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Cancer Causes & Control
Published in: Cancer Causes & Control 5/2013

01-05-2013 | Original paper

Anthropometric factors, physical activity, and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women: a case–control study

Authors: Masaaki Kawai, Yoichiro Kakugawa, Yoshikazu Nishino, Yohei Hamanaka, Noriaki Ohuchi, Yuko Minami

Published in: Cancer Causes & Control | Issue 5/2013

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Abstract

Purpose

The associations between anthropometric factors, physical activity (PA), and breast cancer risk in terms of estrogen-receptor/progesterone-receptor (ER/PgR) status have been unclear in Japanese women. This case–control study was designed to evaluate these associations.

Methods

From among female patients aged 30 years and over admitted to a single hospital in Japan between 1997 and 2009, 1,017 breast cancer cases (538ER+/PgR+, 125ER+/PgR−, 23 ER−/PgR+, 249 ER−/PgR−, and 82 missing) and 2,902 controls were selected. Height, weight, body mass index (BMI) (kg/m2), and time spent exercising (hours/week) were assessed using a self-administered questionnaire. Polytomous logistic regression analysis and tests for heterogeneity across ER+/PgR+ and ER−/PgR− were conducted.

Results

Higher BMI was associated with a higher risk of ER+/PgR+ cancer among women overall [odds ratio (OR) = 2.41, 95 % confidence interval (CI) 1.37–4.23 for BMI ≥30.0; P trend = 0.0001] and postmenopausal women (OR = 6.24, 95 % CI 2.68–14.53 for BMI ≥30.0; P trend < 0.0001). A longer time spent exercising (more than 5 h/week) showed a decreased risk for any type of breast cancer among overall and pre- and postmenopausal women, although this did not reach statistical significance. Height was not associated with any risk.

Conclusions

Higher BMI is associated with an increased risk of ER+/PgR+ cancer among women overall and postmenopausal women. PA might be associated with a decreased risk of any type. To prevent breast cancer, weight control and PA are important.
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Metadata
Title
Anthropometric factors, physical activity, and breast cancer risk in relation to hormone receptor and menopausal status in Japanese women: a case–control study
Authors
Masaaki Kawai
Yoichiro Kakugawa
Yoshikazu Nishino
Yohei Hamanaka
Noriaki Ohuchi
Yuko Minami
Publication date
01-05-2013
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 5/2013
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-013-0181-5

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