Published in:
01-10-2021 | Eosinophilic Esophagitis | EDITORIAL
When Not to Use a Generic: Measuring HRQoL in Chronic Digestive Disease Necessitates the Use of Disease-Specific Questionnaires
Author:
Tiffany H. Taft
Published in:
Digestive Diseases and Sciences
|
Issue 10/2021
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Excerpt
Health-Related Quality of Life (HRQoL) is a complex, subjective construct that encompasses patient perceptions of the social, emotional, occupational, functional, and financial effects of a chronic medical condition [
1]. Guidance from the US Food and Drug Administration (FDA) strongly encourages measuring HRQoL as a secondary outcome in pharmaceutical clinical trials, further emphasizing the importance of questionnaire selection. In this issue of
Digestive Diseases and Sciences, Chang and colleagues [
2] report on how the MOS Short-Form 36 (SF-36), a widely used cross-condition measure of HRQoL, relates to symptom severity in a cohort of patients with eosinophilic esophagitis (EoE). The authors conclude the SF-36 may have limitations as a tool to evaluate HRQoL in these patients. …