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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 8/2020

01-08-2020 | Famotidine | Correspondence

Repurposed GI Drugs in the Treatment of COVID-19

Authors: Enrik John T. Aguila, Ian Homer Y. Cua

Published in: Digestive Diseases and Sciences | Issue 8/2020

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Excerpt

We read with great interest the review article authored by Dr. Kopel and colleagues. Their study discussed on different therapies that are being investigated for the treatment of COVID-19 [1]. Recently, there have been studies regarding antisecretory agents as repurposed drugs. We would like to highlight the evidence of these common GI drugs and their potentials in the treatment of COVID-19. …
Literature
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Bourinbaiar AS, Fruhstorfer EC. The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: Identification of a new class of antiviral agents. Life Sci. 1996;59(23):365–370.CrossRef
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Shen LW, et al. TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. Biochimie. 2017;142:1–10.CrossRef
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Kopel J, Perisetti A, Gajendran M, et al. Clinical insights into the gastrointestinal manifestations of COVID-19. Dig Dis Sci. 2020;05(23/2020):1–8.
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Sasaki T, Yamaya M, Yasuda H, et al. The proton pump inhibitor lansoprazole inhibits rhinovirus infection in cultured human tracheal epithelial cells. Eur J Pharmacol.. 2005;509(2–3):201–210.CrossRef
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Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol.. 2004;203(2):631–637.CrossRef
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Metadata
Title
Repurposed GI Drugs in the Treatment of COVID-19
Authors
Enrik John T. Aguila
Ian Homer Y. Cua
Publication date
01-08-2020
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 8/2020
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-020-06430-z

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