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Open Access 01-06-2012 | NON-THEMATIC REVIEW

Biological influence of Hakai in cancer: a 10-year review

Authors: Luis A. Aparicio, Manuel Valladares, Moisés Blanco, Guillermo Alonso, Angélica Figueroa

Published in: Cancer and Metastasis Reviews | Issue 1-2/2012

Abstract

In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in epithelial cells that is characterized as a potent tumor suppressor and is modulated during various processes including epithelial–mesenchymal transition. Recent data have provided evidences for novel biological functional role of Hakai during tumor progression and other diseases. Here, we will review the knowledge that has been accumulated since Hakai discovery 10 years ago and its implication in human cancer disease. We will highlight the different signaling pathways leading to the influence on Hakai and suggest its potential usefulness as therapeutic target for cancer.

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Title: Biological influence of Hakai in cancer: a 10-year review
Authors: Luis A. Aparicio
Manuel Valladares
Moisés Blanco
Guillermo Alonso
Angélica Figueroa
Publication date: 01-06-2012
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 1-2/2012
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-012-9348-x

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