 34:231–239PubMedCrossRef
49.
go back to reference McAlister FA, Stewart S, Ferrua S, McMurray JJJV (2004) Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials. J Am Coll Cardiol 44:810–819PubMed McAlister FA, Stewart S, Ferrua S, McMurray JJJV (2004) Multidisciplinary strategies for the management of heart failure patients at high risk for admission: a systematic review of randomized trials. J Am Coll Cardiol 44:810–819PubMed
50.
go back to reference Cleland JGF, Daubert JC, Erdmann E et al, for the Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352:1539–1549 Cleland JGF, Daubert JC, Erdmann E et al, for the Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators (2005) The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 352:1539–1549
51.
go back to reference Tang ASL, Wells GA, Talaiic M et al, for the Resynchronization–Defibrillation for Ambulatory Heart Failure Trial (RAFT) Investigators (2010) Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure. N Engl J Med 363:2385-2395 Tang ASL, Wells GA, Talaiic M et al, for the Resynchronization–Defibrillation for Ambulatory Heart Failure Trial (RAFT) Investigators (2010) Cardiac-Resynchronization Therapy for Mild-to-Moderate Heart Failure. N Engl J Med 363:2385-2395
52.
go back to reference Moss AJ, Hall WJ, Cannom DS et al, for the MADIT-CRT Trial Investigators (2009) Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events. N Engl J Med 361(14):1329–1338 Moss AJ, Hall WJ, Cannom DS et al, for the MADIT-CRT Trial Investigators (2009) Cardiac-Resynchronization Therapy for the Prevention of Heart-Failure Events. N Engl J Med 361(14):1329–1338
53.
go back to reference Fonarow GC, Yancy CW, Albert NM et al (2008) Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF. Circ Heart Fail 1:98–106PubMedCrossRef Fonarow GC, Yancy CW, Albert NM et al (2008) Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF. Circ Heart Fail 1:98–106PubMedCrossRef
54.
go back to reference Bourge RC, Abraham WT, Adamson PB et al (2008) Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure (The COMPASS-HF Study). J Am Coll Cardiol 51:1073–1079PubMedCrossRef Bourge RC, Abraham WT, Adamson PB et al (2008) Randomized controlled trial of an implantable continuous hemodynamic monitor in patients with advanced heart failure (The COMPASS-HF Study). J Am Coll Cardiol 51:1073–1079PubMedCrossRef
55.
go back to reference Ritzema J, Troughton R, Melton I et al (2010) Physician-directed patient self-management of left-atrial pressure in advanced chronic heart failure. Circulation 116:2952–2959CrossRef Ritzema J, Troughton R, Melton I et al (2010) Physician-directed patient self-management of left-atrial pressure in advanced chronic heart failure. Circulation 116:2952–2959CrossRef
56.
go back to reference Abraham WT, Adamson PB (2010) Primary results of the CardioMEMS heart sensor allows monitoring of pressure to improve outcomes in NYHA class III heart-failure patients (champion) trial. Heart Failure Congress 2010 May 29-June 1, 2010; Berlin, Germany Abraham WT, Adamson PB (2010) Primary results of the CardioMEMS heart sensor allows monitoring of pressure to improve outcomes in NYHA class III heart-failure patients (champion) trial. Heart Failure Congress 2010 May 29-June 1, 2010; Berlin, Germany
57.
go back to reference Krumholtz HM, Parent EM, Tu N et al (1997) Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med 157:99–104CrossRef Krumholtz HM, Parent EM, Tu N et al (1997) Readmission after hospitalization for congestive heart failure among Medicare beneficiaries. Arch Intern Med 157:99–104CrossRef
58.
go back to reference Krumholz HM, Chen YT, Wang Y et al (2000) Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J 139(1, pt 1):72–77 Krumholz HM, Chen YT, Wang Y et al (2000) Predictors of readmission among elderly survivors of admission with heart failure. Am Heart J 139(1, pt 1):72–77
59.
