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Published in: The International Journal of Cardiovascular Imaging 3/2017

01-03-2017 | Original Paper

Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography

Authors: Carlos Collet, Yohei Sotomi, Rafael Cavalcante, Taku Asano, Yosuke Miyazaki, Erhan Tenekecioglu, Pieter Kistlaar, Yaping Zeng, Pannipa Suwanasson, Robbert J. de Winter, Koen Nieman, Patrick W. Serruys, Yoshinobu Onuma

Published in: The International Journal of Cardiovascular Imaging | Issue 3/2017

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Abstract

To establish the accuracy of coronary computed tomography angiography (CTA) for in-scaffold quantitative evaluation with optical coherence tomography (OCT) as a reference. The translucent backbone of the bioresorbable scaffold allow us to evaluate non-invasively the coronary lumen with coronary CTA. In the ABSORB first-in-man studies, coronary CTA was shown to be feasible for quantitative luminal assessment. Nevertheless, a comparison with an intravascular modality with higher resolution has never been performed. In the ABSORB Cohort B trial, 101 patient with non-complex lesions were treated with the fully biodegradable vascular scaffold. For this analysis, all patients who underwent coronary CTA at 18 months and OCT within ±180 days were included. Coronary CTA and OCT data were analysed at an independent core laboratory for quantitative cross-sectional luminal dimensions. The primary objective was the accuracy and precision of coronary CTA for in-scaffold minimal lumen area assessment, with OCT as a reference. Among the 101 patients of the ABSORB Cohort B trial, 35 underwent both OCT and coronary CTA. The feasibility of quantitative evaluation was 74%. In the scaffolded segment, coronary CTA underestimated minimal lumen area by 9.8% (accuracy 0.39 mm2, precision 1.0 mm2, 95% limits of agreement −1.71 to 2.50 mm2). A similar level of agreement was observed in the non-scaffolded segment. Compared to OCT, coronary CTA appears to be accurate for the estimation of in-scaffold luminal areas, with no difference compared to the non-scaffolded region.
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Metadata
Title
Accuracy of coronary computed tomography angiography for bioresorbable scaffold luminal investigation: a comparison with optical coherence tomography
Authors
Carlos Collet
Yohei Sotomi
Rafael Cavalcante
Taku Asano
Yosuke Miyazaki
Erhan Tenekecioglu
Pieter Kistlaar
Yaping Zeng
Pannipa Suwanasson
Robbert J. de Winter
Koen Nieman
Patrick W. Serruys
Yoshinobu Onuma
Publication date
01-03-2017
Publisher
Springer Netherlands
Published in
The International Journal of Cardiovascular Imaging / Issue 3/2017
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI
https://doi.org/10.1007/s10554-016-1018-6

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