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01-01-2014 | Original paper

Do longer formula feeding and later introduction of solids increase risk for pediatric acute lymphoblastic leukemia?

Authors: Jeremy Michals Schraw, Yong Quan Dong, Mehmet Fatih Okcu, Michael E. Scheurer, Michele R. Forman

Published in: Cancer Causes & Control | Issue 1/2014

Abstract

Milk formula feeding can elevate insulin-like growth factor-1 levels, possibly impacting leukemogenesis. The intent of the current study is to examine the associations between infant feeding practices and age at introduction of solids on risk of childhood acute lymphoblastic leukemia (ALL). Incident cases of infant and childhood (aged ≤14 years) ALL (n = 142) were enrolled in a case–control study. Cases were frequency matched on age, sex, race, and ethnicity to two sets of controls (n = 284 total). Multivariable logistic regression was used to determine the association between infant feeding practices and age at the introduction of solids and the odds ratio of ALL. In adjusted multivariable analyses, each additional month of formula feeding was associated with a 1.17 (1.09–1.25) odds ratio; each additional month of age at introduction of solids was associated with a 1.18 (1.07–1.30) odds ratio. In this study, longer duration of formula feeding and later age at the introduction of solid foods were independently associated with increased risk of ALL. Additional studies are needed to address the factors influencing duration of formula feeding and delayed introduction of solids. The results support the potential role of energy balance in early life as a contributor to risk for pediatric acute lymphoblastic leukemia.

Hanley MB, Napolitano LA, McCune JM (2005) Growth hormone-induced stimulation of multilineage human hematopoiesis. Stem Cells 23(8):1170–1179. doi:10.1634/stemcells.2004-0322 PubMedCrossRef

Eshet R, Silbergeld A, Zaizov R, Stark B, Freud E, Laron Z, Shamai Y (2000) Decreased insulin-like growth factor-I receptor sites on circulating mononuclear cells from children with acute leukemia. Pediatr Hematol Oncol 17(3):253–260. doi:10.1080/088800100276433 PubMedCrossRef

Foster M, Montecino-Rodriguez E, Clark R, Dorshkind K (1998) Regulation of B and T cell development by anterior pituitary hormones. Cell Mol Life Sci 54(10):1076–1082PubMedCrossRef

Badr M, Hassan T, Tarhony SE, Metwally W (2010) Insulin-like growth factor-1 and childhood cancer risk. Oncol Lett 1(6):1055–1059. doi:10.3892/ol.2010.169 PubMedCentralPubMed

Sprehe MR, Barahmani N, Cao Y, Wang T, Forman MR, Bondy M, Okcu MF (2010) Comparison of birth weight corrected for gestational age and birth weight alone in prediction of development of childhood leukemia and central nervous system tumors. Pediatr Blood Cancer 54(2):242–249. doi:10.1002/pbc.22308 PubMedCentralPubMed

Milne E, Laurvick CL, Blair E, Bower C, de Klerk N (2007) Fetal growth and acute childhood leukemia: looking beyond birth weight. Am J Epidemiol 166(2):151–159. doi:10.1093/aje/kwm065 PubMedCrossRef

Schüz J, Kaatsch P, Kaletsch U, Meinert R, Michaelis J (1999) Association of childhood cancer with factors related to pregnancy and birth. Int J Epidemiol 28(4):631–639PubMedCrossRef

Callan AC, Milne E (2009) Involvement of the IGF system in fetal growth and childhood cancer: an overview of potential mechanisms. Cancer Causes Control: CCC 20(10):1783–1798. doi:10.1007/s10552-009-9378-z PubMedCrossRef

Madsen AL, Larnkjær A, Mølgaard C, Michaelsen KF (2011) IGF-I and IGFBP-3 in healthy 9 month old infants from the SKOT cohort: breastfeeding, diet, and later obesity. Growth Horm IGF Res: Off J Growth Horm Res Soc Int IGF Res Soc 21(4):199–204. doi:10.1016/j.ghir.2011.05.003 CrossRef

10.

