Skip to main content
Top
Published in: Cardiovascular Drugs and Therapy 4/2015

01-08-2015 | ORIGINAL ARTICLE

Metabolic Syndrome: Does it Differ Between Women and Men?

Authors: Yogita Rochlani, Naga Venkata Pothineni, Jawahar L. Mehta

Published in: Cardiovascular Drugs and Therapy | Issue 4/2015

Login to get access

Abstract

Cardiovascular disease represents a massive healthcare burden worldwide. Gender differences in the pathophysiology, presentation and prognosis of cardiovascular disease have been described in the literature. Metabolic syndrome, characterized by a cluster of metabolic abnormalities is associated with increased risk for type 2 diabetes mellitus and atherosclerotic cardiovascular disease. With the global obesity epidemic, the prevalence of metabolic syndrome is rising rapidly in the developed as well as developing world. However, there is considerable variation in the prevalence based on geography, age, sex and, definition used for diagnosis. Data on gender related differences in metabolic syndrome is relatively scarce. Here, we aim to review the gender differences in epidemiology and pathophysiology of metabolic syndrome as well as its individual components. Knowledge of gender differences in metabolic syndrome can help design gender specific preventative and therapeutic strategies that will have a positive impact on overall population health.
Literature
1.
go back to reference Grundy SM, Hansen B, Smith Jr SC, Cleeman JI, Kahn RA, American Heart Association, National Heart, Lung, and Blood Institute, American Diabetes Association. Clinical management of metabolic syndrome: report of the American heart association/national heart, lung, and blood institute/American diabetes association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol. 2004;24(2):e19–24.CrossRefPubMed Grundy SM, Hansen B, Smith Jr SC, Cleeman JI, Kahn RA, American Heart Association, National Heart, Lung, and Blood Institute, American Diabetes Association. Clinical management of metabolic syndrome: report of the American heart association/national heart, lung, and blood institute/American diabetes association conference on scientific issues related to management. Arterioscler Thromb Vasc Biol. 2004;24(2):e19–24.CrossRefPubMed
2.
3.
go back to reference Wenger NK. Women and coronary heart disease: a century after herrick: understudied, underdiagnosed, and undertreated. Circulation. 2012;126(5):604–11.CrossRefPubMed Wenger NK. Women and coronary heart disease: a century after herrick: understudied, underdiagnosed, and undertreated. Circulation. 2012;126(5):604–11.CrossRefPubMed
4.
go back to reference Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–607.CrossRefPubMed Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988;37(12):1595–607.CrossRefPubMed
5.
go back to reference DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14(3):173–94.CrossRefPubMed DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14(3):173–94.CrossRefPubMed
6.
go back to reference Lemieux I, Pascot A, Couillard C, Lamarche B, Tchernof A, Almeras N, et al. Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation. 2000;102(2):179–84.CrossRefPubMed Lemieux I, Pascot A, Couillard C, Lamarche B, Tchernof A, Almeras N, et al. Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men? Circulation. 2000;102(2):179–84.CrossRefPubMed
7.
go back to reference Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149(7):1514–20.CrossRefPubMed Kaplan NM. The deadly quartet. Upper-body obesity, glucose intolerance, hypertriglyceridemia, and hypertension. Arch Intern Med. 1989;149(7):1514–20.CrossRefPubMed
8.
go back to reference Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683–9.CrossRefPubMed Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care. 2001;24(4):683–9.CrossRefPubMed
9.
go back to reference Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.CrossRefPubMed Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.CrossRefPubMed
10.
go back to reference Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285(19):2486–97.CrossRef Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA. 2001;285(19):2486–97.CrossRef
11.
go back to reference Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med. 2006;23(5):469–80.CrossRefPubMed Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabet Med. 2006;23(5):469–80.CrossRefPubMed
12.
go back to reference Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation. 2005;112(17):2735–52.CrossRefPubMed Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American heart association/national heart, lung, and blood institute scientific statement. Circulation. 2005;112(17):2735–52.CrossRefPubMed
13.
go back to reference Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National heart, Lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; and International association for the study of obesity. Circulation. 2009;120(16):1640–5.CrossRefPubMed Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; National heart, Lung, and blood institute; American heart association; World heart federation; International atherosclerosis society; and International association for the study of obesity. Circulation. 2009;120(16):1640–5.CrossRefPubMed
14.
go back to reference Lin CC, Liu CS, Li CI, Lin WY, Lai MM, Lin T, et al. The relation of metabolic syndrome according to five definitions to cardiovascular risk factors—a population-based study. BMC Public Health. 2009;9:484.PubMedCentralCrossRefPubMed Lin CC, Liu CS, Li CI, Lin WY, Lai MM, Lin T, et al. The relation of metabolic syndrome according to five definitions to cardiovascular risk factors—a population-based study. BMC Public Health. 2009;9:484.PubMedCentralCrossRefPubMed
15.
go back to reference Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United states, 2003–2006. Natl Health Stat Rep. 2009;13:1–7. Ervin RB. Prevalence of metabolic syndrome among adults 20 years of age and over, by sex, age, race and ethnicity, and body mass index: United states, 2003–2006. Natl Health Stat Rep. 2009;13:1–7.
