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Published in:

01-04-2012 | Original Article

Genetic Variation in the Peroxisome Proliferator Activated Receptor-Gamma Gene Is Associated with Histologically Advanced NAFLD

Authors: Samer Gawrieh, Miranda C. Marion, Richard Komorowski, James Wallace, Michael Charlton, Ahmed Kissebah, Carl D. Langefeld, Michael Olivier

Published in: Digestive Diseases and Sciences | Issue 4/2012

Abstract

Background

The peroxisome proliferator activated receptor-gamma (PPARG) is a nuclear receptor that regulates adipocyte differentiation, insulin sensitivity and lipid metabolism, thus, it represents a good candidate gene for non-alcoholic fatty liver disease (NAFLD).

Purpose and Method

We investigated the association of two PPARG variants (Pro12Ala and C1431T) with NAFLD and its histological features. DNA was extracted from 274 archived, formalin-fixed liver biopsy specimens from 212 patients with NAFLD and 62 controls with normal liver histology.

Results

Individual SNPs did not show significant association with NAFLD or its histological features. A haplotype comprised of both minor alleles (GT) was less enriched whereas a haplotype comprised of the two major alleles (CC) was more enriched in subjects with NAFLD compared to controls [9.3% vs. 28.1% for GT (P = 0.001, OR 0.26 (range 0.14–0.48) and 80.4% vs. 64.8% for CC (P = 0.037, OR 2.23 (range 1.30–3.81)]. Both haplotypes were significantly associated with steatosis and fibrosis. The GT haplotype was also associated with lobular inflammation.

Conclusions

Genetic variation in PPARG is associated with NAFLD, and the GT haplotype is associated with inflammatory and fibrotic changes that denote histologically advanced NAFLD.

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Title: Genetic Variation in the Peroxisome Proliferator Activated Receptor-Gamma Gene Is Associated with Histologically Advanced NAFLD
Authors: Samer Gawrieh
Miranda C. Marion
Richard Komorowski
James Wallace
Michael Charlton
Ahmed Kissebah
Carl D. Langefeld
Michael Olivier
Publication date: 01-04-2012
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 4/2012
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-011-1994-2

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Abstract

Background

Purpose and Method

Results

Conclusions

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