Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Cancer Causes & Control
Published in: Cancer Causes & Control 12/2010

01-12-2010 | Original paper

Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women

Authors: Geoffrey C. Kabat, Mimi Kim, Jean Wactawski-Wende, Dorothy Lane, Lucile L. Adams-Campbell, Mia Gaudet, Marcia L. Stefanick, Mara Vitolins, Rowan T. Chlebowski, Sylvia Wassertheil-Smoller, Thomas E. Rohan

Published in: Cancer Causes & Control | Issue 12/2010

Login to get access

Abstract

Objective

To assess the association of recreational physical activity and anthropometric factors in relation to risk of ductal carcinoma in situ (DCIS) of the breast.

Methods

The association was examined in a cohort of 58,055 postmenopausal women participating in the Women’s Health Initiative (WHI) clinical trials, among whom 450 cases of DCIS were ascertained after a median follow-up of 8.0 years. Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).

Results

After adjustment for covariates, the hazard ratio for DCIS among women with ≥20 metabolic equivalent task-hours per week (MET-h/week) of total recreational physical activity compared to women who did not engage in any recreational physical activity (0 MET-h/week) was 0.97 (95% CI 0.70–1.34). Neither body mass index nor waist circumference was associated with risk. In addition, physical activity and anthropometric factors were not associated with risk of either high-grade or low-/moderate-grade DCIS.