16.
go back to reference Meigs JB, Wilson PW, Nathan DM, D’Agostino RBS, Williams K, Haffner SM. Prevalence and characteristics of the metabolic syndrome in the San Antonio heart and Framingham offspring studies. Diabetes. 2003;52(8):2160–7.CrossRefPubMed Meigs JB, Wilson PW, Nathan DM, D’Agostino RBS, Williams K, Haffner SM. Prevalence and characteristics of the metabolic syndrome in the San Antonio heart and Framingham offspring studies. Diabetes. 2003;52(8):2160–7.CrossRefPubMed
17.
go back to reference Mozumdar A, Liguori G. Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999–2006. Diabetes Care. 2011;34(1):216–9.PubMedCentralCrossRefPubMed Mozumdar A, Liguori G. Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999–2006. Diabetes Care. 2011;34(1):216–9.PubMedCentralCrossRefPubMed
18.
go back to reference Miller JM, Kaylor MB, Johannsson M, Bay C, Churilla JR. Prevalence of metabolic syndrome and individual criterion in US adolescents: 2001–2010 national health and nutrition examination survey. Metab Syndr Relat Disord. 2014;12(10):527–32.CrossRefPubMed Miller JM, Kaylor MB, Johannsson M, Bay C, Churilla JR. Prevalence of metabolic syndrome and individual criterion in US adolescents: 2001–2010 national health and nutrition examination survey. Metab Syndr Relat Disord. 2014;12(10):527–32.CrossRefPubMed
19.
go back to reference Loucks EB, Rehkopf DH, Thurston RC, Kawachi I. Socioeconomic disparities in metabolic syndrome differ by gender: evidence from NHANES III. Ann Epidemiol. 2007;17(1):19–26.CrossRefPubMed Loucks EB, Rehkopf DH, Thurston RC, Kawachi I. Socioeconomic disparities in metabolic syndrome differ by gender: evidence from NHANES III. Ann Epidemiol. 2007;17(1):19–26.CrossRefPubMed
20.
go back to reference Cherry CO, Serieux E, Didier M, Nuttal ME, Schuster RJ. Prevalence of risk factors for the metabolic syndrome in the middle income Caribbean nation of St. Lucia. Adv Prev Med. 2014;2014:501972.PubMedCentralCrossRefPubMed Cherry CO, Serieux E, Didier M, Nuttal ME, Schuster RJ. Prevalence of risk factors for the metabolic syndrome in the middle income Caribbean nation of St. Lucia. Adv Prev Med. 2014;2014:501972.PubMedCentralCrossRefPubMed
21.
go back to reference Ishii S, Tanaka T, Akishita M, Ouchi Y, Tuji T, Iijima K, et al. Metabolic syndrome, Sarcopenia and role of sex and age: cross-sectional analysis of Kashiwa cohort study. PLoS One. 2014;9(11), e112718.PubMedCentralCrossRefPubMed Ishii S, Tanaka T, Akishita M, Ouchi Y, Tuji T, Iijima K, et al. Metabolic syndrome, Sarcopenia and role of sex and age: cross-sectional analysis of Kashiwa cohort study. PLoS One. 2014;9(11), e112718.PubMedCentralCrossRefPubMed
22.
go back to reference Sobko T, Trindade D, Lao QX, Wong M, Io TK, Wa CK, et al. Men in Macau SAR have higher prevalence in metabolic syndrome and among related metabolic components: a cross-sectional Macau health survey. BMC Public Health. 2014;14:1065.PubMedCentralCrossRefPubMed Sobko T, Trindade D, Lao QX, Wong M, Io TK, Wa CK, et al. Men in Macau SAR have higher prevalence in metabolic syndrome and among related metabolic components: a cross-sectional Macau health survey. BMC Public Health. 2014;14:1065.PubMedCentralCrossRefPubMed
23.
go back to reference Yu S, Guo X, Yang H, Zheng L, Sun Y. An update on the prevalence of metabolic syndrome and its associated factors in rural northeast China. BMC Public Health. 2014;14:877, 2458-14-877. Yu S, Guo X, Yang H, Zheng L, Sun Y. An update on the prevalence of metabolic syndrome and its associated factors in rural northeast China. BMC Public Health. 2014;14:877, 2458-14-877.
