Skip to main content
Top
Published in: Digestive Diseases and Sciences 1/2015

01-01-2015 | Editorial

Fat and Fiber: How the Controlled Attenuation Parameter Complements Noninvasive Assessment of Liver Fibrosis

Authors: Grace Lai-Hung Wong, Vincent Wai-Sun Wong

Published in: Digestive Diseases and Sciences | Issue 1/2015

Login to get access

Excerpt

Nonalcoholic fatty liver disease (NAFLD) is an ever-growing problem in the developed and developing worlds, affecting 15–40 % of the population [1]. Once regarded as a benign condition, NAFLD is the leading cause of cryptogenic cirrhosis and cryptogenic hepatocellular carcinoma (HCC) [2], and the third most frequent indication for liver transplantation [3]. …
Literature
1.
go back to reference Wong VW, Chu WC, Wong GL, et al. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut. 2012;61:409–415.PubMedCrossRef Wong VW, Chu WC, Wong GL, et al. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut. 2012;61:409–415.PubMedCrossRef
2.
go back to reference Wong VW, Wong GL, Choi PC, et al. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut. 2010;59:969–974.PubMedCrossRef Wong VW, Wong GL, Choi PC, et al. Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut. 2010;59:969–974.PubMedCrossRef
3.
go back to reference Charlton MR, Burns JM, Pedersen RA, et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141:1249–1253.PubMedCrossRef Charlton MR, Burns JM, Pedersen RA, et al. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141:1249–1253.PubMedCrossRef
4.
go back to reference Chan HL, de Silva HJ, Leung NW, et al. How should we manage patients with non-alcoholic fatty liver disease in 2007? J Gastroenterol Hepatol. 2007;22:801–808.PubMedCrossRef Chan HL, de Silva HJ, Leung NW, et al. How should we manage patients with non-alcoholic fatty liver disease in 2007? J Gastroenterol Hepatol. 2007;22:801–808.PubMedCrossRef
5.
go back to reference Clouston AD, Jonsson JR, Powell EE. Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. Clin Liver Dis. 2007;11:173–189, x. Clouston AD, Jonsson JR, Powell EE. Steatosis as a cofactor in other liver diseases: hepatitis C virus, alcohol, hemochromatosis, and others. Clin Liver Dis. 2007;11:173–189, x.
6.
go back to reference Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123:745–750.PubMedCrossRef Saadeh S, Younossi ZM, Remer EM, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology. 2002;123:745–750.PubMedCrossRef
7.
go back to reference Wong VW, Vergniol J, Wong GL, et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology. 2010;51:454–462.PubMedCrossRef Wong VW, Vergniol J, Wong GL, et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology. 2010;51:454–462.PubMedCrossRef
9.
go back to reference Sasso M, Beaugrand M, de Ledinghen V, et al. Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol. 2010;36:1825–1835.PubMedCrossRef Sasso M, Beaugrand M, de Ledinghen V, et al. Controlled attenuation parameter (CAP): a novel VCTE guided ultrasonic attenuation measurement for the evaluation of hepatic steatosis: preliminary study and validation in a cohort of patients with chronic liver disease from various causes. Ultrasound Med Biol. 2010;36:1825–1835.PubMedCrossRef
10.
go back to reference de Ledinghen V, Vergniol J, Foucher J, et al. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography. Liver Int. 2012;32:911–918.PubMedCrossRef de Ledinghen V, Vergniol J, Foucher J, et al. Non-invasive diagnosis of liver steatosis using controlled attenuation parameter (CAP) and transient elastography. Liver Int. 2012;32:911–918.PubMedCrossRef
11.
go back to reference Myers RP, Pollett A, Kirsch R, et al. Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography. Liver Int. 2012;32:902–910.PubMedCrossRef Myers RP, Pollett A, Kirsch R, et al. Controlled Attenuation Parameter (CAP): a noninvasive method for the detection of hepatic steatosis based on transient elastography. Liver Int. 2012;32:902–910.PubMedCrossRef
12.
go back to reference Sasso M, Tengher-Barna I, Ziol M, et al. Novel controlled attenuation parameter for noninvasive assessment of steatosis using Fibroscan((R)): validation in chronic hepatitis C. J Viral Hepat. 2012;19:244–253.PubMedCrossRef Sasso M, Tengher-Barna I, Ziol M, et al. Novel controlled attenuation parameter for noninvasive assessment of steatosis using Fibroscan((R)): validation in chronic hepatitis C. J Viral Hepat. 2012;19:244–253.PubMedCrossRef
14.
