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The International Journal of Cardiovascular Imaging

Published in:

01-03-2009 | Original Paper

A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research

Authors: Yuanbo Feng, Yi Xie, Huaijun Wang, Feng Chen, Yuxiang Ye, Lixin Jin, Guy Marchal, Yicheng Ni

Published in: The International Journal of Cardiovascular Imaging | Issue 3/2009

Abstract

We sought to obtain a rabbit myocardial infarction (MI) model for research with cardiac magnetic resonance imaging (cMRI) by overcoming a few technical difficulties. A novel endotracheal method was developed for intubation and ventilation. Fourteen rabbits were divided into group-1 (n = 8) with open-chest occlusion of left circumflex coronary artery and closed-chest reperfusion, and group-2 (n = 6) of non-ischemic control; and received ECG-triggered cMRI with delayed contrast enhancement (DE-cMRI) at a 1.5 T clinical scanner. The MI areas in group-1 were morphometrically compared between DE-cMRI and histochemically stained specimens. Left ventricular (LV) functions were compared between two groups.The success rate of intubation and reperfused MI was 8/8 and 6/8, respectively. Global and regional LV functions significantly decreased in group-1 as evidenced by significant hypokinesis of lateral LV-wall and wall thickening (P < 0.001). Mean MI-area was 19.41 ± 21.92% on DE-cMRI and 19.10 ± 22.61% with histochemical staining (r = 0.985). Global MI-volume was 17.92 ± 7.42% on DE-cMRI and 16.62 ± 7.16% with histochemistry (r = 0.994). The usefulness of this model was successfully tested for assessing a new contrast agent. The present rabbit MI model may offer a practical platform for more translational research using clinical MRI-facilities.

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Title: A modified rabbit model of reperfused myocardial infarction for cardiac MR imaging research
Authors: Yuanbo Feng
Yi Xie
Huaijun Wang
Feng Chen
Yuxiang Ye
Lixin Jin
Guy Marchal
Yicheng Ni
Publication date: 01-03-2009
Publisher: Springer Netherlands
Published in: The International Journal of Cardiovascular Imaging / Issue 3/2009
Print ISSN: 1569-5794
Electronic ISSN: 1875-8312
DOI: https://doi.org/10.1007/s10554-008-9393-2

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