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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 2/2010

01-06-2010 | NON-THEMATIC REVIEW

Hereditary ovarian cancers: from BRCA mutations to clinical management. A modern appraisal

Authors: Andrea Tinelli, Antonio Malvasi, Giuseppe Leo, Daniele Vergara, Maurizio Pisanò, Mariangela Ciccarese, Vincenzo Emanuele Chiuri, Vito Lorusso

Published in: Cancer and Metastasis Reviews | Issue 2/2010

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Abstract

In the past few years, ovarian cancer research has focused increasingly on disease prevention; but an increasing number of women refer to gynecology and clinical genetics clinics with a family history of ovarian cancer and inherited familial mutations. The interest on the issue has increased also due to the identification of BReast CAncer1 (BRCA1) and BRCA2 genes mutations. The importance of recognizing the characteristics of hereditary ovarian cancer (HOC) and manage women at risk appropriately will provide more accurate care of the high-risk population. Women at risk can be identified by pedigree analysis and may receive counseling from interdisciplinary cancer genetics clinics, while those at high risk need to receive genetic testing. Risk calculation programs define risks and assist in decision-making in clinical options and genetic testing; they provide information on the risks of the disease, mutation status, and the use of genetic testing in the management of high-risk families. Furthermore, while a large number of surrogate preliminary markers have been identified, there are still limited studies on ovarian cancer genomics. Different options for risk management of HOC are available: surveillance, chemoprevention and prophylactic surgery. Surveillance in HOC high-risk patients is still not accurate. Chemoprevention is currently a controversial topic, because a number of major issues still need to be addressed in developing and testing agents for ovarian cancer chemoprevention. Prophylactic surgery has been shown to effectively decrease cancer risk, and it has the possibility to substantially reduce ovarian cancer mortality.
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Metadata
Title
Hereditary ovarian cancers: from BRCA mutations to clinical management. A modern appraisal
Authors
Andrea Tinelli
Antonio Malvasi
Giuseppe Leo
Daniele Vergara
Maurizio Pisanò
Mariangela Ciccarese
Vincenzo Emanuele Chiuri
Vito Lorusso
Publication date
01-06-2010
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 2/2010
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-010-9218-3

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