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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 9/2013

01-09-2013 | Editorial

Activation of Signaling Pathways Following Intestinal Resection: Turning It Up a Notch?

Author: Yongjia Feng

Published in: Digestive Diseases and Sciences | Issue 9/2013

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Excerpt

The intestinal tract is the most rapidly renewed mammalian tissue and thus has highly active stem and transit-amplifying cells that promote renewal of terminally differentiated cells that perform digestive functions. Notch signaling is thought to act directly on stem cells to promote their proliferation and also in progeny precursors to determine absorptive versus secretory terminal differentiation pathways, although Notch signaling may actually enhance cell differentiation with other signaling pathways such as the Wnt-β-catenin pathway promoting cell proliferation. …
Literature
1.
Tang Y, Swietlicki EA, Jiang S, et al. Increased apoptosis and accelerated epithelial migration following inhibition of hedgehog signaling in adaptive small bowel postresection. Am J Physiol Gastrointest Liver Physiol. 2006;290:G1280–G1288.PubMedCrossRef
2.
Bernal NP, Stehr W, Zhang Y, Profitt S, Erwin CR, Warner BW. Evidence for active Wnt signaling during postresection intestinal adaptation. J Pediatr Surg. 2005;40:1025–1029; discussion 1029.
3.
Chen G, Sun L, Yu M, et al. The Jagged-1/Notch-1/Hes-1 pathway is involved in intestinal adaptation in a massive small bowel resection rat model. Dig Dis Sci. (Epub ahead of print). doi: 10.​1007/​s10620-013-2680-3.
4.
Krejci A, Bernard F, Housden BE, Collins S, Bray SJ. Direct response to Notch activation: signaling crosstalk and incoherent logic. Sci Signal. 2009;2:ra1.
5.
Fevr T, Robine S, Louvard D, Huelsken J. Wnt/beta-catenin is essential for intestinal homeostasis and maintenance of intestinal stem cells. Mol Cell Biol. 2007;27:7551–7559.PubMedCrossRef
6.
Korinek V, Barker N, Willert K, et al. Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998;18:1248–1256.PubMed
7.
Hirata A, Utikal J, Yamashita S, et al. Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development. 2013;140:66–75.PubMedCrossRef
8.
Sato T, van Es JH, Snippert HJ, et al. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature. 2011;469:415–418.PubMedCrossRef
9.
VanDussen KL, Carulli AJ, Keeley TM, et al. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development. 2012;139:488–497.PubMedCrossRef
10.
van Es JH, van Gijn ME, Riccio O, et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature. 2005;435:959–963.PubMedCrossRef
11.
Wu Y, Cain-Hom C, Choy L, et al. Therapeutic antibody targeting of individual Notch receptors. Nature. 2010;464:1052–1057.PubMedCrossRef
Metadata
Title
Activation of Signaling Pathways Following Intestinal Resection: Turning It Up a Notch?
Author
Yongjia Feng
Publication date
01-09-2013
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 9/2013
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-013-2761-3

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