go back to reference Komukai K, Ogawa T, Yagi H et al (2008) Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure. Circ J 72:1152–1157PubMedCrossRef Komukai K, Ogawa T, Yagi H et al (2008) Decreased renal function as an independent predictor of re-hospitalization for congestive heart failure. Circ J 72:1152–1157PubMedCrossRef
60.
go back to reference Tsuchihashi M, Tsutsui H, Kodama K et al (2001) Medical and socioenvironmental predictors of hospital readmission in patients with congestive heart failure. Am Heart J 142:e7PubMedCrossRef Tsuchihashi M, Tsutsui H, Kodama K et al (2001) Medical and socioenvironmental predictors of hospital readmission in patients with congestive heart failure. Am Heart J 142:e7PubMedCrossRef
61.
go back to reference Dokainish H, Zoghbi WA, Lakkis NM et al (2005) Incremental predictive power of B-type natriuretic peptide and tissue doppler echocardiography in the prognosis of patients with congestive heart failure. J Am Coll Cardiol 45:1223–1226PubMedCrossRef Dokainish H, Zoghbi WA, Lakkis NM et al (2005) Incremental predictive power of B-type natriuretic peptide and tissue doppler echocardiography in the prognosis of patients with congestive heart failure. J Am Coll Cardiol 45:1223–1226PubMedCrossRef
62.
go back to reference Alahdab MT, Mansour IN, Napan S, Stamos T (2009) Six minute walk test predicts long-term all-cause mortality and heart failure re-hospitalization in African-American patients hospitalized with acute decompensated heart failure. J Cardiac Fail 15:130–135CrossRef Alahdab MT, Mansour IN, Napan S, Stamos T (2009) Six minute walk test predicts long-term all-cause mortality and heart failure re-hospitalization in African-American patients hospitalized with acute decompensated heart failure. J Cardiac Fail 15:130–135CrossRef
63.
go back to reference Damman K, Navis G, Voors AA et al (2007) Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail 13:599–608PubMedCrossRef Damman K, Navis G, Voors AA et al (2007) Worsening renal function and prognosis in heart failure: systematic review and meta-analysis. J Card Fail 13:599–608PubMedCrossRef
64.
go back to reference Smith GL, Lichtman JH, Bracken MB et al (2006) Renal impairment and outcomes in heart failure: systematic review and meta-analysis. J Am Coll Cardiol 47:1987–1996PubMedCrossRef Smith GL, Lichtman JH, Bracken MB et al (2006) Renal impairment and outcomes in heart failure: systematic review and meta-analysis. J Am Coll Cardiol 47:1987–1996PubMedCrossRef
65.
go back to reference McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW (2004) Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. Circulation 109:1004–1009PubMedCrossRef McAlister FA, Ezekowitz J, Tonelli M, Armstrong PW (2004) Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study. Circulation 109:1004–1009PubMedCrossRef
66.
go back to reference Goldenberg I, Moss AJ, Hall WJ et al (2006) Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II. Circulation 113:2810–2817PubMedCrossRef Goldenberg I, Moss AJ, Hall WJ et al (2006) Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II. Circulation 113:2810–2817PubMedCrossRef
67.
go back to reference Whellan DJ, Ousdigian KT, Al-Khatib SM et al (2010) Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from partners HF study. J Am Coll Cardiol 55:1803–1810PubMedCrossRef Whellan DJ, Ousdigian KT, Al-Khatib SM et al (2010) Combined heart failure device diagnostics identify patients at higher risk of subsequent heart failure hospitalizations: results from partners HF study. J Am Coll Cardiol 55:1803–1810PubMedCrossRef
68.
go back to reference Klein L, Massic BM, Leimberger JD et al, for the OPTIME-CHF Investigators (2008) Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure (OPTIME-CHF). Circulation 1:25–33 Klein L, Massic BM, Leimberger JD et al, for the OPTIME-CHF Investigators (2008) Admission or changes in renal function during hospitalization for worsening heart failure predict postdischarge survival: results from the outcomes of a prospective trial of intravenous milrinone for exacerbations of chronic heart failure (OPTIME-CHF). Circulation 1:25–33
69.