Ong KK, Langkamp M, Ranke MB, Whitehead K, Hughes IA, Acerini CL, Dunger DB (2009) Insulin-like growth factor I concentrations in infancy predict differential gains in body length and adiposity: the Cambridge Baby Growth Study. Am J Clin Nutr 90(1):156–161. doi:10.3945/ajcn.2008.27408 PubMedCrossRef

11.

Socha P, Grote V, Gruszfeld D, Janas R, Demmelmair H, Closa-Monasterolo R, Subías JE, Scaglioni S, Verduci E, Dain E, Langhendries JP, Perrin E, Koletzko B, Group ECOTS (2011) Milk protein intake, the metabolic-endocrine response, and growth in infancy: data from a randomized clinical trial. Am J Clin Nutr 94(6 Suppl):1776S–1784S. doi:10.3945/ajcn.110.000596 PubMedCrossRef

12.

Kwan ML, Buffler PA, Abrams B, Kiley VA (2004) Breastfeeding and the risk of childhood leukemia: a meta-analysis. Public Health Rep 119(6):521–535. doi:10.1016/j.phr.2004.09.002 PubMedCentralPubMedCrossRef

13.

Martin RM, Gunnell D, Owen CG, Smith GD (2005) Breast-feeding and childhood cancer: a systematic review with metaanalysis. Int J Cancer J Int du Cancer 117(6):1020–1031. doi:10.1002/ijc.21274 CrossRef

14.

Wijndaele K, Lakshman R, Landsbaugh JR, Ong KK, Ogilvie D (2009) Determinants of early weaning and use of unmodified cow’s milk in infants: a systematic review. J Am Diet Assoc 109(12):2017–2028. doi:10.1016/j.jada.2009.09.003 PubMedCrossRef

15.

Scott JA, Binns CW, Graham KI, Oddy WH (2009) Predictors of the early introduction of solid foods in infants: results of a cohort study. BMC Pediatr 9:60. doi:10.1186/1471-2431-9-60 PubMedCentralPubMedCrossRef

16.

Smith MA, Ries LAG, Gurney JG, Ross JA (1999) Leukemia. In: Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL (eds) Cancer incidence and survival among children and adolescents, 1975–1995, National Cancer Institute, SEER Program. NIH Pub. No 99-4649. Bethesda, MD

17.

Savino F, Fissore MF, Grassino EC, Nanni GE, Oggero R, Silvestro L (2005) Ghrelin, leptin and IGF-I levels in breast-fed and formula-fed infants in the first years of life. Acta Paediatr (Oslo, Norway: 1992) 94(5):531–537. doi:10.1080/08035250510027642 CrossRef

18.

Hoppe C, Udam TR, Lauritzen L, Mølgaard C, Juul A, Michaelsen KF (2004) Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-y-old Danish children. Am J Clin Nutr 80(2):447–452PubMed

19.

Davidsson J, Lilljebjörn H, Andersson A, Veerla S, Heldrup J, Behrendtz M, Fioretos T, Johansson B (2009) The DNA methylome of pediatric acute lymphoblastic leukemia. Hum Mol Genet 18(21):4054–4065. doi:10.1093/hmg/ddp354 PubMedCrossRef

20.

Kuang SQ, Tong WG, Yang H, Lin W, Lee MK, Fang ZH, Wei Y, Jelinek J, Issa JP, Garcia-Manero G (2008) Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia. Leukemia 22(8):1529–1538. doi:10.1038/leu.2008.130 PubMedCrossRef

21.

Vilas-Zornoza A, Agirre X, Martín-Palanco V, Martín-Subero JI, San José-Eneriz E, Garate L, Álvarez S, Miranda E, Rodríguez-Otero P, Rifón J, Torres A, Calasanz MJ, Cruz Cigudosa J, Román-Gómez J, Prósper F (2011) Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. PLoS ONE 6(2):e17012. doi:10.1371/journal.pone.0017012 PubMedCentralPubMedCrossRef

22.

Wong IH, Ng MH, Huang DP, Lee JC (2000) Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications. Blood 95(6):1942–1949PubMed

23.

Mugambi MN, Musekiwa A, Lombard M, Young T, Blaauw R (2012) Synbiotics, probiotics or prebiotics in infant formula for full term infants: a systematic review. Nutr J 11:81. doi:10.1186/1475-2891-11-81 PubMedCentralPubMedCrossRef

24.

