Top

Published in:

01-03-2007 | Case Report

Diffuse Desmoplastic Metastatic Breast Cancer Simulating Cirrhosis with Severe Portal Hypertension: A Case of “Pseudocirrhosis”

Authors: David A. Sass, Kenneth Clark, Dana Grzybicki, Mordechai Rabinovitz, Thomas A. Shaw-Stiffel

Published in: Digestive Diseases and Sciences | Issue 3/2007

Excerpt

Hepatic metastases from breast cancer can occasionally mimic cirrhosis anatomically, in both the presence and the absence of prior systemic chemotherapy [1‐3]. We present a case of diffuse desmoplastic metastatic breast carcinoma (Ca) masquerading as cirrhosis that presented with new-onset jaundice associated with severe portal hypertension and its sequelae. This case also serves as a background for a discussion of both the role of ¹⁸FDG-PET scanning in metastatic breast cancer and the entity of tamoxifen-induced hepatotoxicity. …

Young ST, Paulson EK, Washington K, Gulliver DJ, Vredenburgh JJ, Baker ME (1994) CT of the liver in patients with metastatic breast carcinoma treated by chemotherapy: findings simulating cirrhosis. AJR 163:1385–1388PubMed

Nascimento AB, Mitchell DG, Rubin R, Weaver E (2001) Diffuse desmoplastic breast carcinoma metastases to the liver simulating cirrhosis at MR imaging: report of two cases. Radiology 221:117–121PubMed

Shirkhoda A, Baird S (1994) Morphologic changes of the liver following chemotherapy for metastatic breast carcinoma: CT findings. Abdom Imaging 19:39–42PubMedCrossRef

Fennessy FM, Mortele KJ, Kluckert T, Gogate A, Ondategui-Parra S, Ros P, Silverman SG (2004) Hepatic capsular retraction in metastatic carcinoma of the breast occurring with increase or decrease in size of subjacent metastasis. AJR 182:651–655PubMed

Moon DH, Maddahi J, Silverman DHS, Glaspy JA, Phelps ME, Hoh CK (1998) Accuracy of whole-body Fluorine-18-FDG PET for the detection of recurrent or metastatic breast carcinoma. J Nucl Med 39:431–435PubMed

Smith IC, Welch AE, Hutcheon AW, Miller ID, Payne S, Chilcott F, Waikar S, Whitaker T, Ah-See AK, Eremin O, Heys SD, Gilbert FJ, Sharp PF (2000) Positron emission tomography using ¹⁸FDG to predict the pathologic response of breast cancer to primary chemotherapy. J Clin Oncol 18:1676–1688PubMed

Schelling M, Avril N, Nahrig J, Kuhn W, Romer W, Sattler D, Werner M, Dose J, Janicke F, Graeff H, Schwaiger M (2000) Positron emission tomography using ¹⁸FDG for monitoring primary chemotherapy in breast cancer. J Clin Oncol 18:1689–1695PubMed

Loomus GN, Aneja P, Bota RA (1983) A case of peliosis hepatic in association with tamoxifen therapy. Am J Clin Pathol 80:881–883PubMed

Moffat DF, Oien KA, Dickson J, et al. (2000) Hepatocellular carcinoma after long-term tamoxifen therapy. Ann Oncol 11:1195–1196PubMedCrossRef

10.

Pinto HC, Baptista A, Camilo ME, de Costa EB, Valente A, de Moura MC (1995) Tamoxifen-associated steatohepatitis—report of three cases. J Hepatol 23:95–97PubMedCrossRef

11.

Storen EC, Hay JE, Kaur J, et al. (2000) Tamoxifen-induced submassive hepatic necrosis. Cancer J 6:58–60PubMed

12.

Oien KA, Moffat DF, Curry GW, Dickson J, Habeshaw T, Mills PR, MacSween RNM (1999) Cirrhosis with staetohepatitis after adjuvant tamoxifen. Lancet 353:36–37PubMedCrossRef

Title: Diffuse Desmoplastic Metastatic Breast Cancer Simulating Cirrhosis with Severe Portal Hypertension: A Case of “Pseudocirrhosis”
Authors: David A. Sass
Kenneth Clark
Dana Grzybicki
Mordechai Rabinovitz
Thomas A. Shaw-Stiffel
Publication date: 01-03-2007
Publisher: Kluwer Academic Publishers-Plenum Publishers
Published in: Digestive Diseases and Sciences / Issue 3/2007
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9332-9

ACC 2024 Congress Coverage

Heart Failure Video

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Diffuse Desmoplastic Metastatic Breast Cancer Simulating Cirrhosis with Severe Portal Hypertension: A Case of “Pseudocirrhosis”

Excerpt

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 3/2007

Effects of Combination Therapy with Direct Hemoperfusion Using Polymyxin B-Immobilized Fiber and Oral Vancomycin on Fulminant Pseudomembranous Colitis with Septic Shock

Colorectal Cancer Localization in Young Patients: Should We Expand the Screening Program?

The Role of Probiotics in Inflammatory Bowel Disease

Circulating Ghrelin in Patients with Gastric or Colorectal Cancer

High Proportions of Proinflammatory Bacteria on the Colonic Mucosa in a Young Patient with Ulcerative Colitis as Revealed by Cloning and Sequencing of 16S rRNA Genes

Retrospective Analysis of Esophageal Food Impaction: Differences in Etiology by Age and Gender

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

Incentivised to exercise

New intervention for STEMI-related cardiogenic shock

» View more highlights on the ACC 2024 congress hub page