go back to reference Filippatos G, Rossi J, Lloyd-Jones DM et al (2007) Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: insights from the acute and chronic therapeutic impact of a vasopressin antagonist in chronic heart failure (ACTIV in CHF) study. J Card Fail 13:360–364PubMedCrossRef Filippatos G, Rossi J, Lloyd-Jones DM et al (2007) Prognostic value of blood urea nitrogen in patients hospitalized with worsening heart failure: insights from the acute and chronic therapeutic impact of a vasopressin antagonist in chronic heart failure (ACTIV in CHF) study. J Card Fail 13:360–364PubMedCrossRef
70.
go back to reference Gheorghiade M, Rossi JS, Cotts W et al (2007) Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial. Arch Intern Med 167(18):1998–2005PubMedCrossRef Gheorghiade M, Rossi JS, Cotts W et al (2007) Characterization and prognostic value of persistent hyponatremia in patients with severe heart failure in the ESCAPE trial. Arch Intern Med 167(18):1998–2005PubMedCrossRef
71.
go back to reference Felker GM, Gattis WA, Leimberger JD et al (2003) Usefulness of Anemia as a predictor of death and re-hospitalization in patients with decompensated heart failure. Am J Cardiol 92:625–628PubMedCrossRef Felker GM, Gattis WA, Leimberger JD et al (2003) Usefulness of Anemia as a predictor of death and re-hospitalization in patients with decompensated heart failure. Am J Cardiol 92:625–628PubMedCrossRef
72.
go back to reference Dunlay SM, Gerber Y, Weston SA, Killian JM, Redfield MM, Roger VL (2009) Prognostic value of biomarkers in heart failure: application of novel methods in the community. Circ Heart Fail 2:393–400PubMedCrossRef Dunlay SM, Gerber Y, Weston SA, Killian JM, Redfield MM, Roger VL (2009) Prognostic value of biomarkers in heart failure: application of novel methods in the community. Circ Heart Fail 2:393–400PubMedCrossRef
73.
go back to reference Manzano-Fernandez S, Boronat-Garcia M, Albaladejo-Otón MD et al (2009) Complementary prognostic value of cystatin C, N-Terminal Pro-B-type natriuretic peptide and cardiac troponin T in patients with acute heart failure. Am J Cardiol 103:1753–1759PubMedCrossRef Manzano-Fernandez S, Boronat-Garcia M, Albaladejo-Otón MD et al (2009) Complementary prognostic value of cystatin C, N-Terminal Pro-B-type natriuretic peptide and cardiac troponin T in patients with acute heart failure. Am J Cardiol 103:1753–1759PubMedCrossRef
74.
go back to reference Goonewardena SN, Gemignani A, Ronan A et al (2008) Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-Terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure. JACC Cardiovasc Imaging 1(5):595–601PubMedCrossRef Goonewardena SN, Gemignani A, Ronan A et al (2008) Comparison of hand-carried ultrasound assessment of the inferior vena cava and N-Terminal pro-brain natriuretic peptide for predicting readmission after hospitalization for acute decompensated heart failure. JACC Cardiovasc Imaging 1(5):595–601PubMedCrossRef
75.
go back to reference Niizeki T, Takeishi Y, Kitahara T et al (2009) Combination of conventional biomarkers for risk stratification in chronic heart failure. J Cardiol 53:179–187PubMedCrossRef Niizeki T, Takeishi Y, Kitahara T et al (2009) Combination of conventional biomarkers for risk stratification in chronic heart failure. J Cardiol 53:179–187PubMedCrossRef
76.
go back to reference Gackowski D, Isnard R, Golmard JL et al (2004) Comparison of echocardiography and plasma B-type natriuretic peptide for monitoring the response to treatment in acute heart failure. Eur Heart J 25:1788–1796PubMedCrossRef Gackowski D, Isnard R, Golmard JL et al (2004) Comparison of echocardiography and plasma B-type natriuretic peptide for monitoring the response to treatment in acute heart failure. Eur Heart J 25:1788–1796PubMedCrossRef
77.
