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Digestive Diseases and Sciences
Published in: Digestive Diseases and Sciences 8/2006

01-08-2006 | Original Article

Nitric Oxide and Antioxidant Defense in Patients with Gastric Cancer

Authors: Yildiz Dincer, Tülay Akcay, Osman B. Tortum, Gülen Dogusoy

Published in: Digestive Diseases and Sciences | Issue 8/2006

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Abstract

In the present study, total nitrate and nitrite level (as end product of nitric oxide), superoxide dismutase activity, and glutathione peroxidase activity in leukocytes were determined in patients with gastric cancer, and the relationship between measured parameters and tumor grade were evaluated. Leukocyte nitrate and nitrite level was found to be increased and superoxide dismutase activity was found to be decreased in patients compared to controls. When the patient group was categorized, nitrate and nitrite level was found to be higher in patients with a high-grade tumor than in patients with a grade I tumor. We concluded that an increased level of leukocyte nitrate and nitrite is related to tumor grade in patients with gastric cancer; antioxidant activity is also impaired in these patients but it does not seem to be related to grade of tumor.
Literature
1.
Dreher D, Junod AF (1995) Role of oxygen free radicals in cancer development. Eur J Cancer 32:30–38CrossRef
2.
Feig DI, Reid TM, Loeb LA (1994) Reactive oxygen species in tumorigenesis. Cancer Res 54:1890–1894
3.
Halliwell B (1996) Oxidative stress, nutrition and health. Experimental strategies for optimization of nutritional antioxidant intake in humans. Free Radic Res 25:57–74PubMedCrossRef
4.
Weitzman SA, Gordon LI (1990) Inflammation and cancer:role of phagocyte-generated oxidants in carcinogenesis. Blood 76(4):654–663
5.
Ohshima H, Bartsch H (1994) Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mutat Res 305:253–264PubMed
6.
Mirvish SS (1995) Role of N-nitroso compounds (NOC) and N-nitrosation in etiology of gastric, esophageal, nasopharyngeal and bladder cancer and contribution to cancer of known exposures to NOC. Cancer Lett 93:17–48PubMedCrossRef
7.
Hood JD, Meininger CJ, Ziche M, Granger HJ (1998) VEGF upregulates ecNOS message, protein and NO production in human endothelial cells. Am J Physiol 274:H1054–H1058PubMed
8.
Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine. Oxford University Press, Oxford
9.
Miranda A, Janssen L, Bosman CB, Van DuijinN W, Ostendorp-Van de Ruit MM, Kubben FJGM, Griffioen G, Lamers CBHW, Han J, Van Krieken JM, Van de Velde CJH, Verspaget HW (2000) Superoxide dismutases in gastric and esophageal cancer and the prognostic impact in gastric cancer. Clin Cancer Res 6(8):3183–3192
10.
Tari A, Kodama K, Kurihara K, Fujihara M, Sumii K, Kajiyama G (2002) Does serum nitrite concentration reflect gastric carcinogenesis in Japanese helicobacter pylori-infected patients? Dig Dis Sci 47:100–106PubMedCrossRef
11.
Vahakangas K, Trivers GE, Plummer S, Hayes RB, Krokan H, Rowe M, Swartz RP, Yeager H, Harris JCC (1991) O6-Methylguanine DNA methyltransferase and uracil DNA glycosylase in human broncho-alveolar lavage cells and peripheral blood mononuclear cells from tobacco smokers and nonsmokers. Carcionogenesis 12(8):1389–1394CrossRef
12.
Bradford MM (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254PubMedCrossRef
13.
Tamir S, Burney S, Tannenbaum SR (1996) DNA damage bynitric oxide. Chem Res Toxicol 19:821–827CrossRef
14.
Jaiswall M, Larusso NF, Shapro RA, Billiar TR, Gores GJ (2001) Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes. Gastroenterology 120:190–199CrossRef
15.
Bakan E, Taysi S, Polat MF, Dalga S, Umudum Z, Bakan N, Gümüş M (2002) Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Jpn J Clin Oncol 32(5):162–166PubMedCrossRef
16.
Senger DR, Van de Water L, Brown LF, Nagy JA, Yeo KT, Yeo TK, Berse B, Jackman RW, Dvorak AM, Dvorak HF (1993) Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastas Rev 12:303–324CrossRef
17.
Eroğlu A, Demirci S, Ayyıldız A, Kocaoğlu H, Akbulut H, Akgül H, Elhan HA (1999) Serum concentrations of vascular endothelial growth factor and nitrite as an estimate of in vivo nitric oxide in patients with gastric cancer. Br J Cancer 80(10):1630–1634PubMedCrossRef
18.
Izutani R, Asano S, Imano M, Kuroda D, Kato M, Ohyanagi H (1998) Expression of manganase superoxide dismutase in esophageal and gastric cancers. J Gastroenterol 33(6):816–822PubMedCrossRef
19.
Eapen CE, Madesh M, Balasubramanian KA, Pulimood A, Mathan M, Ramakrishna BS (1998) Mucosal mitochondrial function and antioxidant defenses in patients with gasric carcinoma. Scand J Gastroentorol 33(9):975–981CrossRef
20.
Wei LK (1991) The clinical and laboratory studies of superoxide dismutase activity in the human whole blood with early gastric cancer. Free Radic Res Commun 12–13(Pt 2):759–760PubMedCrossRef
21.
Durak İ, Örmeci N, Akyol O, Canbolat O, Kavutçu M, Bülbül M (1994) Adenosine deaminase, 5'–nucleotidase, xanthine oxidase, superoxide dismutase, and catalase activities in gastric juice from patients with gastric cancer, ulcer, and atrophic gastritis. Dig Dis Sci 39:721–728PubMedCrossRef
22.
St. Clair DK, Oberley TD, Muse KE, St. Clair WH (1994) Expression of manganese superoxide dismutase promotes cellular differentiation. Free Radic Biol Med 16:275–282PubMedCrossRef
23.
Kiningham KK, St. Clair DK (1997) Overexpression of manganese superoxide dismutase selectively modulates the activity of jun-associated transcription factors in fibrosarcoma cells. Cancer Res 57:5265–5271PubMed
24.
25.
Grzelak A, Sosynski M, Bartosz G (2000) Inactivation of antioxidant enzymes by peroxynitrite. Scand J Clin Lab Invest 6(4):253–258CrossRef
26.
Dinçer Y, Alademir Z, Ilkova H, Akçay T (2002) Susceptibility of glutathione and glutathione-related antioxidant activity to hydrogen peroxide in patients with type 2 diabetes: effects of glycemic control,. Clin Biochem 35(4):297–301PubMedCrossRef
27.
Dinçer Y, Akçay T, Alademir Z, IIkova H (2002) Effect of oxidative stress on glutathione pathway in red blood cells from patients with IDDM. Metabolism 51(10):1360–1362PubMedCrossRef
28.
Pawlowicz Z, Zachara BA, Trafikowska U, Maciag A, Marchaluk E, Nowicki A (1991) Blood selenium concentrations and glutathione peroxidase activities in patients with breast cancer and with advanced gastrointestinal cancer. J Trace Elem Electrolytes Health Dis 5(4):275–277PubMed
Metadata
Title
Nitric Oxide and Antioxidant Defense in Patients with Gastric Cancer
Authors
Yildiz Dincer
Tülay Akcay
Osman B. Tortum
Gülen Dogusoy
Publication date
01-08-2006
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 8/2006
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-005-9021-0

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