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01-05-2010 | Original Article

Gastric Hyposecretion in Esophageal Squamous-Cell Carcinomas

Authors: K. Iijima, T. Koike, Y. Abe, H. Yamagishi, N. Ara, K. Asanuma, K. Uno, A. Imatani, N. Nakaya, S. Ohara, T. Shimosegawa

Published in: Digestive Diseases and Sciences | Issue 5/2010

Abstract

Recently, gastric fundic atrophy is reported to be an independent risk factor for esophageal squamous-cell carcinoma (ESCC). The aim of this study is to investigate the acid secretory level in ESCC in a case-control study. From April 2004 to March 2008, 100 consecutive subjects with early ESCC and 100 age- and sex-matched asymptomatic controls were prospectively enrolled. Gastrin-stimulated acid output was assessed by endoscopic gastrin test. Conditional regression analyses were used to adjust for other potential confounders. Multivariate analyses revealed a strong association between profound hypochlorhydria and ESCC with odds ratio (95% confidence interval): 6.0 (1.9–18.4). The association remained significant after adjusting for the effect of gastric atrophy as a covariate. The association became stronger as the ESCC developed more distal site of the esophagus. This study indicates that profound hypochlorhydria is a strong independent risk factor for ESCC even after adjusting for the influence of gastric atrophy.

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Title: Gastric Hyposecretion in Esophageal Squamous-Cell Carcinomas
Authors: K. Iijima
T. Koike
Y. Abe
H. Yamagishi
N. Ara
K. Asanuma
K. Uno
A. Imatani
N. Nakaya
S. Ohara
T. Shimosegawa
Publication date: 01-05-2010
Publisher: Springer US
Published in: Digestive Diseases and Sciences / Issue 5/2010
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-009-0853-x

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