go back to reference Cheng V, Kazanagra R, Garcia A et al (2001) A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 37:386–391PubMedCrossRef Cheng V, Kazanagra R, Garcia A et al (2001) A rapid bedside test for B-type peptide predicts treatment outcomes in patients admitted for decompensated heart failure: a pilot study. J Am Coll Cardiol 37:386–391PubMedCrossRef
78.
go back to reference Logeart D, Thabut G, Jourdain P et al (2004) Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure. J Am Coll Cardiol 43:635–641PubMedCrossRef Logeart D, Thabut G, Jourdain P et al (2004) Predischarge B-type natriuretic peptide assay for identifying patients at high risk of re-admission after decompensated heart failure. J Am Coll Cardiol 43:635–641PubMedCrossRef
79.
go back to reference Jiang W, Alexander J, Christopher E et al (2001) Relationship to increased risk of mortality and re-hospitalization in patients with congestive heart failure. Arch Intern Med 161:1849–1856PubMedCrossRef Jiang W, Alexander J, Christopher E et al (2001) Relationship to increased risk of mortality and re-hospitalization in patients with congestive heart failure. Arch Intern Med 161:1849–1856PubMedCrossRef
80.
go back to reference Albert NM, Fonarow GC, Abraham WT et al (2009) Depression and clinical outcomes in heart failure: an OPTIMIZE-HF analysis. Am J Med 122:366–373PubMedCrossRef Albert NM, Fonarow GC, Abraham WT et al (2009) Depression and clinical outcomes in heart failure: an OPTIMIZE-HF analysis. Am J Med 122:366–373PubMedCrossRef
81.
go back to reference Krumholz HM, Butler J, Miller J et al (1998) Prognostic importance of emotional support for elderly patients hospitalized with heart failure. Circulation 80:428–429 Krumholz HM, Butler J, Miller J et al (1998) Prognostic importance of emotional support for elderly patients hospitalized with heart failure. Circulation 80:428–429
82.
go back to reference Chin MH, Goldman L (1997) Correlates of early hospital readmission or death in patients with congestive heart failure. Am J Cardiol 79:1640–1644PubMedCrossRef Chin MH, Goldman L (1997) Correlates of early hospital readmission or death in patients with congestive heart failure. Am J Cardiol 79:1640–1644PubMedCrossRef
83.
go back to reference Alexander M, Grumbach K, Remy L, Rowell R, Massie BM (1999) Congestive heart failure hospitalizations and survival in California: patterns according to race/ethnicity. Am Heart J 137:919–927PubMedCrossRef Alexander M, Grumbach K, Remy L, Rowell R, Massie BM (1999) Congestive heart failure hospitalizations and survival in California: patterns according to race/ethnicity. Am Heart J 137:919–927PubMedCrossRef
84.
go back to reference Ambardekar AV, Fonarow GC, Hernandez AF, Pan W, Yancy CW, Krantz MJ; Get With The Guidelines Steering Committee and Hospitals (2009) Characteristics and in-hospital outcomes for nonadherent patients with heart failure: findings from get with the guidelines-heart failure (GWTG-HF). Am Heart J 158(4):644–652 Ambardekar AV, Fonarow GC, Hernandez AF, Pan W, Yancy CW, Krantz MJ; Get With The Guidelines Steering Committee and Hospitals (2009) Characteristics and in-hospital outcomes for nonadherent patients with heart failure: findings from get with the guidelines-heart failure (GWTG-HF). Am Heart J 158(4):644–652
85.
go back to reference Heiat A, Gross CP, Krumholz HM (2002) Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 162:682–688CrossRef Heiat A, Gross CP, Krumholz HM (2002) Representation of the elderly, women, and minorities in heart failure clinical trials. Arch Intern Med 162:682–688CrossRef
86.
