Published in:
01-03-2007 | Case Report
Large Cell Lymphoma Presenting as a Flare of Colitis in a Patient with Common Variable Immune Deficiency
Authors:
Megan Dunnigan, Harris Yfantis, Aaron P. Rapoport, Keya Hosseinzadeh, Christopher D. Gocke, Raymond K. Cross
Published in:
Digestive Diseases and Sciences
|
Issue 3/2007
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Excerpt
Common variable immune deficiency (CVID) is one of the most common primary immunodeficiencies, with an incidence worldwide ranging from 1 in 25,000 to 1 in 100,000 [
1]. CVID is found equally among men and women and has a bimodal age distribution with peaks occurring between 1 and 5 years and between 18 and 25 years of age [
2]. The pathogenesis is not well understood; however, defects exist in B-cell differentiation [
3,
4], T-cell function and signaling [
5‐
7], and immunoglobulin secretion [
8]. The multiple immune defects present in CVID lead to a myriad of clinical symptoms including recurrent sinopulmonary infections, chronic lung disease, autoimmune diseases, liver and gastrointestinal disorders, lymphomas, and solid organ tumors [
4,
9,
10]. …