Carvalho RS, Michail S, Ashai-Khan F, Mezoff AG (2008) An update on pediatric gastroenterology and nutrition: a review of some recent advances. Curr Probl Pediatr Adolesc Health Care 38(7):204–228. doi:10.1016/j.cppeds.2008.06.002 PubMedCrossRef

25.

Heird WC (2007) Progress in promoting breast-feeding, combating malnutrition, and composition and use of infant formula, 1981–2006. J Nutr 137(2):499S–502SPubMed

26.

Grzeskowiak L, Gronlund MM, Beckmann C, Salminen S, von Berg A, Isolauri E (2012) The impact of perinatal probiotic intervention on gut microbiota: double-blind placebo-controlled trials in Finland and Germany. Anaerobe 18(1):7–13. doi:10.1016/j.anaerobe.2011.09.006 PubMedCrossRef

27.

American Academy of Pediatrics (2012) Breastfeeding and the use of human milk. Pediatrics 129(3):e827–e841. doi:10.1542/peds.2011-3552 CrossRef

28.

Altinkaynak S, Selimoglu MA, Turgut A, Kilicaslan B, Ertekin V (2006) Breast-feeding duration and childhood acute leukemia and lymphomas in a sample of Turkish children. J Pediatr Gastroenterol Nutr 42(5):568–572. doi:10.1097/01.mpg.0000215309.93911.84 PubMedCrossRef

29.

Bener A, Denic S, Galadari S (2001) Longer breast-feeding and protection against childhood leukaemia and lymphomas. Eur J Cancer 37(2):234–238PubMedCrossRef

30.

Infante-Rivard C, Fortier I, Olson E (2000) Markers of infection, breast-feeding and childhood acute lymphoblastic leukaemia. Br J Cancer 83(11):1559–1564. doi:10.1054/bjoc 2000.1495PubMedCentralPubMedCrossRef

31.

Perrillat F, Clavel J, Auclerc MF, Baruchel A, Leverger G, Nelken B, Philippe N, Schaison G, Sommelet D, Vilmer E, Hémon D (2002) Day-care, early common infections and childhood acute leukaemia: a multicentre French case-control study. Br J Cancer 86(7):1064–1069. doi:10.1038/sj.bjc.6600091 PubMedCentralPubMedCrossRef

32.

Rudant J, Orsi L, Menegaux F, Petit A, Baruchel A, Bertrand Y, Lambilliotte A, Robert A, Michel G, Margueritte G, Tandonnet J, Mechinaud F, Bordigoni P, Hémon D, Clavel J (2010) Childhood acute leukemia, early common infections, and allergy: the ESCALE study. Am J Epidemiol 172(9):1015–1027. doi:10.1093/aje/kwq233 PubMedCrossRef

33.

Shu XO, Linet MS, Steinbuch M, Wen WQ, Buckley JD, Neglia JP, Potter JD, Reaman GH, Robison LL (1999) Breast-feeding and risk of childhood acute leukemia. J Natl Cancer Inst 91(20):1765–1772PubMedCrossRef

34.

Flores-Lujano J, Perez-Saldivar ML, Fuentes-Pananá EM, Gorodezky C, Bernaldez-Rios R, Del Campo-Martinez MA, Martinez-Avalos A, Medina-Sanson A, Paredes-Aguilera R, De Diego-Flores Chapa J, Bolea-Murga V, Rodriguez-Zepeda MC, Rivera-Luna R, Palomo-Colli MA, Romero-Guzman L, Perez-Vera P, Alvarado-Ibarra M, Salamanca-Gómez F, Fajardo-Gutierrez A, Mejía-Aranguré JM (2009) Breastfeeding and early infection in the aetiology of childhood leukaemia in down syndrome. Br J Cancer 101(5):860–864. doi:10.1038/sj.bjc.6605244 PubMedCentralPubMedCrossRef

35.