24.
go back to reference Xi B, He D, Hu Y, Zhou D. Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: the china health and nutrition survey in 2009. Prev Med. 2013;57(6):867–71.PubMedCentralCrossRefPubMed Xi B, He D, Hu Y, Zhou D. Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: the china health and nutrition survey in 2009. Prev Med. 2013;57(6):867–71.PubMedCentralCrossRefPubMed
25.
go back to reference Mabry RM, Reeves MM, Eakin EG, Owen N. Gender differences in prevalence of the metabolic syndrome in gulf cooperation council countries: a systematic review. Diabet Med. 2010;27(5):593–7.CrossRefPubMed Mabry RM, Reeves MM, Eakin EG, Owen N. Gender differences in prevalence of the metabolic syndrome in gulf cooperation council countries: a systematic review. Diabet Med. 2010;27(5):593–7.CrossRefPubMed
26.
go back to reference Erem C, Hacihasanoglu A, Deger O, Topbas M, Hosver I, Ersoz HO, et al. Prevalence of metabolic syndrome and associated risk factors among Turkish adults: Trabzon MetS study. Endocrine. 2008;33(1):9–20.CrossRefPubMed Erem C, Hacihasanoglu A, Deger O, Topbas M, Hosver I, Ersoz HO, et al. Prevalence of metabolic syndrome and associated risk factors among Turkish adults: Trabzon MetS study. Endocrine. 2008;33(1):9–20.CrossRefPubMed
27.
go back to reference Athyros VG, Bouloukos VI, Pehlivanidis AN, Papageorgiou AA, Dionysopoulou SG, Symeonidis AN, et al. The prevalence of the metabolic syndrome in Greece: the MetS-Greece multicentre study. Diabetes Obes Metab. 2005;7(4):397–405.CrossRefPubMed Athyros VG, Bouloukos VI, Pehlivanidis AN, Papageorgiou AA, Dionysopoulou SG, Symeonidis AN, et al. The prevalence of the metabolic syndrome in Greece: the MetS-Greece multicentre study. Diabetes Obes Metab. 2005;7(4):397–405.CrossRefPubMed
28.
go back to reference Balkau B, Charles MA, Drivsholm T, Borch-Johnsen K, Wareham N, Yudkin JS, et al. Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome. Diabetes Metab. 2002;28(5):364–76.PubMed Balkau B, Charles MA, Drivsholm T, Borch-Johnsen K, Wareham N, Yudkin JS, et al. Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome. Diabetes Metab. 2002;28(5):364–76.PubMed
29.
go back to reference Dallongeville J, Cottel D, Arveiler D, Tauber JP, Bingham A, Wagner A, et al. The association of metabolic disorders with the metabolic syndrome is different in men and women. Ann Nutr Metab. 2004;48(1):43–50.CrossRefPubMed Dallongeville J, Cottel D, Arveiler D, Tauber JP, Bingham A, Wagner A, et al. The association of metabolic disorders with the metabolic syndrome is different in men and women. Ann Nutr Metab. 2004;48(1):43–50.CrossRefPubMed
30.
go back to reference Levine DA, Lewis CE, Williams OD, Safford MM, Liu K, Calhoun DA, et al. Geographic and demographic variability in 20-year hypertension incidence: the CARDIA study. Hypertension. 2011;57(1):39–47.PubMedCentralCrossRefPubMed Levine DA, Lewis CE, Williams OD, Safford MM, Liu K, Calhoun DA, et al. Geographic and demographic variability in 20-year hypertension incidence: the CARDIA study. Hypertension. 2011;57(1):39–47.PubMedCentralCrossRefPubMed
31.
go back to reference Ong KL, Tso AW, Lam KS, Cheung BM. Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension. 2008;51(4):1142–8.CrossRefPubMed Ong KL, Tso AW, Lam KS, Cheung BM. Gender difference in blood pressure control and cardiovascular risk factors in Americans with diagnosed hypertension. Hypertension. 2008;51(4):1142–8.CrossRefPubMed
32.
go back to reference Denton KM, Hilliard LM, Tare M. Sex-related differences in hypertension: seek and ye shall find. Hypertension. 2013;62(4):674–7.CrossRefPubMed Denton KM, Hilliard LM, Tare M. Sex-related differences in hypertension: seek and ye shall find. Hypertension. 2013;62(4):674–7.CrossRefPubMed
33.
go back to reference Rossi P, Frances Y, Kingwell BA, Ahimastos AA. Gender differences in artery wall biomechanical properties throughout life. J Hypertens. 2011;29(6):1023–33.CrossRefPubMed Rossi P, Frances Y, Kingwell BA, Ahimastos AA. Gender differences in artery wall biomechanical properties throughout life. J Hypertens. 2011;29(6):1023–33.CrossRefPubMed
34.
