Skip to main content
Top
Published in: Digestive Diseases and Sciences 6/2009

01-06-2009 | Review

Hepatitis C Virus and Inflammatory Bowel Disease

Authors: Todd L. Horn, Joel Reynolds, Willem de Villiers, Luis R. Peña

Published in: Digestive Diseases and Sciences | Issue 6/2009

Login to get access

Abstract

Gastroenterologists frequently treat patients with complex illnesses such as chronic hepatitis C infections and inflammatory bowel disease (IBD). Occasionally, a patient will present with these two diseases which behave very differently and the treatment for one may potentially exacerbate the other. The purpose of this article is to review the current literature regarding hepatitis C virus therapy in the setting of IBD as well as the effects of common IBD therapies on the hepatitis C virus. Based on limited data, anti-viral therapy is probably safe in patients with well-controlled IBD, but there might be a risk of causing new onset of IBD. Also, it does not appear that the commonly used medications for IBD have much of an effect on the hepatitis C virus (HCV) or its course.
Literature
1.
go back to reference Longo F, Hebuterne X, Tran A, et al. Prevalence of hepatitis C in patients with chronic inflammatory bowel disease in the region of Nice and evaluation of risk factors. Gastroenterol Clin Biol. 2000;24(1):77–81.PubMed Longo F, Hebuterne X, Tran A, et al. Prevalence of hepatitis C in patients with chronic inflammatory bowel disease in the region of Nice and evaluation of risk factors. Gastroenterol Clin Biol. 2000;24(1):77–81.PubMed
2.
go back to reference Bronowicki JP, Barraud H, Peyrin-Biroulet L. Epidemiology and natural history of hepatitis C. Rev Prat. 2005;55(6):607–614.PubMed Bronowicki JP, Barraud H, Peyrin-Biroulet L. Epidemiology and natural history of hepatitis C. Rev Prat. 2005;55(6):607–614.PubMed
5.
8.
go back to reference Niki T, Nishida K, Honsako Y, et al. A case of ulcerative colitis along with characteristic features on computed tomography (CT), developed by the treatment with interferon for chronic hepatitis C. Nippon Shokakibyo Gakkai Zasshi. 2001;98(4):399–404.PubMed Niki T, Nishida K, Honsako Y, et al. A case of ulcerative colitis along with characteristic features on computed tomography (CT), developed by the treatment with interferon for chronic hepatitis C. Nippon Shokakibyo Gakkai Zasshi. 2001;98(4):399–404.PubMed
11.
go back to reference Yamamoto Y, Sakatani N, Yano S, et al. Interferon-induced IBD-like acute colitis–two cases of patients with chronic active hepatitis. Nippon Shokakibyo Gakkai Zasshi. 1995;92(9):1293–1296.PubMed Yamamoto Y, Sakatani N, Yano S, et al. Interferon-induced IBD-like acute colitis–two cases of patients with chronic active hepatitis. Nippon Shokakibyo Gakkai Zasshi. 1995;92(9):1293–1296.PubMed
12.
go back to reference Cottone M, Magliocco A, Trallori G, et al. Clinical course of inflammatory bowel disease during treatment with interferon for associated chronic active hepatitis. Ital J Gastroenterol. 1995;27(1):3–4.PubMed Cottone M, Magliocco A, Trallori G, et al. Clinical course of inflammatory bowel disease during treatment with interferon for associated chronic active hepatitis. Ital J Gastroenterol. 1995;27(1):3–4.PubMed
13.
go back to reference Bargiggia S, Thorburn D, Anderloni A, et al. Is interferon-alpha therapy safe and effective for patients with chronic hepatitis C and inflammatory bowel disease? A case-control study. Aliment Pharmacol Ther. 2005;22(3):209–215.PubMedCrossRef Bargiggia S, Thorburn D, Anderloni A, et al. Is interferon-alpha therapy safe and effective for patients with chronic hepatitis C and inflammatory bowel disease? A case-control study. Aliment Pharmacol Ther. 2005;22(3):209–215.PubMedCrossRef
18.
go back to reference Wendling D, Auge B, Bettinger D, et al. Reactivation of a latent precore mutant hepatitis B virus-related chronic hepatitis during infliximab treatment for severe spondyloarthropathy. Ann Rheum Dis. 2005;64:788–789. doi:10.1136/ard.2004.031187.PubMedCrossRef Wendling D, Auge B, Bettinger D, et al. Reactivation of a latent precore mutant hepatitis B virus-related chronic hepatitis during infliximab treatment for severe spondyloarthropathy. Ann Rheum Dis. 2005;64:788–789. doi:10.​1136/​ard.​2004.​031187.PubMedCrossRef
19.
