Published in:
01-08-2011 | PRECLINICAL STUDIES
Cribrostatin 6 induces death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism
Authors:
Mirth T. Hoyt, Rahul Palchaudhuri, Paul J. Hergenrother
Published in:
Investigational New Drugs
|
Issue 4/2011
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Summary
Cribrostatin 6 is a quinone-containing natural product that induces the death of cancer cell lines in culture, and its mechanism of action and scope of activity are unknown. Here we show that cribrostatin 6 has broad anticancer activity, potently inducing apoptotic cell death that is not preceded by any defined cell cycle arrest. Consistent with this data, we find that cribrostatin 6 treated cells have large amounts of reactive oxygen species (ROS) and, based on transcript profiling experiments and other data, this ROS generation is likely the primary mechanism by which cribrostatin 6 induces apoptosis. Given the success of certain ROS producers as anticancer agents, cribrostatin 6 has potential as a novel chemotherapeutic agent.