go back to reference Hilliard LM, Mirabito KM, Denton KM. Unmasking the potential of the angiotensin AT2 receptor as a therapeutic target in hypertension in men and women: what we know and what we still need to find out. Clin Exp Pharmacol Physiol. 2013;40(8):542–50.CrossRefPubMed Hilliard LM, Mirabito KM, Denton KM. Unmasking the potential of the angiotensin AT2 receptor as a therapeutic target in hypertension in men and women: what we know and what we still need to find out. Clin Exp Pharmacol Physiol. 2013;40(8):542–50.CrossRefPubMed
35.
go back to reference Harris MI, Eastman RC, Cowie CC, Flegal KM, Eberhardt MS. Comparison of diabetes diagnostic categories in the U.S. population according to the 1997 american diabetes association and 1980–1985 world health organization diagnostic criteria. Diabetes Care. 1997;20(12):1859–62.CrossRefPubMed Harris MI, Eastman RC, Cowie CC, Flegal KM, Eberhardt MS. Comparison of diabetes diagnostic categories in the U.S. population according to the 1997 american diabetes association and 1980–1985 world health organization diagnostic criteria. Diabetes Care. 1997;20(12):1859–62.CrossRefPubMed
36.
go back to reference Glucose tolerance and mortality: comparison of WHO and American diabetes association diagnostic criteria. The DECODE study group. European diabetes epidemiology group. Diabetes epidemiology: Collaborative analysis of diagnostic criteria in Europe. Lancet. 1999;354(9179):617–21. Glucose tolerance and mortality: comparison of WHO and American diabetes association diagnostic criteria. The DECODE study group. European diabetes epidemiology group. Diabetes epidemiology: Collaborative analysis of diagnostic criteria in Europe. Lancet. 1999;354(9179):617–21.
37.
go back to reference Unwin N, Shaw J, Zimmet P, Alberti KG. Impaired glucose tolerance and impaired fasting Glycaemia: the current status on definition and intervention. Diabet Med. 2002;19(9):708–23.CrossRefPubMed Unwin N, Shaw J, Zimmet P, Alberti KG. Impaired glucose tolerance and impaired fasting Glycaemia: the current status on definition and intervention. Diabet Med. 2002;19(9):708–23.CrossRefPubMed
38.
go back to reference Varlamov O, Bethea CL, Roberts Jr CT. Sex-specific differences in lipid and glucose metabolism. Front Endocrinol (Lausanne). 2015;5:241. Varlamov O, Bethea CL, Roberts Jr CT. Sex-specific differences in lipid and glucose metabolism. Front Endocrinol (Lausanne). 2015;5:241.
39.
go back to reference Aldhoon-Hainerova I, Zamrazilova H, Dusatkova L, Sedlackova B, Hlavaty P, Hill M, et al. Glucose homeostasis and insulin resistance: prevalence, gender differences and predictors in adolescents. Diabetol Metab Syndr. 2014;6(1):100. eCollection 2014.PubMedCentralCrossRefPubMed Aldhoon-Hainerova I, Zamrazilova H, Dusatkova L, Sedlackova B, Hlavaty P, Hill M, et al. Glucose homeostasis and insulin resistance: prevalence, gender differences and predictors in adolescents. Diabetol Metab Syndr. 2014;6(1):100. eCollection 2014.PubMedCentralCrossRefPubMed
40.
go back to reference Barrett-Connor E, Ferrara A. Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo study. Diabetes Care. 1998;21(8):1236–9.CrossRefPubMed Barrett-Connor E, Ferrara A. Isolated postchallenge hyperglycemia and the risk of fatal cardiovascular disease in older women and men. The Rancho Bernardo study. Diabetes Care. 1998;21(8):1236–9.CrossRefPubMed
41.
go back to reference Goff Jr DC, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, et al. Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation. 2006;113(5):647–56.CrossRefPubMed Goff Jr DC, Bertoni AG, Kramer H, Bonds D, Blumenthal RS, Tsai MY, et al. Dyslipidemia prevalence, treatment, and control in the Multi-Ethnic Study of Atherosclerosis (MESA): gender, ethnicity, and coronary artery calcium. Circulation. 2006;113(5):647–56.CrossRefPubMed
42.
go back to reference Johnson JL, Slentz CA, Duscha BD, Samsa GP, McCartney JS, Houmard JA, et al. Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis. 2004;176(2):371–7.CrossRefPubMed Johnson JL, Slentz CA, Duscha BD, Samsa GP, McCartney JS, Houmard JA, et al. Gender and racial differences in lipoprotein subclass distributions: the STRRIDE study. Atherosclerosis. 2004;176(2):371–7.CrossRefPubMed
43.
go back to reference Bittner V. Perspectives on dyslipidemia and coronary heart disease in women. J Am Coll Cardiol. 2005;46(9):1628–35.CrossRefPubMed Bittner V. Perspectives on dyslipidemia and coronary heart disease in women. J Am Coll Cardiol. 2005;46(9):1628–35.CrossRefPubMed
44.
