Skip to main content
Top
Published in: Cardiovascular Drugs and Therapy 1/2018

01-02-2018 | ORIGINAL ARTICLE

Mind the Gap: Mismatches Between Clinicians and Patients in Heart Failure Medication Management

Authors: Ken Lee Chin, Marina Skiba, Christopher M. Reid, Andrew Tonkin, Ingrid Hopper, Justin A. Mariani, Danny Liew

Published in: Cardiovascular Drugs and Therapy | Issue 1/2018

Login to get access

Abstract

Purpose

Previous studies on the ‘treatment gap’ in patients with heart failure (HF) have focused either on prescribing or patients’ adherence to prescribed treatment. This study sought to determine whether or not recent initiatives to close the gap have also minimised any mismatches between physicians’ expectation of their patients’ medications, medications in the patients’ possession and their actual medication use.

Methods

A cross-sectional observational survey was conducted from December 2015 to June 2016 in The Alfred Hospital HF clinic in Melbourne, Australia. Patients were invited to participate if they had chronic HF (NYHA class II to IV), were aged ≥ 60 years, had no history of HF related hospitalisation within the past 6 months and were prescribed at least two HF medications.

Results

Of 123 eligible patients, 102 were recruited into the study. Beta-blockers, mineralocorticoid receptor antagonists, loop diuretics and statins were associated with the highest rates of mismatches of drugs and doses, ranging from 10 to 17%. Discrepancy of total daily doses was the most common type of mismatch. Overall, only 23.5% of the patients were taking the right drugs at the right doses as expected by their cardiologists/HF specialists.

