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Documenta Ophthalmologica

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Open Access 01-08-2017 | Original Research Article

Wavelet decomposition analysis in the two-flash multifocal ERG in early glaucoma: a comparison to ganglion cell analysis and visual field

Authors: Livia M Brandao, Matthias Monhart, Andreas Schötzau, Anna A Ledolter, Anja M Palmowski-Wolfe

Published in: Documenta Ophthalmologica | Issue 1/2017

Abstract

Purpose

To further improve analysis of the two-flash multifocal electroretinogram (2F-mfERG) in glaucoma in regard to structure–function analysis, using discrete wavelet transform (DWT) analysis.

Methods

Sixty subjects [35 controls and 25 primary open-angle glaucoma (POAG)] underwent 2F-mfERG. Responses were analyzed with the DWT. The DWT level that could best separate POAG from controls was compared to the root-mean-square (RMS) calculations previously used in the analysis of the 2F-mfERG. In a subgroup analysis, structure–function correlation was assessed between DWT, optical coherence tomography and automated perimetry (mf103 customized pattern) for the central 15°.

Results

Frequency level 4 of the wavelet variance analysis (144 Hz, WVA-144) was most sensitive (p < 0.003). It correlated positively with RMS but had a better AUC. Positive relations were found between visual field, WVA-144 and GCIPL thickness. The highest predictive factor for glaucoma diagnostic was seen in the GCIPL, but this improved further by adding the mean sensitivity and WVA-144.

Conclusions

mfERG using WVA analysis improves glaucoma diagnosis, especially when combined with GCIPL and MS.

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Title: Wavelet decomposition analysis in the two-flash multifocal ERG in early glaucoma: a comparison to ganglion cell analysis and visual field
Authors: Livia M Brandao
Matthias Monhart
Andreas Schötzau
Anna A Ledolter
Anja M Palmowski-Wolfe
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Documenta Ophthalmologica / Issue 1/2017
Print ISSN: 0012-4486
Electronic ISSN: 1573-2622
DOI: https://doi.org/10.1007/s10633-017-9593-y

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Wavelet decomposition analysis in the two-flash multifocal ERG in early glaucoma: a comparison to ganglion cell analysis and visual field

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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