go back to reference Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2014;384(9945):766–81.CrossRefPubMed Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the global burden of disease study 2013. Lancet. 2014;384(9945):766–81.CrossRefPubMed
45.
go back to reference Beydoun MA, Wang Y. Gender-ethnic disparity in BMI and waist circumference distribution shifts in US adults. Obesity (Silver Spring). 2009;17(1):169–76.CrossRef Beydoun MA, Wang Y. Gender-ethnic disparity in BMI and waist circumference distribution shifts in US adults. Obesity (Silver Spring). 2009;17(1):169–76.CrossRef
46.
go back to reference Garawi F, Devries K, Thorogood N, Uauy R. Global differences between women and men in the prevalence of obesity: is there an association with gender inequality? Eur J Clin Nutr. 2014;68(10):1101–6.CrossRefPubMed Garawi F, Devries K, Thorogood N, Uauy R. Global differences between women and men in the prevalence of obesity: is there an association with gender inequality? Eur J Clin Nutr. 2014;68(10):1101–6.CrossRefPubMed
47.
go back to reference Kahn HS, Bullard KM, Barker LE, Imperatore G. Differences between adiposity indicators for predicting all-cause mortality in a representative sample of United States non-elderly adults. PLoS One. 2012;7(11), e50428.PubMedCentralCrossRefPubMed Kahn HS, Bullard KM, Barker LE, Imperatore G. Differences between adiposity indicators for predicting all-cause mortality in a representative sample of United States non-elderly adults. PLoS One. 2012;7(11), e50428.PubMedCentralCrossRefPubMed
48.
go back to reference Pradhan AD. Sex differences in the metabolic syndrome: implications for cardiovascular health in women. Clin Chem. 2014;60(1):44–52.CrossRefPubMed Pradhan AD. Sex differences in the metabolic syndrome: implications for cardiovascular health in women. Clin Chem. 2014;60(1):44–52.CrossRefPubMed
49.
go back to reference Meyer MR, Clegg DJ, Prossnitz ER, Barton M. Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol (Oxf). 2011;203(1):259–69.CrossRef Meyer MR, Clegg DJ, Prossnitz ER, Barton M. Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors. Acta Physiol (Oxf). 2011;203(1):259–69.CrossRef
50.
go back to reference Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH, van der Schouw YT. Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epidemiol. 2011;40(1):189–207.CrossRefPubMed Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH, van der Schouw YT. Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies. Int J Epidemiol. 2011;40(1):189–207.CrossRefPubMed
51.
go back to reference Bhasin S, Jasjua GK, Pencina M, D’Agostino RS, Coviello AD, Vasan RS, et al. Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the Framingham heart study. Diabetes Care. 2011;34(11):2464–70.PubMedCentralCrossRefPubMed Bhasin S, Jasjua GK, Pencina M, D’Agostino RS, Coviello AD, Vasan RS, et al. Sex hormone-binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the Framingham heart study. Diabetes Care. 2011;34(11):2464–70.PubMedCentralCrossRefPubMed
52.
go back to reference Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: the study of women’s health across the nation. Arch Intern Med. 2008;168(14):1568–75.PubMedCentralCrossRefPubMed Janssen I, Powell LH, Crawford S, Lasley B, Sutton-Tyrrell K. Menopause and the metabolic syndrome: the study of women’s health across the nation. Arch Intern Med. 2008;168(14):1568–75.PubMedCentralCrossRefPubMed
53.
go back to reference Kupelian V, Hayes FJ, Link CL, Rosen R, McKinlay JB. Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab. 2008;93(9):3403–10.PubMedCentralCrossRefPubMed Kupelian V, Hayes FJ, Link CL, Rosen R, McKinlay JB. Inverse association of testosterone and the metabolic syndrome in men is consistent across race and ethnic groups. J Clin Endocrinol Metab. 2008;93(9):3403–10.PubMedCentralCrossRefPubMed
54.
go back to reference Duskova M, Pospisilova H. The role of non-aromatizable testosterone metabolite in metabolic pathways. Physiol Res. 2011;60(2):253–61.PubMed Duskova M, Pospisilova H. The role of non-aromatizable testosterone metabolite in metabolic pathways. Physiol Res. 2011;60(2):253–61.PubMed
55.
go back to reference Bjorntorp P. The origins and consequences of obesity. Diab Ciba Found Sym. 1996;201:68–80. discussion 80–9, 188–93. Bjorntorp P. The origins and consequences of obesity. Diab Ciba Found Sym. 1996;201:68–80. discussion 80–9, 188–93.
