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01-05-2012 | Original paper

Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women

Authors: Michiko Tsuji, Yuya Tamai, Keiko Wada, Kozue Nakamura, Makoto Hayashi, Noriyuki Takeda, Keigo Yasuda, Chisato Nagata

Published in: Cancer Causes & Control | Issue 5/2012

Abtract

Objective

Endogenous sex hormones have been implicated in the etiology of breast cancer. Dietary factors such as fat, dietary fiber, soy isoflavones, and alcohol have been suggested to influence endogenous estrogen and other steroid hormone levels. We examined the relationship among these dietary factors and plasma sex hormone levels in premenopausal Japanese women.

Methods

We measured the plasma concentrations of estradiol, estrone, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin, a follicle-stimulating hormone, a luteinizing hormone, and prolactin among 393 premenopausal women who had regular menstrual cycles fewer than 40 days apart. The dietary intakes were estimated with a validated food frequency questionnaire.

Results

After controlling for age, BMI, phase of the menstrual cycle, number of births, age at first birth, history of breastfeeding, and smoking status, the saturated fat intake was significantly positively associated with total estradiol and free estradiol levels. Intakes of the other types of fat, dietary fiber, soy isoflavones, and alcohol were not significantly associated with levels of any hormone measured.

Conclusions

These data suggest that a high intake of saturated fat is associated with increased estradiol levels in premenopausal Japanese women. Saturated fat intake may have implications in the etiology of breast cancer.

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Title: Associations of intakes of fat, dietary fiber, soy isoflavones, and alcohol with levels of sex hormones and prolactin in premenopausal Japanese women
Authors: Michiko Tsuji
Yuya Tamai
Keiko Wada
Kozue Nakamura
Makoto Hayashi
Noriyuki Takeda
Keigo Yasuda
Chisato Nagata
Publication date: 01-05-2012
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 5/2012
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-012-9935-8

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Abtract

Objective

Methods

Results

Conclusions

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