Conclusions

Despite improved prescribers’ adherence to guideline-directed medical therapy, there remain considerable mismatches between prescribers’ expectation of patients’ HF medications, medications in patients’ possession and their actual medication use. Initiatives to improve this situation are urgently needed.
Literature
1.
go back to reference Komajda M. How well are we implementing evidence-based care? Eur J Heart Fail Suppl. 2009;8(Supplement 1):i39–44.CrossRef Komajda M. How well are we implementing evidence-based care? Eur J Heart Fail Suppl. 2009;8(Supplement 1):i39–44.CrossRef
2.
go back to reference Chin KL, Skiba M, Tonkin A, Reid CM, Liew D, Krum H, et al. The treatment gap in patients with chronic systolic heart failure: a systematic review of evidence-based prescribing in practice. Heart Fail Rev. 2016;21(6):675–97. Chin KL, Skiba M, Tonkin A, Reid CM, Liew D, Krum H, et al. The treatment gap in patients with chronic systolic heart failure: a systematic review of evidence-based prescribing in practice. Heart Fail Rev. 2016;21(6):675–97.
3.
go back to reference van der Wal MHL, Jaarsma T. Adherence in heart failure in the elderly: problem and possible solutions. Int J Cardiol. 2008;125(2):203–8.CrossRefPubMed van der Wal MHL, Jaarsma T. Adherence in heart failure in the elderly: problem and possible solutions. Int J Cardiol. 2008;125(2):203–8.CrossRefPubMed
4.
go back to reference Wu J-R, Corley DJ, Lennie TA, Moser DK. Effect of a medication-taking behavior feedback theory-based intervention on outcomes in patients with heart failure. J Card Fail. 2012;18(1):1–9.CrossRefPubMed Wu J-R, Corley DJ, Lennie TA, Moser DK. Effect of a medication-taking behavior feedback theory-based intervention on outcomes in patients with heart failure. J Card Fail. 2012;18(1):1–9.CrossRefPubMed
5.
go back to reference Bradi B, Granger, Ekman I, Granger CB, Ostergren J, Olofsson B, et al. Adherence to medication according to sex and age in the CHARM programme. Eur J Heart Fail. 2009;11:1092–8. Bradi B, Granger, Ekman I, Granger CB, Ostergren J, Olofsson B, et al. Adherence to medication according to sex and age in the CHARM programme. Eur J Heart Fail. 2009;11:1092–8.
6.
go back to reference Wu J-R, Moser DK, Lennie TA, Peden AR, Chen Y-C, Heo S. Factors influencing medication adherence in patients with heart failure. Heart Lung. 2008;37(1):8–16.CrossRefPubMed Wu J-R, Moser DK, Lennie TA, Peden AR, Chen Y-C, Heo S. Factors influencing medication adherence in patients with heart failure. Heart Lung. 2008;37(1):8–16.CrossRefPubMed
7.
go back to reference Modig S, Kristensson J, Ekwall AK, Hallberg IR, Midlöv P. Frail elderly patients in primary care—their medication knowledge and beliefs about prescribed medicines. Eur J Clin Pharmacol. 2009;65(2):151–5.CrossRefPubMed Modig S, Kristensson J, Ekwall AK, Hallberg IR, Midlöv P. Frail elderly patients in primary care—their medication knowledge and beliefs about prescribed medicines. Eur J Clin Pharmacol. 2009;65(2):151–5.CrossRefPubMed
8.
go back to reference Page K, Marwick TH, Lee R, Grenfell R, Abhayaratna WP, Aggarwal A, et al. A systematic approach to chronic heart failure care: a consensus statement. Med J Aust. 2014;201(3):146–50. Page K, Marwick TH, Lee R, Grenfell R, Abhayaratna WP, Aggarwal A, et al. A systematic approach to chronic heart failure care: a consensus statement. Med J Aust. 2014;201(3):146–50.
9.
go back to reference Chan Y-K, Tuttle C, Ball J. Teng T-HK, Ahamed Y, Carrington MJ, Stewart S. Current and projected burden of heart failure in the Australian adult population: a substantive but still ill-defined major health issue. BMC Health Serv Res. 2016;16(1):501.CrossRefPubMedPubMedCentral Chan Y-K, Tuttle C, Ball J. Teng T-HK, Ahamed Y, Carrington MJ, Stewart S. Current and projected burden of heart failure in the Australian adult population: a substantive but still ill-defined major health issue. BMC Health Serv Res. 2016;16(1):501.CrossRefPubMedPubMedCentral
10.
go back to reference McMurray JJV, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the heart failure association (HFA) of the ESC. Eur Heart J. 2012;33:1787–847. McMurray JJV, Adamopoulos S, Anker SD, Auricchio A, Böhm M, Dickstein K, et al. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the heart failure association (HFA) of the ESC. Eur Heart J. 2012;33:1787–847.
11.
go back to reference Braunwald E. Heart failure. J Am Coll Cardiol. 2013;1:1–20. Braunwald E. Heart failure. J Am Coll Cardiol. 2013;1:1–20.
12.
go back to reference Norton C, Georgiopoulou VV, Kalogeropoulos AP, Butler J. Epidemiology and cost of advanced heart failure. Prog Cardiovasc Dis. 2011;54(2):78–85.CrossRefPubMed Norton C, Georgiopoulou VV, Kalogeropoulos AP, Butler J. Epidemiology and cost of advanced heart failure. Prog Cardiovasc Dis. 2011;54(2):78–85.CrossRefPubMed
13.
go back to reference Rohde LE, Bertoldi EG, Goldraich L, Polanczyk CA. Cost-effectiveness of heart failure therapies. Nat Rev Cardiol. 2013;10(6):338–54.CrossRefPubMed Rohde LE, Bertoldi EG, Goldraich L, Polanczyk CA. Cost-effectiveness of heart failure therapies. Nat Rev Cardiol. 2013;10(6):338–54.CrossRefPubMed
14.
go back to reference Banka G, Heidenreich PA, Fonarow GC. Incremental cost-effectiveness of guideline-directed medical therapies for heart failure. J Am Coll Cardiol. 2013;61(13):1440–6.CrossRefPubMed Banka G, Heidenreich PA, Fonarow GC. Incremental cost-effectiveness of guideline-directed medical therapies for heart failure. J Am Coll Cardiol. 2013;61(13):1440–6.CrossRefPubMed
15.
go back to reference Cline C, Björck-Linné A, Israelsson B, Willenheimer R, Erhardt L. Non-compliance and knowledge of prescribed medication in elderly patients with heart failure. Eur J Heart Fail. 1999;1(2):145–9.CrossRefPubMed Cline C, Björck-Linné A, Israelsson B, Willenheimer R, Erhardt L. Non-compliance and knowledge of prescribed medication in elderly patients with heart failure. Eur J Heart Fail. 1999;1(2):145–9.CrossRefPubMed
