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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 10/2017

01-10-2017 | Concise Commentary

Therapeutic Potential of the Gabaergic System in Ulcerative Colitis: Current Status and Perspectives

Authors: Maria Grazia Zizzo, Rosa Serio

Published in: Digestive Diseases and Sciences | Issue 10/2017

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Excerpt

An extensive body of literature supports the physiological and pathological importance of γ-amino butyric acid (GABA)ergic signalling in the gut. Although the functional significance of GABA in the gastrointestinal tract is still a matter of debate, GABA may contribute to the “neuroimmune dialogue” between the enteric nervous system and the intestinal mucosal immune system during inflammatory events [1] such as with the prototypic gut inflammatory disease, inflammatory bowel disease (IBD). …
Literature
1.
Auteri M, Zizzo MG, Serio R. The GABAergic system and the gastrointestinal physiopathology. Curr Pharm Des. 2015;21:4996–5016.CrossRefPubMed
2.
Aggarwal S, Ahuja V, Paul J. Attenuated GABAergic signaling in intestinal epithelium contributes to pathogenesis of ulcerative colitis. Dig Dis Sci. (Epub ahead of print). doi:10.​1007/​s10620-017-4662-3.
3.
Metadata
Title
Therapeutic Potential of the Gabaergic System in Ulcerative Colitis: Current Status and Perspectives
Authors
Maria Grazia Zizzo
Rosa Serio
Publication date
01-10-2017
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 10/2017
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-017-4709-5

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