go back to reference Beaugrand M, de Ledinghen V, Douvin C, et al. Validation of controlled attenuation parameter (CAP) as a non-invasive marker of steatosis in 228 patients with chronic liver disease from various causes. J Hepatol. 2010;52:S35–S36. Beaugrand M, de Ledinghen V, Douvin C, et al. Validation of controlled attenuation parameter (CAP) as a non-invasive marker of steatosis in 228 patients with chronic liver disease from various causes. J Hepatol. 2010;52:S35–S36.
15.
go back to reference Beaugrand M, Ziol M, de Ledinghen V, et al. Controlled attenuation parameter: A novel FibroScan®-based tool to detect and quantify steatosis. Preliminary study in patient with alcoholoc and non alcoholic fatty liver disease. J Hepatol. 2010;52:S158–S159. Beaugrand M, Ziol M, de Ledinghen V, et al. Controlled attenuation parameter: A novel FibroScan®-based tool to detect and quantify steatosis. Preliminary study in patient with alcoholoc and non alcoholic fatty liver disease. J Hepatol. 2010;52:S158–S159.
16.
go back to reference Chon YE, Jung KS, Kim KJ, et al. Normal controlled attenuation parameter values: a prospective study of healthy subjects undergoing health checkups and liver donors in Korea. Dig Dis Sci. (Epub ahead of print). doi:10.1007/s10620-014-3293-1. Chon YE, Jung KS, Kim KJ, et al. Normal controlled attenuation parameter values: a prospective study of healthy subjects undergoing health checkups and liver donors in Korea. Dig Dis Sci. (Epub ahead of print). doi:10.​1007/​s10620-014-3293-1.
17.
go back to reference Mi YQ, Shi QY, Zu L, et al. Controlled attenuation parameter for noninvasive assessment of hepatic steatosis using Fibroscan(®): validation in chronic hepatitis B. Dig Dis Sci. (Epub ahead of print). doi:10.1007/s10620-014-3341-x. Mi YQ, Shi QY, Zu L, et al. Controlled attenuation parameter for noninvasive assessment of hepatic steatosis using Fibroscan(®): validation in chronic hepatitis B. Dig Dis Sci. (Epub ahead of print). doi:10.​1007/​s10620-014-3341-x.
18.
go back to reference Wong GL, Wong VW, Choi PC, et al. Increased liver stiffness measurement by transient elastography in severe acute exacerbation of chronic hepatitis B. J Gastroenterol Hepatol. 2009;24:1002–1007.PubMedCrossRef Wong GL, Wong VW, Choi PC, et al. Increased liver stiffness measurement by transient elastography in severe acute exacerbation of chronic hepatitis B. J Gastroenterol Hepatol. 2009;24:1002–1007.PubMedCrossRef
19.
go back to reference Chan HL, Wong GL, Choi PC, et al. Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B. J Viral Hepat. 2009;16:36–44.PubMedCrossRef Chan HL, Wong GL, Choi PC, et al. Alanine aminotransferase-based algorithms of liver stiffness measurement by transient elastography (Fibroscan) for liver fibrosis in chronic hepatitis B. J Viral Hepat. 2009;16:36–44.PubMedCrossRef
20.
go back to reference Wong VW, Wong GL, Chu WC, et al. Hepatitis B virus infection and fatty liver in the general population. J Hepatol. 2012;56:533–540.PubMedCrossRef Wong VW, Wong GL, Chu WC, et al. Hepatitis B virus infection and fatty liver in the general population. J Hepatol. 2012;56:533–540.PubMedCrossRef
21.
go back to reference Wong GL, Chan HL, Yu Z, et al. Coincidental metabolic syndrome increases the risk of liver fibrosis progression in patients with chronic hepatitis B—a prospective cohort study with paired transient elastography examinations. Aliment Pharmacol Ther. 2014;39:883–893.PubMedCrossRef Wong GL, Chan HL, Yu Z, et al. Coincidental metabolic syndrome increases the risk of liver fibrosis progression in patients with chronic hepatitis B—a prospective cohort study with paired transient elastography examinations. Aliment Pharmacol Ther. 2014;39:883–893.PubMedCrossRef
22.
go back to reference Wong GL, Wong VW, Choi PC, et al. Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B. Gut. 2009;58:111–117.PubMedCrossRef Wong GL, Wong VW, Choi PC, et al. Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B. Gut. 2009;58:111–117.PubMedCrossRef
23.
go back to reference Wong GL, Chan HL, Wong CK, et al. Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B. J Hepatol. 2014;60:339–345.PubMedCrossRef Wong GL, Chan HL, Wong CK, et al. Liver stiffness-based optimization of hepatocellular carcinoma risk score in patients with chronic hepatitis B. J Hepatol. 2014;60:339–345.PubMedCrossRef
Metadata
Title
Fat and Fiber: How the Controlled Attenuation Parameter Complements Noninvasive Assessment of Liver Fibrosis
Authors
Grace Lai-Hung Wong
Vincent Wai-Sun Wong
Publication date
01-01-2015
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 1/2015
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-014-3429-3

Other articles of this Issue 1/2015

Digestive Diseases and Sciences 1/2015 Go to the issue