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11-07-2022 | Crohn's Disease | PROFILES AND PERSPECTIVES

DDS Perspective: Crohn’s Disease and Increased Intestinal Permeability—Initial Demonstration and Birth Pains

Author: Daniel Hollander

Published in: Digestive Diseases and Sciences | Issue 9/2022

Excerpt

I started to take care of patients with inflammatory bowel diseases (IBD) in the late 1960s. At that time knowledge about the etiology of IBD and its therapy was quite limited. The commonly held belief at that time was that IBD is caused by an abnormal immunological reaction to luminal antigen(s). Most research funding went to attempts to investigate the possibility of immune dysfunction in Crohn’s disease. Many excellent immunologists concentrated on mucosal immune abnormalities but failed to recognize that such a tunnel vision might impede progress towards understanding the pathogenesis of IBD. …

Hollander D, Vadheim CM, Brettholz E, Petersen GM, Delahunty TJ, Rotter JI. Increased intestinal permeability in Crohn’s patients and their relatives: an etiological factor. Ann Intern Med 1986;105:883–885.CrossRef

Pearson AD, Eastman EJ, Laker MF, Craft AW, Nelson R. Intestinal permeability in children with Crohn’s disease and coeliac disease. Br Med J 1982;285:20–21.CrossRef

Ukabam SO, Clamp JR, Cooper BT. Abnormal small intestinal permeability to sugars in patients with Crohn’s disease of the terminal ileum and colon. Digestion 1983;27:70–74.CrossRef

Diamond JM, Wright EM. Biological membranes: the physical basis of ion and nonelectrolyte selectivity. Annu Rev Physiol 1969;31:581–646.CrossRef

Olaison G, Sjodahl R, Tagesson C. Abnormal intestinal permeability in Crohn’s disease. A possible pathogenic factor. Scand J Gastroenterology 1990; 25:321–8.

Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD. Increased intestinal permeability is associated with later development of Crohn’s disease. Gastroenterology 2020;159:2092–2100.CrossRef

Ye D, Guo S, Al-Sadi R, Ma TY. MicroRNA regulation of intestinal epithelial tight junction permeability. Gastroenterology 2011;141:1323–1333.CrossRef

Title: DDS Perspective: Crohn’s Disease and Increased Intestinal Permeability—Initial Demonstration and Birth Pains
Author: Daniel Hollander
Publication date: 11-07-2022
Publisher: Springer US
Keywords: Crohn's Disease
Chronic Inflammatory Bowel Disease
Published in: Digestive Diseases and Sciences / Issue 9/2022
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-022-07614-5

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