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Open Access 01-06-2018 | ISCEV Standards

ISCEV extended protocol for the photopic On–Off ERG

Authors: Maja Sustar, Graham E. Holder, Jan Kremers, Claire S. Barnes, Bo Lei, Naheed W. Khan, Anthony G. Robson

Published in: Documenta Ophthalmologica | Issue 3/2018

Abstract

The International Society for Clinical Electrophysiology of Vision (ISCEV) standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG standard, namely the photopic On–Off ERG, and outlines common clinical applications. A light stimulus duration of 150–200 ms is used in the presence of a rod-suppressing background to elicit cone-driven On- and Off-system ERG components. The On-response occurs after the stimulus onset and has a negative a-wave and positive b-wave. The Off d-wave is a positive component evoked by stimulus offset. Common diagnoses that may benefit from additional photopic On–Off ERG testing include retinal dystrophies and retinal disorders that cause dysfunction at a level that is post-phototransduction or post-receptoral. On–Off ERGs assess the relative involvement of On- and Off-systems and may be of use in the diagnosis of disorders such as complete and incomplete congenital stationary night blindness (complete and incomplete CSNB), melanoma-associated retinopathy, and some forms of autoimmune retinopathy. The photopic On–Off ERGs may also be useful in X-linked retinoschisis, Batten disease, Duchenne muscular dystrophy, spinocerebellar degeneration, quinine toxicity, and other retinal disorders.

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Title: ISCEV extended protocol for the photopic On–Off ERG
Authors: Maja Sustar
Graham E. Holder
Jan Kremers
Claire S. Barnes
Bo Lei
Naheed W. Khan
Anthony G. Robson
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Documenta Ophthalmologica / Issue 3/2018
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-018-9645-y

At a glance: The STEP trials

Springer Medicine

ISCEV extended protocol for the photopic On–Off ERG

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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