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Published in:

01-06-2010

Inflammation-mediated promotion of invasion and metastasis

Authors: Graziella Solinas, Federica Marchesi, Cecilia Garlanda, Alberto Mantovani, Paola Allavena

Published in: Cancer and Metastasis Reviews | Issue 2/2010

Abstract

Inflammation has been suggested to represent the seventh hallmark of cancer. Myelomonocytic cells are a key component of cancer-related inflammation. Tumor-associated macrophages and their mediators affect key elements in the multistep process of invasion and metastasis, from interaction with the extracellular matrix to the construction of a pre-metastatic niche. Evidence indicating that inflammatory mediators affect genetic stability and cause persistent epigenetic alterations suggests that inflammatory components of the tumor microenvironment impacts on fundamental mechanisms responsible for the generation of metastatic variants. These results provide impetus for efforts aimed at translating cancer-related inflammation into diagnostic–prognostic markers and innovative therapeutic strategies.

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Chiodoni C, Colombo MP, Sangaletti S. Matricellular proteins: form homeostasis to inflammation, cancer and metastasis. Cancer Metastasis Reviews, in press (this issue).

Title: Inflammation-mediated promotion of invasion and metastasis
Authors: Graziella Solinas
Federica Marchesi
Cecilia Garlanda
Alberto Mantovani
Paola Allavena
Publication date: 01-06-2010
Publisher: Springer US
Published in: Cancer and Metastasis Reviews / Issue 2/2010
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI: https://doi.org/10.1007/s10555-010-9227-2

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