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01-03-2009 | Research Paper

Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells

Authors: Vanity McMurtry, Ann-Marie Simeone, René Nieves-Alicea, Ana M. Tari

Published in: Clinical & Experimental Metastasis | Issue 3/2009

Abstract

In breast tumors, high levels of leptin have been associated with increased incidence of breast cancer metastasis. Breast cancer metastasis is directly associated with breast cancer cell invasion. However, whether leptin could augment breast cancer cell invasion is not known. Here we showed that leptin increased the invasiveness and the matrix metallo-proteinase-2 (MMP-2) activity of the MCF-7 breast cancer cell line. Leptin stimulated the phosphorylation of extracellular signals regulated kinases, signal transducers and activators of transcription 3 and Jun N-terminal kinases (JNK); however, only inhibition of JNK decreased leptin-mediated activation of MMP-2. Furthermore, inhibition of JNK suppressed leptin-mediated breast cancer cell invasion. Here we report the novel findings that leptin increased invasion of breast cancer cells by activating JNK, resulting in increased MMP-2 activity.

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Title: Leptin utilizes Jun N-terminal kinases to stimulate the invasion of MCF-7 breast cancer cells
Authors: Vanity McMurtry
Ann-Marie Simeone
René Nieves-Alicea
Ana M. Tari
Publication date: 01-03-2009
Publisher: Springer Netherlands
Published in: Clinical & Experimental Metastasis / Issue 3/2009
Print ISSN: 0262-0898
Electronic ISSN: 1573-7276
DOI: https://doi.org/10.1007/s10585-008-9231-x

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