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Cancer Causes & Control
Published in: Cancer Causes & Control 11/2010

01-11-2010 | Original paper

Leisure-time physical activity and breast cancer risk by hormone receptor status: effective life periods and exercise intensity

Published in: Cancer Causes & Control | Issue 11/2010

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Abstract

Objective

Physical activity may decrease breast cancer risk. However, it is unclear what intensity of exercise and during which life periods this effect on decreasing risk is efficiently expressed, and whether the associations differ by the estrogen-/progesterone- receptor (ER/PR) status of tumors. We investigated associations between age- and intensity-specific leisure-time physical activity and ER/PR-defined breast cancer risk.

Methods

We conducted a hospital-based case–control study in Nagano, Japan. Subjects were 405 cases newly diagnosed (>99% known ER/PR) from 2001 to 2005, who were age-/area-matched with 405 controls. Activity was assessed with a self-reported questionnaire which considered intensity level (moderate and/or strenuous) at different ages (at 12 and 20 years, and in the previous 5 years). Odds ratios (ORs) and 95% confidence intervals were calculated using logistic regression.

Results

Strenuous but not moderate physical activity at age 12 was inversely associated with pre- and postmenopausal breast cancer risk across ER/PR subtypes [overall OR≥5 days/week vs. none = 0.24 (0.14–0.43)]. Moderate physical activity in the previous 5 years was significantly associated with a decrease in risk for postmenopausal ER + PR + tumors only [OR≥1 day/week vs. none = 0.35 (0.18–0.67)].

Conclusion

Strenuous activity in teens and moderate activity after menopause may contribute to a reduction in breast cancer risk.
Appendix
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Metadata
Title
Leisure-time physical activity and breast cancer risk by hormone receptor status: effective life periods and exercise intensity
Publication date
01-11-2010
Published in
Cancer Causes & Control / Issue 11/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9605-7

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