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Cancer Causes & Control
Published in: Cancer Causes & Control 1/2013

01-01-2013 | Original paper

Nutrition in early life and risk of childhood leukemia: a case–control study in Greece

Authors: Andreas-Antonios Diamantaras, Nick Dessypris, Theodoros N. Sergentanis, Evangelos Ntouvelis, Fani Athanasiadou-Piperopoulou, Margarita Baka, Ioanna Fragandrea, Maria Moschovi, Sofia Polychronopoulou, Eftichia Stiakaki, Demosthenes Panagiotakos, Eleni Petridou

Published in: Cancer Causes & Control | Issue 1/2013

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Abstract

Purpose

There is a paucity of findings concerning the role of diet in childhood leukemogenesis, whereas the results are equivocal and the studies heterogeneous with regard to food items examined. This case–control study investigates the association of childhood leukemia with food groups, macronutrient consumption, total energy intake and adherence to Mediterranean diet among children aged 5–14 years in Greece.

Methods

A total of 139 consecutive, incident leukemia cases out of which 121 were acute lymphoblastic leukemia were derived from the Nationwide Registry for Childhood Hematological Malignancies along with one : one age- and gender-matched hospital controls. Information on socio-demographic, maternal and child variables and dietary habits was obtained through in-person interviews with the guardians/children. Multiple logistic regression was performed with adjustment for birth weight and possible confounding variables.

Results

Higher consumption of added lipids was associated with an increased risk of childhood leukemia, whereas consumption of milk and dairy products with reduced risk. From the macronutrient analysis, a borderline trend linking high protein intake with reduced childhood leukemia risk was observed.

Conclusion

Consumption of milk and dairy products in the first year of life may protect against childhood leukemia possibly through vitamin D actions, while added lipids may increase the risk through various mechanisms. These results offer a holistic evaluation of children’s nutrition and suggest that dietary habits in the early years of life may contribute to the prevention of childhood leukemia.
Appendix
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Metadata
Title
Nutrition in early life and risk of childhood leukemia: a case–control study in Greece
Authors
Andreas-Antonios Diamantaras
Nick Dessypris
Theodoros N. Sergentanis
Evangelos Ntouvelis
Fani Athanasiadou-Piperopoulou
Margarita Baka
Ioanna Fragandrea
Maria Moschovi
Sofia Polychronopoulou
Eftichia Stiakaki
Demosthenes Panagiotakos
Eleni Petridou
Publication date
01-01-2013
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 1/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-012-0097-5

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