56.
go back to reference Kalyani RR, Franco M, Dobs AS, Ouyang P, Vaidya D, Bertoni A, et al. The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. J Clin Endocrinol Metab. 2009;94(11):4127–35.PubMedCentralCrossRefPubMed Kalyani RR, Franco M, Dobs AS, Ouyang P, Vaidya D, Bertoni A, et al. The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. J Clin Endocrinol Metab. 2009;94(11):4127–35.PubMedCentralCrossRefPubMed
57.
go back to reference Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Valkonen VP, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004;27(5):1036–41.CrossRefPubMed Laaksonen DE, Niskanen L, Punnonen K, Nyyssonen K, Tuomainen TP, Valkonen VP, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diabetes Care. 2004;27(5):1036–41.CrossRefPubMed
58.
go back to reference Li C, Ford ES, Li B, Giles WH, Liu S. Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care. 2010;33(7):1618–24.PubMedCentralCrossRefPubMed Li C, Ford ES, Li B, Giles WH, Liu S. Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care. 2010;33(7):1618–24.PubMedCentralCrossRefPubMed
59.
go back to reference Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295(11):1288–99.CrossRefPubMed Ding EL, Song Y, Malik VS, Liu S. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA. 2006;295(11):1288–99.CrossRefPubMed
60.
go back to reference Vikan T, Schirmer H, Njolstad I, Svartberg J. Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men. Eur J Endocrinol. 2010;162(4):747–54.CrossRefPubMed Vikan T, Schirmer H, Njolstad I, Svartberg J. Low testosterone and sex hormone-binding globulin levels and high estradiol levels are independent predictors of type 2 diabetes in men. Eur J Endocrinol. 2010;162(4):747–54.CrossRefPubMed
61.
go back to reference Ding EL, Song Y, Manson JE, Hunter DJ, Lee CC, Rifai N, Buring JE, Gaziano JM, Liu S. Sex Hormone–Binding globulin and risk of type 2 diabetes in women and men. N Engl J Med. 2009; 2015/02;361(12):1152–63. Ding EL, Song Y, Manson JE, Hunter DJ, Lee CC, Rifai N, Buring JE, Gaziano JM, Liu S. Sex Hormone–Binding globulin and risk of type 2 diabetes in women and men. N Engl J Med. 2009; 2015/02;361(12):1152–63.
62.
go back to reference Haring R, Volzke H, Spielhagen C, Nauck M, Wallaschofski H. The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome. Eur J Prev Cardiol. 2013;20(6):1061–8.CrossRefPubMed Haring R, Volzke H, Spielhagen C, Nauck M, Wallaschofski H. The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome. Eur J Prev Cardiol. 2013;20(6):1061–8.CrossRefPubMed
63.
go back to reference Daka B, Rosen T, Jansson PA, Larsson CA, Rastam L, Lindblad U. Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population. BMC Cardiovasc Disord. 2013;13:30.PubMedCentralCrossRefPubMed Daka B, Rosen T, Jansson PA, Larsson CA, Rastam L, Lindblad U. Low sex hormone-binding globulin is associated with hypertension: a cross-sectional study in a Swedish population. BMC Cardiovasc Disord. 2013;13:30.PubMedCentralCrossRefPubMed
64.
go back to reference Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA. 2002;288(3):321–33.CrossRefPubMed Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women’s health initiative randomized controlled trial. JAMA. 2002;288(3):321–33.CrossRefPubMed
65.
go back to reference Velez LM, Motta AB. Association between polycystic ovary syndrome and metabolic syndrome. Curr Med Chem. 2014;21(35):3999–4012.CrossRefPubMed Velez LM, Motta AB. Association between polycystic ovary syndrome and metabolic syndrome. Curr Med Chem. 2014;21(35):3999–4012.CrossRefPubMed
66.
go back to reference Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90(4):1929–35.CrossRefPubMed Apridonidze T, Essah PA, Iuorno MJ, Nestler JE. Prevalence and characteristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90(4):1929–35.CrossRefPubMed
67.
go back to reference Hillman JK, Johnson LN, Limaye M, Feldman RA, Sammel M, Dokras A. Black women with Polycystic Ovary Syndrome (PCOS) have increased risk for metabolic syndrome and cardiovascular disease compared with white women with PCOS [corrected]. Fertil Steril. 2014;101(2):530–5.CrossRefPubMed Hillman JK, Johnson LN, Limaye M, Feldman RA, Sammel M, Dokras A. Black women with Polycystic Ovary Syndrome (PCOS) have increased risk for metabolic syndrome and cardiovascular disease compared with white women with PCOS [corrected]. Fertil Steril. 2014;101(2):530–5.CrossRefPubMed
68.
go back to reference Essah PA, Nestler JE. The metabolic syndrome in polycystic ovary syndrome. J Endocrinol Investig. 2006;29(3):270–80.CrossRef Essah PA, Nestler JE. The metabolic syndrome in polycystic ovary syndrome. J Endocrinol Investig. 2006;29(3):270–80.CrossRef
69.
go back to reference Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56(14):1113–32.CrossRefPubMed Mottillo S, Filion KB, Genest J, Joseph L, Pilote L, Poirier P, et al. The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol. 2010;56(14):1113–32.CrossRefPubMed
70.
