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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 5/2010

01-05-2010 | Correspondence

Low Prevalence of CMV Infection in Patients with Crohn’s Disease in Comparison with Ulcerative Colitis: Effect of Different Immune Response on Prevalence of CMV Infection

Authors: Hiroshi Nakase, Takuya Yoshino, Yusuke Honzawa, Tsutomu Chiba

Published in: Digestive Diseases and Sciences | Issue 5/2010

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Excerpt

We read with great interest the original article of Kim et al. [1] on cytomegalovirus (CMV) infection in patients with active inflammatory bowel disease. In this article, the authors focused on incidence of CMV infection in patients with UC. However, we were very interested in the lower incidence of CMV infection in CD patients in comparison with that in UC patients. The authors demonstrated that 12 of the 120 patients with UC and none of the 20 patients with CD had CMV infection, although there were a limited number of patients with CD enrolled in this study. Why was the incidence of CMV infection lower in patients with CD than in those with UC? …
Literature
1.
Kim JJ, Simpson N, Klipfel N, et al. Cytomegalovirus infection in patients with active inflammatory bowel disease. Dig Dis Sci. 2010; Jan 29. [Epub ahead of print].
2.
Kou T, Nakase H, Tamaki H, et al. Cytomegalovirus infection in patients with ulcerative colitis diagnosed by quantitative real-time PCR analysis. Dig Dis Sci. 2006;51:1052–1055.CrossRefPubMed
3.
Yoshino T, Nakase H, Ueno S, et al. Usefulness of quantitative real-time PCR assay for early detection of cytomegalovirus infection in patients with ulcerative colitis refractory to immunosuppressive therapies. Inflamm Bowel Dis. 2007;13:1516–1521.CrossRefPubMed
4.
Nakase H, Matsumura K, Yoshino T, et al. Systematic review: cytomegalovirus infection in inflammatory bowel disease. J Gastroenterol. 2008;43:735–740.CrossRefPubMed
5.
Waldrop SL, Pitcher CJ, Peterson DM, et al. Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry. J Clin Invest. 1997;99:1739–1750.CrossRefPubMed
6.
Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol. 1996;157:1261–1270.PubMed
Metadata
Title
Low Prevalence of CMV Infection in Patients with Crohn’s Disease in Comparison with Ulcerative Colitis: Effect of Different Immune Response on Prevalence of CMV Infection
Authors
Hiroshi Nakase
Takuya Yoshino
Yusuke Honzawa
Tsutomu Chiba
Publication date
01-05-2010
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 5/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-010-1162-0

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