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Published in: Digestive Diseases and Sciences 12/2017

01-12-2017 | Editorial

Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders

Authors: Jonathan Gotfried, Ron Schey

Published in: Digestive Diseases and Sciences | Issue 12/2017

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Excerpt

Nausea is an unpleasant sensation typically experienced in the epigastrium or throat, often accompanied by the impending urge to vomit [1]. While the neural pathways involved with nausea and emesis are generally well defined, the specific pathways involved in the nausea mechanism are not fully elucidated. Within the gastrointestinal tract, mechanical obstruction, organic disorders such as peptic ulcer disease or malignancy, and neuromuscular dysfunction such as chronic intestinal pseudo-obstruction and gastroparesis may all lead to nausea. Medications, chemotherapy, and ingested noxious agents also contribute to the pathogenesis of nausea, mainly through recognition of circulating emetic agents in the blood by central chemoreceptors [2]. Nausea is an oft-cited adverse effect of medications that often prompts therapy discontinuation. …
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Metadata
Title
Analysis of Nausea in Clinical Studies of Lubiprostone for the Treatment of Constipation Disorders
Authors
Jonathan Gotfried
Ron Schey
Publication date
01-12-2017
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 12/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4773-x

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