go back to reference Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care. 2005;28(7):1769–78.CrossRefPubMed Ford ES. Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of the evidence. Diabetes Care. 2005;28(7):1769–78.CrossRefPubMed
71.
go back to reference Kuk JL, Ardern CI. Age and sex differences in the clustering of metabolic syndrome factors: association with mortality risk. Diabetes Care. 2010;33(11):2457–61.PubMedCentralCrossRefPubMed Kuk JL, Ardern CI. Age and sex differences in the clustering of metabolic syndrome factors: association with mortality risk. Diabetes Care. 2010;33(11):2457–61.PubMedCentralCrossRefPubMed
72.
go back to reference Guize L, Thomas F, Pannier B, Bean K, Jego B, Benetos A. All-cause mortality associated with specific combinations of the metabolic syndrome according to recent definitions. Diabetes Care. 2007;30(9):2381–7.CrossRefPubMed Guize L, Thomas F, Pannier B, Bean K, Jego B, Benetos A. All-cause mortality associated with specific combinations of the metabolic syndrome according to recent definitions. Diabetes Care. 2007;30(9):2381–7.CrossRefPubMed
73.
go back to reference Hari P, Nerusu K, Veeranna V, Sudhakar R, Zalawadiya S, Ramesh K, et al. A gender-stratified comparative analysis of various definitions of metabolic syndrome and cardiovascular risk in a multiethnic U.S. population. Metab Syndr Relat Disord. 2012;10(1):47–55.PubMedCentralCrossRefPubMed Hari P, Nerusu K, Veeranna V, Sudhakar R, Zalawadiya S, Ramesh K, et al. A gender-stratified comparative analysis of various definitions of metabolic syndrome and cardiovascular risk in a multiethnic U.S. population. Metab Syndr Relat Disord. 2012;10(1):47–55.PubMedCentralCrossRefPubMed
74.
go back to reference Beltrán-Sánchez H, Harhay MO, Harhay MM, McElligott S. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999–2010. J Am Coll Cardiol. 2013;62(8):697–703.PubMedCentralCrossRefPubMed Beltrán-Sánchez H, Harhay MO, Harhay MM, McElligott S. Prevalence and trends of metabolic syndrome in the adult U.S. population, 1999–2010. J Am Coll Cardiol. 2013;62(8):697–703.PubMedCentralCrossRefPubMed
76.
go back to reference Heiss G, Snyder ML, Teng Y, Schneiderman N, Llabre MM, Cowie C, et al. Prevalence of metabolic syndrome among Hispanics/Latinos of diverse background: the Hispanic community health study/study of Latinos. Diabetes Care. 2014;37(8):2391–9.PubMedCentralCrossRefPubMed Heiss G, Snyder ML, Teng Y, Schneiderman N, Llabre MM, Cowie C, et al. Prevalence of metabolic syndrome among Hispanics/Latinos of diverse background: the Hispanic community health study/study of Latinos. Diabetes Care. 2014;37(8):2391–9.PubMedCentralCrossRefPubMed
77.
go back to reference Scuteri A, Najjar SS, Morrell CH, Lakatta EG, Cardiovascular Health Study. The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the cardiovascular health study. Diabetes Care. 2005;28(4):882–7.CrossRefPubMed Scuteri A, Najjar SS, Morrell CH, Lakatta EG, Cardiovascular Health Study. The metabolic syndrome in older individuals: prevalence and prediction of cardiovascular events: the cardiovascular health study. Diabetes Care. 2005;28(4):882–7.CrossRefPubMed
78.
go back to reference Ford ES, Li C, Zhao G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. J Diabetes. 2010;2(3):180–93.CrossRefPubMed Ford ES, Li C, Zhao G. Prevalence and correlates of metabolic syndrome based on a harmonious definition among adults in the US. J Diabetes. 2010;2(3):180–93.CrossRefPubMed
79.
go back to reference Yang JJ, Yoon HS, Lee SA, Choi JY, Song M, Han S, et al. Metabolic syndrome and sex-specific socio-economic disparities in childhood and adulthood: the Korea national health and nutrition examination surveys. Diabet Med. 2014;31(11):1399–409.CrossRefPubMed Yang JJ, Yoon HS, Lee SA, Choi JY, Song M, Han S, et al. Metabolic syndrome and sex-specific socio-economic disparities in childhood and adulthood: the Korea national health and nutrition examination surveys. Diabet Med. 2014;31(11):1399–409.CrossRefPubMed
80.
go back to reference Podang J, Sritara P, Narksawat K. Prevalence and factors associated with metabolic syndrome among a group of Thai working population: a cross sectional study. J Med Assoc Thai. 2013;96 Suppl 5:S33–41.PubMed Podang J, Sritara P, Narksawat K. Prevalence and factors associated with metabolic syndrome among a group of Thai working population: a cross sectional study. J Med Assoc Thai. 2013;96 Suppl 5:S33–41.PubMed
81.
