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Open Access 01-02-2013 | REVIEW ARTICLE

The Late Na⁺ Current - Origin and Pathophysiological Relevance

Authors: Antonio Zaza, Marcella Rocchetti

Published in: Cardiovascular Drugs and Therapy | Issue 1/2013

Excerpt

In excitable tissues, voltage-dependent Na⁺ current (I_Na) is best known for supporting autoregenerative depolarization and impulse propagation. Its transient component (I_NaT), which is large and terminated within several milliseconds by channel inactivation, fulfils this role. Nevertheless, I_Na also includes a smaller sustained component, i.e. one persisting during prolonged membrane depolarization, which contributes to repolarization course. Sustained I_Na implies slow or incomplete inactivation of a proportion of the Na⁺ channels activated during the action potential upstroke. Several mechanisms may underlie this phenomenon and contribute to arrhythmogenesis in different conditions. …

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Title: The Late Na+ Current - Origin and Pathophysiological Relevance
Authors: Antonio Zaza
Marcella Rocchetti
Publication date: 01-02-2013
Publisher: Springer US
Published in: Cardiovascular Drugs and Therapy / Issue 1/2013
Print ISSN: 0920-3206
Electronic ISSN: 1573-7241
DOI: https://doi.org/10.1007/s10557-012-6430-0

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