go back to reference Tsuyuki RT, McKelvie RS, Arnold MO et al (2001) Acute precipitants of congestive heart failure exacerbations. Arch Intern Med 161:2337–2342PubMedCrossRef Tsuyuki RT, McKelvie RS, Arnold MO et al (2001) Acute precipitants of congestive heart failure exacerbations. Arch Intern Med 161:2337–2342PubMedCrossRef
87.
go back to reference Granger BB, Swedbery K, Ekman I et al, CHARM investigators (2005) Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double blind, randomized, controlled clinical trial. Lancet 366:2005–2011 Granger BB, Swedbery K, Ekman I et al, CHARM investigators (2005) Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: double blind, randomized, controlled clinical trial. Lancet 366:2005–2011
88.
go back to reference Ghali JK, Kadakia S, Cooper R, Ferlinz J (1988) Precipitating factors leading to decompensation in heart failure: traits among blacks. Arch Intern Med 148:2013–2016PubMedCrossRef Ghali JK, Kadakia S, Cooper R, Ferlinz J (1988) Precipitating factors leading to decompensation in heart failure: traits among blacks. Arch Intern Med 148:2013–2016PubMedCrossRef
89.
go back to reference Mockler M, O’Loughlin C, Murphy N et al (2009) Causes and consequences of nonpersistence with heart failure medication. Am J Cardiol 103:834–838PubMedCrossRef Mockler M, O’Loughlin C, Murphy N et al (2009) Causes and consequences of nonpersistence with heart failure medication. Am J Cardiol 103:834–838PubMedCrossRef
90.
go back to reference Fonarow GC, Abraham WT, Albert NM et al, for the OPTIMIZE-HF Investigators and Hospitals (2008) Factors identified as precipitating hospital admission for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med 168:847–854 Fonarow GC, Abraham WT, Albert NM et al, for the OPTIMIZE-HF Investigators and Hospitals (2008) Factors identified as precipitating hospital admission for heart failure and clinical outcomes: findings from OPTIMIZE-HF. Arch Intern Med 168:847–854
91.
go back to reference Ekman I, Norberg A, Lundman B (2000) An intervention aimed at reducing uncertainty in elderly patients with chronic heart failure. Int J Hum Caring 4(1):7–13 Ekman I, Norberg A, Lundman B (2000) An intervention aimed at reducing uncertainty in elderly patients with chronic heart failure. Int J Hum Caring 4(1):7–13
92.
go back to reference Koelling TM, Johnson ML, Cody RJ, Aaronson KD (2005) Discharge education improves clinical outcomes in patients with chronic heart failure. Circulation 111(2):179–185PubMedCrossRef Koelling TM, Johnson ML, Cody RJ, Aaronson KD (2005) Discharge education improves clinical outcomes in patients with chronic heart failure. Circulation 111(2):179–185PubMedCrossRef
93.
go back to reference Ducharme A, Doyon O, White M, Rouleau JL, Brophy JM (2005) Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial. CMAJ 173(1):40–45PubMedCrossRef Ducharme A, Doyon O, White M, Rouleau JL, Brophy JM (2005) Impact of care at a multidisciplinary congestive heart failure clinic: a randomized trial. CMAJ 173(1):40–45PubMedCrossRef
94.
go back to reference Phillips CO, Wright SM, Kern DE, Singa RM, Shepperd S, Rubin HR (2004) Comprehensive discharge planning with postdischarge support for older patients with congestive heart failure. JAMA 291:1358–1367PubMedCrossRef Phillips CO, Wright SM, Kern DE, Singa RM, Shepperd S, Rubin HR (2004) Comprehensive discharge planning with postdischarge support for older patients with congestive heart failure. JAMA 291:1358–1367PubMedCrossRef
95.
go back to reference Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl JMed 333(18):1190–1195CrossRef Rich MW, Beckham V, Wittenberg C, Leven CL, Freedland KE, Carney RM (1995) A multidisciplinary intervention to prevent the readmission of elderly patients with congestive heart failure. N Engl JMed 333(18):1190–1195CrossRef
96.