go back to reference Ostuni P, Botsios C, Punzi L, et al. Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low-dose methotrexate. Ann Rheum Dis. 2003;62:686–687. doi:10.1136/ard.62.7.686.PubMedCrossRef Ostuni P, Botsios C, Punzi L, et al. Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low-dose methotrexate. Ann Rheum Dis. 2003;62:686–687. doi:10.​1136/​ard.​62.​7.​686.PubMedCrossRef
20.
go back to reference Michel M, Duvoux C, Hezode C, et al. Fulminant hepatitis after infliximab in a patient with hepatitis B virus treated for an adult-onset Still’s disease. J Rheum. 2003;30:1624–1625.PubMed Michel M, Duvoux C, Hezode C, et al. Fulminant hepatitis after infliximab in a patient with hepatitis B virus treated for an adult-onset Still’s disease. J Rheum. 2003;30:1624–1625.PubMed
21.
go back to reference Peterson JR, Hsu FC, Simkin PA, et al. Effect of tumor necrosis factor alpha antagonists on serum transaminases and viraemia in patients with rheumatoid arthritis and chronic hepatitis C infection. Ann Rheum Dis. 2003;62:1078–1082. doi:10.1136/ard.62.11.1078.PubMedCrossRef Peterson JR, Hsu FC, Simkin PA, et al. Effect of tumor necrosis factor alpha antagonists on serum transaminases and viraemia in patients with rheumatoid arthritis and chronic hepatitis C infection. Ann Rheum Dis. 2003;62:1078–1082. doi:10.​1136/​ard.​62.​11.​1078.PubMedCrossRef
22.
go back to reference Oniankitan O, Duvoux C, Challine D, et al. Infliximab therapy for rheumatic diseases in patients with chronic hepatitis B or C. J Rheum. 2004;31:107–109.PubMed Oniankitan O, Duvoux C, Challine D, et al. Infliximab therapy for rheumatic diseases in patients with chronic hepatitis B or C. J Rheum. 2004;31:107–109.PubMed
25.
go back to reference Aslanidis S, Vassiliadis T, Pyrpasopoulou A, et al. Inhibition of TNF-alpha does not induce viral reactivation in patients with chronic hepatitis C infection: two cases. Clin Rheumatol. 2007;26(2):261–264. doi:10.1007/s10067-006-0394-z.PubMedCrossRef Aslanidis S, Vassiliadis T, Pyrpasopoulou A, et al. Inhibition of TNF-alpha does not induce viral reactivation in patients with chronic hepatitis C infection: two cases. Clin Rheumatol. 2007;26(2):261–264. doi:10.​1007/​s10067-006-0394-z.PubMedCrossRef
26.
go back to reference Pitarch G, Sanchez-Carazo JL, Mahiques L, et al. Treatment of psoriasis with adalimumab. Clin Exp Dermatol. 2007;32(1):18–22.PubMed Pitarch G, Sanchez-Carazo JL, Mahiques L, et al. Treatment of psoriasis with adalimumab. Clin Exp Dermatol. 2007;32(1):18–22.PubMed
29.
go back to reference Zein NN, Etanercept Study Group. Etanercept as an adjuvant to interferon and ribavirin in treatment-naïve patients with chronic hepatitis C virus infection: a phase 2 randomized, double-blind, placebo-controlled study. J Hepatol. 2005;42(3):315–322. doi:10.1016/j.jhep.2004.11.025.PubMedCrossRef Zein NN, Etanercept Study Group. Etanercept as an adjuvant to interferon and ribavirin in treatment-naïve patients with chronic hepatitis C virus infection: a phase 2 randomized, double-blind, placebo-controlled study. J Hepatol. 2005;42(3):315–322. doi:10.​1016/​j.​jhep.​2004.​11.​025.PubMedCrossRef
30.
go back to reference Nathan DM, Angus PW, Gibson PR. Hepatitis B and C virus infections and anti-tumor necrosis factor-alpha therapy: guidelines for clinical approach. J Gastroenterol Hepatol. 2006;21(9):1366–1371.PubMedCrossRef Nathan DM, Angus PW, Gibson PR. Hepatitis B and C virus infections and anti-tumor necrosis factor-alpha therapy: guidelines for clinical approach. J Gastroenterol Hepatol. 2006;21(9):1366–1371.PubMedCrossRef
32.
go back to reference Samonakis DN, Triantos CK, et al. Immunosuppression and donor age with respect to severity of HCV recurrence after liver transplantation. Liver Transpl. 2005;11(4):384–385. doi:10.1002/lt.20344.CrossRef Samonakis DN, Triantos CK, et al. Immunosuppression and donor age with respect to severity of HCV recurrence after liver transplantation. Liver Transpl. 2005;11(4):384–385. doi:10.​1002/​lt.​20344.CrossRef
33.
go back to reference Zekry A, Gleeson M, Guney S, et al. A prospective cross-over study comparing the effect of mycophenolate versus azathioprine on allograft function and viral load in liver transplant recipients with recurrent chronic HCV infection. Liver Transpl. 2004;10(1):52–57. doi:10.1002/lt.20000.PubMedCrossRef Zekry A, Gleeson M, Guney S, et al. A prospective cross-over study comparing the effect of mycophenolate versus azathioprine on allograft function and viral load in liver transplant recipients with recurrent chronic HCV infection. Liver Transpl. 2004;10(1):52–57. doi:10.​1002/​lt.​20000.PubMedCrossRef