Conclusions

Recreational physical activity and anthropometric factors showed no association with risk of DCIS in postmenopausal women in the WHI clinical trial.
Literature
1.
2.
Monninkhof EM, Elias SG, Vlems FA, van der Tweel I, Schuit AJ, Voskuil DW, van Leeuwen FE (2007) Physical activity and breast cancer: a systematic review. Epidemiology 18:137–157CrossRefPubMed
3.
World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. American Institute for Cancer Research, Washington, DC
4.
Neilson HK, Friedenreich CM, Brocton NT, Millikan RC (2009) Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research (review). Cancer Epidemiol Biomarkers Prev 18:11–27CrossRefPubMed
5.
McTiernan A, Kooperberg C, White E, Wilcox S, Coates R, Adams-Campbell LL, Woods N, Ockene J (2003) Recreational physical activity and the risk of breast cancer in postmenopausal women: the Women’s Health Initiative cohort study. JAMA 290:1331–1336CrossRefPubMed
6.
Morimoto LM, White E, Chen Z, Chlebowski RT, Hays J, Kuller L, Lopez AM, Manson J, Margolis KL, Muti PC, Stefanick ML, McTiernan A (2002) Obesity, body size, and risk of postmenopausal breast cancer: the Women’s Health Initiative (United States). Cancer Causes Control 13:741–751CrossRefPubMed
7.
Patel AV, Press MF, Meeske K et al (2003) Lifetime recreational physical activity and risk of breast carcinoma in situ. Cancer 98:2161–2169CrossRefPubMed
8.
Sprague BL, Trentham-Dietz A, Newcomb PA, Titus-Ernstoff L, Hampton JM, Egan KM (2007) Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer. Cancer Epidemiol Biomarkers Prev 16:236–243CrossRefPubMed
9.
Schmidt ME, Steindorf K, Mutschelknauss E et al (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective life periods. Cancer Epidemiol Biomarkers Prev 17:3402–3410CrossRefPubMed
10.
Dallal CM, Sullivan-Halley J, Ross RK et al (2007) Long-term recreational physical activity and risk of invasive and in situ breast cancer. Arch Int Med 167:408–415CrossRef
11.
12.
Weiss HA, Brinton LA, Brogan D, Coates RJ, Gammon MD, Malone KE, Schoenberg JB, Swanson CA (1996) Epidemiology of in situ and invasive breast cancer in women aged under 45. Brit J Cancer 73:1298–1305PubMed
13.
Trentham-Dietz A, Newcomb PA, Storer BE, Remington PL (2000) Risk factors for carcinoma in situ of the breast. Cancer Epidemiol Biomarkers Prev 9:697–703PubMed
14.
Trentham-Dietz A, Nichols HB, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA (2007) Cigarette smoking and risk of breast carcinoma in situ. Epidemiology 18:629–638CrossRefPubMed
15.
Allegra CJ, Aberle DR, Ganschow P et al (2010) National Institutes of Health State-of-the-Science conference statement: diagnosis and management of ductal carcinoma in situ September 22–24, 2009. J Natl Cancer Inst 102(3):161–169CrossRefPubMed
16.
Virnig BA, Tuttle TM, Shamlilyan T, Kane RL (2010) Ductal carcinoma in situ of the breast: a systemic review of incidence, treatment, and outcomes. J Natl Cancer Inst 102(3):170–178CrossRefPubMed
17.
Graff S (2010) Ductal carcinoma in situ: should the name be changed? J Natl Cancer Inst 102(1):6–8CrossRefPubMed
18.
The Women’s Health Initiative Study Group (1998) Design of the Women’s Health Initiative Clinical Trial and observational study. Control Clin Trials 19:61–109CrossRef
19.
Anderson GL, Manson J, Wallace R, Lund B, Hall D, Davis S, Shumaker S, Wang CY, Stein E, Prentice RL (2003) Implementation of the Women’s Health Initiative study design. Ann Epidemiol 13:S5–S17CrossRefPubMed
20.
Langer RD, White E, Lewis CE, Kotchen JM, Hendrix SL, Trevisan M (2003) The Women’s Health Initiative Observational Study: baseline characteristics of participants and reliability of baseline measures. Ann Epidemiol 13:S107–S121CrossRefPubMed
21.
Curb JD, McTiernan A, Heckbert SR, Kooperberg C, Stanford J, Nevitt M, Johnson KC, Proulx-Burns L, Pastore L, Criqui M, Daugherty S (2003) Outcomes ascertainment and adjudication methods in the Women’s Health Initiative. Ann Epidemiol 13(9 Suppl):S122–S128CrossRefPubMed
22.
Chlebowski RT, Hendrix SL, Langer RD et al (2003) Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women’s Health Initiative Randomized Trial. JAMA 289:3243–3253CrossRefPubMed
23.
Prentice RL, Caan B, Chlebowski RT et al (2006) Low-fat dietary pattern and risk of invasive breast cancer: the WOMEN’S health initiative randomized controlled dietary modification trial. JAMA 295:629–642CrossRefPubMed
24.
Kuerer HM, Albarracin CT, Yang WT et al (2008) Ductal carcinoma in situ: state of the science and roadmap to advance the field. J Clin Oncol 27:279–288CrossRefPubMed
25.
Sontag L, Axelrod DE (2005) Evaluation of pathways for progression of heterogeneous breast tumors. J Theor Biol 232:179–189CrossRefPubMed
26.
Dupont WD, Parl FF, Hartmann WH et al (1993) Breast cancer risk associated with proliferative breast disease and atypical hyperplasia. Cancer 71:1258–1265CrossRefPubMed
27.
Carter CL, Corle DK, Micozzi MS, Schatzkin A, Taylor PR (1988) A prospective study of the development of breast cancer in 16, 692 women with benign breast disease. Am J Epidemiol 128:467–477PubMed
28.
Lakhani SR, Chaggar R, Davies S et al (1999) Genetic alterations in ‘normal’ luminal and myoepithelial cells of the breast. J Pathol 189:496–503CrossRefPubMed
29.
Ainsworth BE, Haskell WL, Leon AS et al (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25:71–80CrossRefPubMed
Metadata
Title
Recreational physical activity, anthropometric factors, and risk of ductal carcinoma in situ of the breast in a cohort of postmenopausal women
Authors
Geoffrey C. Kabat
Mimi Kim
Jean Wactawski-Wende
Dorothy Lane
Lucile L. Adams-Campbell
Mia Gaudet
Marcia L. Stefanick
Mara Vitolins
Rowan T. Chlebowski
Sylvia Wassertheil-Smoller
Thomas E. Rohan
Publication date
01-12-2010
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 12/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9637-z

Other articles of this Issue 12/2010

Cancer Causes & Control 12/2010 Go to the issue

Original paper

Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans

Original paper

Revision of comprehensive cancer control plans: experiences shared by three states

Original paper

Association between body mass index and mortality in patients with glioblastoma mutliforme

Original paper

A comparison of cancer screening practices in cancer survivors and in the general population: the Korean national health and nutrition examination survey (KNHANES) 2001–2007

Letter to the Editor

Association of facial skin aging and vitamin D levels in middle-aged white women

Original paper

Exogenous sex hormone use and risk of meningioma: a population-based case–control study in Finland
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits