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01-04-2009 | PRECLINICAL STUDIES

Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth

Authors: Masaharu Hazawa, Koji Wada, Kenji Takahashi, Takao Mori, Norio Kawahara, Ikuo Kashiwakura

Published in: Investigational New Drugs | Issue 2/2009

Summary

Little information has so far been reported regarding the antiproliferative properties of Aconitum alkaloids against human tumor cells despite of their intense toxicities. In the present study, the antitumor properties and radiation sensitizing effects were investigated by various types of novel derivatives prepared from Aconitum alkaloids. The antitumor properties were investigated against human tumor cell lines, A172, A549, HeLa and Raji, respectively, by a cell growth, a clonogenic assay, cell cycle distribution, cell cycle related molecules and γH2AX expression. The novel compounds derived from C₂₀-diterupenoid alkaloids showed a significantly suppressive effect in all cell lines. In contrast, natural C₁₉-norditerpenoid alkaloids and their derivatives showed either no effect or only a slight effect. One of the compounds also showed radiosensitizing properties on A549 cells. These effects are not related to either the cell cycle distribution, the enhancement of apoptosis or the γH2AX expression. Novel derivatives prepared from Aconitum alkaloids, not but natural alkaloids, clearly showed anti-proliferative activity in human tumor cell lines.

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Title: Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth
Authors: Masaharu Hazawa
Koji Wada
Kenji Takahashi
Takao Mori
Norio Kawahara
Ikuo Kashiwakura
Publication date: 01-04-2009
Publisher: Springer US
Published in: Investigational New Drugs / Issue 2/2009
Print ISSN: 0167-6997
Electronic ISSN: 1573-0646
DOI: https://doi.org/10.1007/s10637-008-9141-4

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