go back to reference Krumholz HM, Amatruda J, Smith GL et al (2002) Randomized trial of an education and support intervention to prevent readmission of patients with heart failure. J Am Coll Cardiol 39(1):83–89PubMedCrossRef Krumholz HM, Amatruda J, Smith GL et al (2002) Randomized trial of an education and support intervention to prevent readmission of patients with heart failure. J Am Coll Cardiol 39(1):83–89PubMedCrossRef
97.
go back to reference GESICA Investigators (2005) Randomised trial of telephone intervention in chronic heart failure: DIAL trial. BMJ 331(7514):425CrossRef GESICA Investigators (2005) Randomised trial of telephone intervention in chronic heart failure: DIAL trial. BMJ 331(7514):425CrossRef
98.
go back to reference Cline C, Israelsson B, Willenheimer R, Broms K, Erhardt L (1998) A cost effective management programme for heart failure reduces hospitalisation. Heart 80:442–446PubMed Cline C, Israelsson B, Willenheimer R, Broms K, Erhardt L (1998) A cost effective management programme for heart failure reduces hospitalisation. Heart 80:442–446PubMed
99.
go back to reference Stewart S, Pearson S, Horowitz JD (1998) Effects of a home-based intervention among congestive heart failure patients discharged from acute hospital care. Arch Intern Med 158:1067–1072PubMedCrossRef Stewart S, Pearson S, Horowitz JD (1998) Effects of a home-based intervention among congestive heart failure patients discharged from acute hospital care. Arch Intern Med 158:1067–1072PubMedCrossRef
100.
go back to reference Doughty RN, Wright SP, Walsh HJ et al (2002) Randomised, controlled trial of integrated heart failure management: the auckland heart failure management study. Eur Heart J 23:139–146PubMedCrossRef Doughty RN, Wright SP, Walsh HJ et al (2002) Randomised, controlled trial of integrated heart failure management: the auckland heart failure management study. Eur Heart J 23:139–146PubMedCrossRef
101.
go back to reference Blue L, Lang E, McMurray JJV et al (2001) Randomised controlled of specialist nurse intervention in heart failure. BMJ 323:715–718PubMedCrossRef Blue L, Lang E, McMurray JJV et al (2001) Randomised controlled of specialist nurse intervention in heart failure. BMJ 323:715–718PubMedCrossRef
102.
go back to reference Naylor MD, Brooten D, Campbell R et al (1999) Comprehensive discharge planning and home follow-up of hospitalized elders: a randomized clinical trial. JAMA 281:613–620PubMedCrossRef Naylor MD, Brooten D, Campbell R et al (1999) Comprehensive discharge planning and home follow-up of hospitalized elders: a randomized clinical trial. JAMA 281:613–620PubMedCrossRef
103.
go back to reference Stewart S, Horowitz JD (2002) Home-based intervention in congestive heart failure; long-term implications in readmission and survival. Circulation 105:2861–2866PubMedCrossRef Stewart S, Horowitz JD (2002) Home-based intervention in congestive heart failure; long-term implications in readmission and survival. Circulation 105:2861–2866PubMedCrossRef
104.
go back to reference Ross JS, Chen J, Lin Z et al (2010) Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail 1:97–103CrossRef Ross JS, Chen J, Lin Z et al (2010) Recent national trends in readmission rates after heart failure hospitalization. Circ Heart Fail 1:97–103CrossRef
Metadata
Title
The dilemma, causes and approaches to avoid recurrent hospital readmissions for patients with chronic heart failure
Authors
Melody Zaya
Anita Phan
Ernst R. Schwarz
Publication date
01-05-2012
Publisher
Springer US
Published in
Heart Failure Reviews / Issue 3/2012
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-011-9256-0

Other articles of this Issue 3/2012

Heart Failure Reviews 3/2012 Go to the issue