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01-08-2019 | Human Papillomavirus | Original Paper

Soy and tea intake on cervical cancer risk: the Singapore Chinese Health Study

Authors: Proma Paul, Woon-Puay Koh, Aizhen Jin, Angelika Michel, Tim Waterboer, Michael Pawlita, Renwei Wang, Jian-Min Yuan, Lesley M. Butler

Published in: Cancer Causes & Control | Issue 8/2019

Abstract

Purpose

Soy isoflavones and tea catechins have immunomodulating and chemopreventive properties relevant for cervical carcinogenesis; however, there are limited epidemiologic data on the relationship of soy and tea consumption with cervical cancer risk. The aim of our study was to examine effects of soy and tea intake on cervical cancer risk among Singapore Chinese women.

Methods

The association between intake of soy and tea drinking and cervical cancer risk was investigated in a prospective, population-based cohort of 30,744 Chinese women in Singapore with an average 16.7 years of follow-up and 312 incident cervical cancer cases. Multivariable proportional hazard models were used to estimate hazard ratio (HR) and 95% confidence interval (CI) of cervical cancer associated with intake levels of soy and tea.

Results

High intake of soy alone was associated with a statistically borderline significant 20% reduced risk of cervical cancer (HR 0.80, 95% CI 0.61, 1.05) while green tea alone was not (HR 0.97, 95% CI: 0.76, 1.22). In stratified analysis, high intake of soy was associated with a statistically significant decrease in cervical cancer risk among green tea drinkers (HR 0.43; 95% CI 0.28, 0.69) but not among non-drinkers of green tea. The difference in the soy-cervical cancer risk association between green tea drinkers and non-drinkers was statistically significant (p for interaction = 0.004). This inverse association between soy intake and cervical cancer risk remained after further adjustment for human papillomavirus serostatus. Black tea consumption was not associated with cervical cancer risk.

Conclusions

These findings suggest that a protective effect of soy against cervical cancer development may depend on green tea constituents.

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Title: Soy and tea intake on cervical cancer risk: the Singapore Chinese Health Study
Authors: Proma Paul
Woon-Puay Koh
Aizhen Jin
Angelika Michel
Tim Waterboer
Michael Pawlita
Renwei Wang
Jian-Min Yuan
Lesley M. Butler
Publication date: 01-08-2019
Publisher: Springer International Publishing
Keywords: Human Papillomavirus
Herpes Simplex Type 2
Cervical Cancer
Cervical Cancer
Published in: Cancer Causes & Control / Issue 8/2019
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-019-01173-3

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