34.
go back to reference Walter T, Dumortier J, Guillaud O, et al. Factors influencing the progression of fibrosis in patients with recurrent hepatitis C after liver transplantation under antiviral therapy: a retrospective analysis of 939 liver biopsiesin a single center. Liver Transpl. 2007;13(2):294–301. doi:10.1002/lt.21000.PubMedCrossRef Walter T, Dumortier J, Guillaud O, et al. Factors influencing the progression of fibrosis in patients with recurrent hepatitis C after liver transplantation under antiviral therapy: a retrospective analysis of 939 liver biopsiesin a single center. Liver Transpl. 2007;13(2):294–301. doi:10.​1002/​lt.​21000.PubMedCrossRef
35.
go back to reference Contreras AM, Monteon FJ, Flores MR, et al. Drug-related hepatotoxicity in a renal transplant recipient with long-term survival and hepatitis C. Ann Hepatol. 2007;6(1):70–73.PubMed Contreras AM, Monteon FJ, Flores MR, et al. Drug-related hepatotoxicity in a renal transplant recipient with long-term survival and hepatitis C. Ann Hepatol. 2007;6(1):70–73.PubMed
36.
go back to reference Mok MY, Ng WL, Yuen MF, et al. Safety of disease modifying anti-rheumatic agents in rheumatoid arthritis patients with chronic viral hepatitis. Clin Exp Rheumatol. 2000;18(3):363–368.PubMed Mok MY, Ng WL, Yuen MF, et al. Safety of disease modifying anti-rheumatic agents in rheumatoid arthritis patients with chronic viral hepatitis. Clin Exp Rheumatol. 2000;18(3):363–368.PubMed
37.
go back to reference Kujawska A, Clements M, Wise CM, et al. Hepatitis C and methotrexate. Arthritis Rheum. 2003;49(6):843–845.PubMedCrossRef Kujawska A, Clements M, Wise CM, et al. Hepatitis C and methotrexate. Arthritis Rheum. 2003;49(6):843–845.PubMedCrossRef
38.
go back to reference Firpi RJ, Zhu H, Morelli G, et al. Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation. Liver Transpl. 2006;12(1):51–57. doi:10.1002/lt.20532.PubMedCrossRef Firpi RJ, Zhu H, Morelli G, et al. Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation. Liver Transpl. 2006;12(1):51–57. doi:10.​1002/​lt.​20532.PubMedCrossRef
39.
go back to reference Schiavon LL, Carvalho-Filho RJ, Narciso-Schiavon JL, et al. Impact of cyclosporine-based immunosuppressive therapy on liver histology of hepatitis C virus-infected renal transplant patients. Hepatology. 2008;48(1):348–349. doi:10.1002/hep.22331.PubMedCrossRef Schiavon LL, Carvalho-Filho RJ, Narciso-Schiavon JL, et al. Impact of cyclosporine-based immunosuppressive therapy on liver histology of hepatitis C virus-infected renal transplant patients. Hepatology. 2008;48(1):348–349. doi:10.​1002/​hep.​22331.PubMedCrossRef
40.
go back to reference Wiesner RH, Shorr JS, Steffen BJ, et al. Mycophenolate mofetil combination therapy improves long-term outcomes after liver transplantation in patients with and without hepatitis C. Liver Transpl. 2005;11(7):750–759. doi:10.1002/lt.20453.PubMedCrossRef Wiesner RH, Shorr JS, Steffen BJ, et al. Mycophenolate mofetil combination therapy improves long-term outcomes after liver transplantation in patients with and without hepatitis C. Liver Transpl. 2005;11(7):750–759. doi:10.​1002/​lt.​20453.PubMedCrossRef
42.
go back to reference Kato T, Gaynor JJ, Yoshida H, et al. Randomized trial of steroid-free induction versus corticosteroid maintenance among orthotopic liver transplant recipients with hepatitis C virus: impact on hepatic fibrosis progression at 1 year. Transplantation. 2007;84(7):829–835.PubMedCrossRef Kato T, Gaynor JJ, Yoshida H, et al. Randomized trial of steroid-free induction versus corticosteroid maintenance among orthotopic liver transplant recipients with hepatitis C virus: impact on hepatic fibrosis progression at 1 year. Transplantation. 2007;84(7):829–835.PubMedCrossRef
Metadata
Title
Hepatitis C Virus and Inflammatory Bowel Disease
Authors
Todd L. Horn
Joel Reynolds
Willem de Villiers
Luis R. Peña
Publication date
01-06-2009
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 6/2009
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-008-0489-2

Other articles of this Issue 6/2009

Digestive Diseases and Sciences 6/2009 Go to the issue