go back to reference Deepa M, Farooq S, Datta M, Deepa R, Mohan V. Prevalence of metabolic syndrome using WHO, ATPIII and IDF definitions in Asian Indians: the Chennai urban rural epidemiology study (CURES-34). Diabetes Metab Res Rev. 2007;23(2):127–34.CrossRefPubMed Deepa M, Farooq S, Datta M, Deepa R, Mohan V. Prevalence of metabolic syndrome using WHO, ATPIII and IDF definitions in Asian Indians: the Chennai urban rural epidemiology study (CURES-34). Diabetes Metab Res Rev. 2007;23(2):127–34.CrossRefPubMed
82.
go back to reference Deedwania PC, Gupta R, Sharma KK, Achari V, Gupta B, Maheshwari A, et al. High prevalence of metabolic syndrome among urban subjects in India: a multisite study. Diabetes Metab Syndr. 2014;8(3):156–61.CrossRefPubMed Deedwania PC, Gupta R, Sharma KK, Achari V, Gupta B, Maheshwari A, et al. High prevalence of metabolic syndrome among urban subjects in India: a multisite study. Diabetes Metab Syndr. 2014;8(3):156–61.CrossRefPubMed
83.
go back to reference El Brini O, Akhouayri O, Gamal A, Mesfioui A, Benazzouz B. Prevalence of metabolic syndrome and its components based on a harmonious definition among adults in Morocco. Diabetes Metab Syndr Obes. 2014;7:341–6.PubMedCentralPubMed El Brini O, Akhouayri O, Gamal A, Mesfioui A, Benazzouz B. Prevalence of metabolic syndrome and its components based on a harmonious definition among adults in Morocco. Diabetes Metab Syndr Obes. 2014;7:341–6.PubMedCentralPubMed
84.
go back to reference Malik M, Razig SA. The prevalence of the metabolic syndrome among the multiethnic population of the United Arab Emirates: a report of a national survey. Metab Syndr Relat Disord. 2008;6(3):177–86.CrossRefPubMed Malik M, Razig SA. The prevalence of the metabolic syndrome among the multiethnic population of the United Arab Emirates: a report of a national survey. Metab Syndr Relat Disord. 2008;6(3):177–86.CrossRefPubMed
85.
go back to reference Al-Daghri NM, Alkharfy KM, Al-Attas OS, Khan N, Alfawaz HA, Alghanim SA, et al. Gender-dependent associations between socioeconomic status and metabolic syndrome: a cross-sectional study in the adult Saudi population. BMC Cardiovasc Disord. 2014;14:51.PubMedCentralCrossRefPubMed Al-Daghri NM, Alkharfy KM, Al-Attas OS, Khan N, Alfawaz HA, Alghanim SA, et al. Gender-dependent associations between socioeconomic status and metabolic syndrome: a cross-sectional study in the adult Saudi population. BMC Cardiovasc Disord. 2014;14:51.PubMedCentralCrossRefPubMed
86.
go back to reference Vernay M, Salanave B, de Peretti C, Druet C, Malon A, Deschamps V, et al. Metabolic syndrome and socioeconomic status in France: the French nutrition and health survey (ENNS, 2006–2007). Int J Public Health. 2013;58(6):855–64.CrossRefPubMed Vernay M, Salanave B, de Peretti C, Druet C, Malon A, Deschamps V, et al. Metabolic syndrome and socioeconomic status in France: the French nutrition and health survey (ENNS, 2006–2007). Int J Public Health. 2013;58(6):855–64.CrossRefPubMed
87.
go back to reference Maggi S, Noale M, Gallina P, Bianchi D, Marzari C, Limongi F, et al. Metabolic syndrome, diabetes, and cardiovascular disease in an elderly Caucasian cohort: the Italian longitudinal study on aging. J Gerontol A Biol Sci Med Sci. 2006;61(5):505–10.CrossRefPubMed Maggi S, Noale M, Gallina P, Bianchi D, Marzari C, Limongi F, et al. Metabolic syndrome, diabetes, and cardiovascular disease in an elderly Caucasian cohort: the Italian longitudinal study on aging. J Gerontol A Biol Sci Med Sci. 2006;61(5):505–10.CrossRefPubMed
Metadata
Title
Metabolic Syndrome: Does it Differ Between Women and Men?
Authors
Yogita Rochlani
Naga Venkata Pothineni
Jawahar L. Mehta
Publication date
01-08-2015
Publisher
Springer US
Published in
Cardiovascular Drugs and Therapy / Issue 4/2015
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI
https://doi.org/10.1007/s10557-015-6593-6

Other articles of this Issue 4/2015

Cardiovascular Drugs and Therapy 4/2015 Go to the issue