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Cancer Causes & Control
Published in: Cancer Causes & Control 3/2019

01-03-2019 | Prostate Cancer | Original Paper

Pre-diagnostic carbohydrate intake and treatment failure after radical prostatectomy for early-stage prostate cancer

Authors: Kyeezu Kim, Angela Kong, Robert C. Flanigan, Marcus L. Quek, Courtney M. P. Hollowell, Patricia P. Vidal, Jefferey Branch, Leslie A. Dean, Virgilia Macias, Andre A. Kajadacsy-Balla, Marian L. Fitzgibbon, Daisy Cintron, Li Liu, Vincent L. Freeman

Published in: Cancer Causes & Control | Issue 3/2019

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Abstract

Purpose

An association between dietary carbohydrate intake and prostate cancer (PCa) prognosis is biologically plausible, but data are scarce. This prospective cohort study examined the relation between pre-diagnostic carbohydrate intake and treatment failure following radical prostatectomy for clinically early-stage PCa.

Methods

We identified 205 men awaiting radical prostatectomy and assessed their usual dietary intake of carbohydrates using the 110-item Block food frequency questionnaire. We also evaluated carbohydrate intake quality using a score based on the consumption of sugars relative to fiber, fat, and protein. Logistic regression analyzed their associations with the odds of treatment failure, defined as a detectable and rising serum prostate-specific antigen (PSA) or receiving androgen deprivation therapy (ADT) within 2 years.

Results

Sucrose consumption was associated with a higher odds and fiber consumption with a lower odds of ADT after accounting for age, race/ethnicity, body mass index, and tumor characteristics (odds ratio [OR] (95% confidence interval [CI]) 5.68 (1.71, 18.9) for 3rd vs. 1st sucrose tertile and 0.88 (0.81, 0.96) per gram of fiber/day, respectively). Increasing carbohydrate intake quality also associated with a lower odds of ADT (OR (95% CI) 0.78 (0.66, 0.92) per unit increase in score, range 0–12).

Conclusions

Pre-diagnostic dietary carbohydrate intake composition and quality influence the risk of primary treatment failure for early-stage PCa. Future studies incorporating molecular aspects of carbohydrate metabolism could clarify possible underlying mechanisms.
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Metadata
Title
Pre-diagnostic carbohydrate intake and treatment failure after radical prostatectomy for early-stage prostate cancer
Authors
Kyeezu Kim
Angela Kong
Robert C. Flanigan
Marcus L. Quek
Courtney M. P. Hollowell
Patricia P. Vidal
Jefferey Branch
Leslie A. Dean
Virgilia Macias
Andre A. Kajadacsy-Balla
Marian L. Fitzgibbon
Daisy Cintron
Li Liu
Vincent L. Freeman
Publication date
01-03-2019
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 3/2019
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-019-1134-4

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