Jourdan-Da Silva N, Perel Y, Méchinaud F, Plouvier E, Gandemer V, Lutz P, Vannier JP, Lamagnére JL, Margueritte G, Boutard P, Robert A, Armari C, Munzer M, Millot F, De Lumley L, Berthou C, Rialland X, Pautard B, Hémon D, Clavel J (2004) Infectious diseases in the first year of life, perinatal characteristics and childhood acute leukaemia. Br J Cancer 90(1):139–145. doi:10.1038/sj.bjc.6601384 PubMedCentralPubMedCrossRef

36.

Kwan ML, Buffler PA, Wiemels JL, Metayer C, Selvin S, Ducore JM, Block G (2005) Breastfeeding patterns and risk of childhood acute lymphoblastic leukaemia. Br J Cancer 93(3):379–384. doi:10.1038/sj.bjc.6602706 PubMedCentralPubMedCrossRef

37.

McKinney PA, Cartwright RA, Saiu JM, Mann JR, Stiller CA, Draper GJ, Hartley AL, Hopton PA, Birch JM, Waterhouse JA (1987) The inter-regional epidemiological study of childhood cancer (IRESCC): a case control study of aetiological factors in leukaemia and lymphoma. Arch Dis Child 62(3):279–287PubMedCrossRef

38.

Petridou E, Trichopoulos D, Kalapothaki V, Pourtsidis A, Kogevinas M, Kalmanti M, Koliouskas D, Kosmidis H, Panagiotou JP, Piperopoulou F, Tzortzatou F (1997) The risk profile of childhood leukaemia in Greece: a nationwide case-control study. Br J Cancer 76(9):1241–1247PubMedCentralPubMedCrossRef

39.

Greaves MF (1988) Speculations on the cause of childhood acute lymphoblastic leukemia. Leukemia 2(2):120–125PubMed

40.

Milne E, Royle JA, de Klerk NH, Blair E, Bailey H, Cole C, Attia J, Scott RJ, Armstrong BK (2009) Fetal growth and risk of childhood acute lymphoblastic leukemia: results from an Australian case-control study. Am J Epidemiol 170(2):221–228. doi:10.1093/aje/kwp117 PubMedCrossRef

41.

Hjalgrim LL, Rostgaard K, Hjalgrim H, Westergaard T, Thomassen H, Forestier E, Gustafsson G, Kristinsson J, Melbye M, Schmiegelow K (2004) Birth weight and risk for childhood leukemia in Denmark, Sweden, Norway, and Iceland. J Natl Cancer Inst 96(20):1549–1556. doi:10.1093/jnci/djh287 PubMedCrossRef

42.

Blatt J (2000) IGF1 and leukemia. Pediatr Hematol Oncol 17(3):199–201. doi:10.1080/088800100276361 PubMedCrossRef

43.

Ross JA, Perentesis JP, Robison LL, Davies SM (1996) Big babies and infant leukemia: a role for insulin-like growth factor-1? Cancer Causes Control: CCC 7(5):553–559PubMedCrossRef

44.

Campleman SL (2004) Childhood cancer in California 1988 to 1999 volume I: birth to age 14

45.

Linabery AM, Ross JA (2008) Trends in childhood cancer incidence in the U.S. (1992-2004). Cancer 112(2):416–432. doi:10.1002/cncr.23169 PubMedCrossRef

46.

Smith A, Lightfoot T, Simpson J, Roman E (2009) Birth weight, sex and childhood cancer: a report from the United Kingdom Childhood Cancer Study. Cancer Epidemiol 33(5):363–367. doi:10.1016/j.canep.2009.10.012 PubMedCrossRef

47.

Diamantaras AA, Dessypris N, Sergentanis TN, Ntouvelis E, Athanasiadou-Piperopoulou F, Baka M, Fragandrea I, Moschovi M, Polychronopoulou S, Stiakaki E, Panagiotakos D, Petridou E (2013) Nutrition in early life and risk of childhood leukemia: a case-control study in Greece. Cancer Causes Control: CCC 24(1):117–124. doi:10.1007/s10552-012-0097-5 PubMedCrossRef

Title: Do longer formula feeding and later introduction of solids increase risk for pediatric acute lymphoblastic leukemia?
Authors: Jeremy Michals Schraw
Yong Quan Dong
Mehmet Fatih Okcu
Michael E. Scheurer
Michele R. Forman
Publication date: 01-01-2014
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 1/2014
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-013-0309-7

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