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European Journal of Epidemiology
Published in: European Journal of Epidemiology 2/2020

Open Access 01-02-2020 | COHORT PROFILE

Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study

Authors: Willemijn D. B. Warmink-Perdijk, Lilian L. Peters, Ettje F. Tigchelaar, Jackie A. M. Dekens, Soesma A. Jankipersadsing, Alexandra Zhernakova, Willem J. R. Bossers, Jan Sikkema, Ank de Jonge, Sijmen A. Reijneveld, Henkjan J. Verkade, Gerard H. Koppelman, Cisca Wijmenga, Folkert Kuipers, Sicco A. Scherjon

Published in: European Journal of Epidemiology | Issue 2/2020

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Abstract

Epidemiological research has shown there to be a strong relationship between preconceptional, prenatal, birth and early-life factors and lifelong health. The Lifelines NEXT is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease in a four-generation design. It is embedded within the Lifelines cohort study, a prospective three-generation population-based cohort study recording the health and health-related aspects of 167,729 individuals living in Northern Netherlands. In Lifelines NEXT we aim to include 1500 pregnant Lifelines participants and intensively follow them, their partners and their children until at least 1 year after birth. Longer-term follow-up of physical and psychological health will then be embedded following Lifelines procedures. During the Lifelines NEXT study period biomaterials—including maternal and neonatal (cord) blood, placental tissue, feces, breast milk, nasal swabs and urine—will be collected from the mother and child at 10 time points. We will also collect data on medical, social, lifestyle and environmental factors via questionnaires at 14 different time points and continuous data via connected devices. The extensive collection of different (bio)materials from mother and child during pregnancy and afterwards will provide the means to relate environmental factors including maternal and neonatal microbiome composition) to (epi)genetics, health and developmental outcomes. The nesting of the study within Lifelines enables us to include preconceptional transgenerational data and can be used to identify other extended families within the cohort.
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Metadata
Title
Lifelines NEXT: a prospective birth cohort adding the next generation to the three-generation Lifelines cohort study
Authors
Willemijn D. B. Warmink-Perdijk
Lilian L. Peters
Ettje F. Tigchelaar
Jackie A. M. Dekens
Soesma A. Jankipersadsing
Alexandra Zhernakova
Willem J. R. Bossers
Jan Sikkema
Ank de Jonge
Sijmen A. Reijneveld
Henkjan J. Verkade
Gerard H. Koppelman
Cisca Wijmenga
Folkert Kuipers
Sicco A. Scherjon
Publication date
01-02-2020
Publisher
Springer Netherlands
Published in
European Journal of Epidemiology / Issue 2/2020
Print ISSN: 0393-2990
Electronic ISSN: 1573-7284
DOI
https://doi.org/10.1007/s10654-020-00614-7

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