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Published in: Digestive Diseases and Sciences 12/2017

01-12-2017 | Review

Recent Advances in the Pharmacological Management of Gastroesophageal Reflux Disease

Authors: Yu-Min Kung, Wen-Hung Hsu, Meng-Chieh Wu, Jiunn-Wei Wang, Chung-Jung Liu, Yu-Chung Su, Chao-Hung Kuo, Fu-Chen Kuo, Deng-Chyang Wu, Yao-Kuang Wang

Published in: Digestive Diseases and Sciences | Issue 12/2017

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Abstract

The management of proton pump inhibitor-refractory GERD (rGERD) is a challenge in clinical practice. Since up to one-third of patients with typical GERD symptoms (heartburn and/or acid regurgitation) are not satisfied with proton pump inhibitor (PPI) therapy, new drug development targeting different pathophysiologies of GERD is imperative. At present, no other drugs serve as a more potent acid suppression agent than PPIs. As an add-on therapy, histamine type-2 receptor antagonists, alginates, prokinetics and transient lower esophageal sphincter relaxation inhibitors have some impact on the subgroups of rGERD, but greater effectiveness and fewer adverse effects for widespread use are required. Visceral hypersensitivity also contributes to the perception of GERD symptoms, and neuromodulators including antidepressants play a role in this category. Esophageal pH-impedance monitoring helps to distinguish functional heartburn from true GERD, and psychologic medication and cognitive behavior therapy are further therapy options instead of PPIs.
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Metadata
Title
Recent Advances in the Pharmacological Management of Gastroesophageal Reflux Disease
Authors
Yu-Min Kung
Wen-Hung Hsu
Meng-Chieh Wu
Jiunn-Wei Wang
Chung-Jung Liu
Yu-Chung Su
Chao-Hung Kuo
Fu-Chen Kuo
Deng-Chyang Wu
Yao-Kuang Wang
Publication date
01-12-2017
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 12/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4830-5

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