16.
go back to reference Dunlay SM, Eveleth JM, Shah ND, McNallan SM, Roger VL. Medication adherence among community-dwelling patients with heart failure. Mayo Clin Proc. 2011;86(4):273–81.CrossRefPubMedPubMedCentral Dunlay SM, Eveleth JM, Shah ND, McNallan SM, Roger VL. Medication adherence among community-dwelling patients with heart failure. Mayo Clin Proc. 2011;86(4):273–81.CrossRefPubMedPubMedCentral
17.
go back to reference Komajda M, Anker SD, Cowie MR, Filippatos GS, Mengelle B, Ponikowski P, et al. Physicians’ adherence to guideline-recommended medications in heart failure with reduced ejection fraction: data from the QUALIFY global survey. Eur J Heart Fail. 2016;18(5):514–22. Komajda M, Anker SD, Cowie MR, Filippatos GS, Mengelle B, Ponikowski P, et al. Physicians’ adherence to guideline-recommended medications in heart failure with reduced ejection fraction: data from the QUALIFY global survey. Eur J Heart Fail. 2016;18(5):514–22.
18.
go back to reference Komajda M, Lapuerta P, Hermans N, Gonzalez-Juanatey JR, van Veldhuisen DJ, Erdmann E, et al. Adherence to guidelines is a predictor of outcome in chronic heart failure: the MAHLER survey. Eur Heart J. 2005;26(16):1653–9. Komajda M, Lapuerta P, Hermans N, Gonzalez-Juanatey JR, van Veldhuisen DJ, Erdmann E, et al. Adherence to guidelines is a predictor of outcome in chronic heart failure: the MAHLER survey. Eur Heart J. 2005;26(16):1653–9.
19.
go back to reference Granger BB, Swedberg K, Ekman I, Granger CB, Olofsson B, McMurray JJV, et al. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: doubleblind, randomised, controlled clinical trial. Lancet. 2005;366(9502):2005–11. Granger BB, Swedberg K, Ekman I, Granger CB, Olofsson B, McMurray JJV, et al. Adherence to candesartan and placebo and outcomes in chronic heart failure in the CHARM programme: doubleblind, randomised, controlled clinical trial. Lancet. 2005;366(9502):2005–11.
20.
go back to reference Ewen S, Baumgarten T, Rettig-Ewen V, Mahfoud F, Griese-Mammen N, Schulz M, et al. Analyses of drugs stored at home by elderly patients with chronic heart failure. Clin Res Cardiol. 2015;104(4):320–7. Ewen S, Baumgarten T, Rettig-Ewen V, Mahfoud F, Griese-Mammen N, Schulz M, et al. Analyses of drugs stored at home by elderly patients with chronic heart failure. Clin Res Cardiol. 2015;104(4):320–7.
21.
go back to reference Mattila M, Boehm L, Burke S, Kashyap A, Holschbach L, Miller T, et al. Nonprescription medication use in patients with heart failure: assessment methods, utilization patterns, and discrepancies with medical records. J Card Fail. 2013;19(12):811–5. Mattila M, Boehm L, Burke S, Kashyap A, Holschbach L, Miller T, et al. Nonprescription medication use in patients with heart failure: assessment methods, utilization patterns, and discrepancies with medical records. J Card Fail. 2013;19(12):811–5.
22.
go back to reference Vermeire E, Hearnshaw H, Van Royen P, Denekens J. Patient adherence to treatment: three decades of research. A comprehensive review. J Clin Pharm Ther. 2001;26(5):331–42.CrossRefPubMed Vermeire E, Hearnshaw H, Van Royen P, Denekens J. Patient adherence to treatment: three decades of research. A comprehensive review. J Clin Pharm Ther. 2001;26(5):331–42.CrossRefPubMed
23.
go back to reference Rose AJ, Fischer SH, Paasche-Orlow MK. Beyond medication reconciliation: the correct medication list. JAMA. 2017;317(20):2057–8.CrossRefPubMed Rose AJ, Fischer SH, Paasche-Orlow MK. Beyond medication reconciliation: the correct medication list. JAMA. 2017;317(20):2057–8.CrossRefPubMed
24.
go back to reference Milfred-Laforest SK, Chow SL, DiDomenico RJ, Dracup K, Ensor CR, Gattis-Stough W, et al. Clinical pharmacy services in heart failure: an opinion paper from the Heart Failure Society of America and American College of Clinical Pharmacy Cardiology Practice and Research Network. J Card Fail. 2013;19(5):354–69. Milfred-Laforest SK, Chow SL, DiDomenico RJ, Dracup K, Ensor CR, Gattis-Stough W, et al. Clinical pharmacy services in heart failure: an opinion paper from the Heart Failure Society of America and American College of Clinical Pharmacy Cardiology Practice and Research Network. J Card Fail. 2013;19(5):354–69.
25.
go back to reference Warden BA, Freels JP, Furuno JP, Mackay J. Pharmacy-managed program for providing education and discharge instructions for patients with heart failure. Am J Health Syst Pharm. 2014;71(2):134–9.CrossRefPubMed Warden BA, Freels JP, Furuno JP, Mackay J. Pharmacy-managed program for providing education and discharge instructions for patients with heart failure. Am J Health Syst Pharm. 2014;71(2):134–9.CrossRefPubMed
26.
go back to reference The Department of Health Australia. Medication management reviews. In, 2017. The Department of Health Australia. Medication management reviews. In, 2017.
27.
go back to reference Carter SR, Moles R, White L, Chen TF. Patients’ willingness to use a pharmacist-provided medication management service: the influence of outcome expectancies and communication efficacy. Res Soc Adm Pharm. 2012;8(6):487–98.CrossRef Carter SR, Moles R, White L, Chen TF. Patients’ willingness to use a pharmacist-provided medication management service: the influence of outcome expectancies and communication efficacy. Res Soc Adm Pharm. 2012;8(6):487–98.CrossRef
Metadata
Title
Mind the Gap: Mismatches Between Clinicians and Patients in Heart Failure Medication Management
Authors
Ken Lee Chin
Marina Skiba
Christopher M. Reid
Andrew Tonkin
Ingrid Hopper
Justin A. Mariani
Danny Liew
Publication date
01-02-2018
Publisher
Springer US
Published in
Cardiovascular Drugs and Therapy / Issue 1/2018
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-017-6768-4

Other articles of this Issue 1/2018

Cardiovascular Drugs and Therapy 1/2018 Go to the issue