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Cancer Causes & Control
Published in: Cancer Causes & Control 12/2010

01-12-2010 | Original paper

Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans

Authors: Michelle K. McHugh, Sumesh Kachroo, Mei Liu, Anthony M. D’Amelio Jr., Qiong Dong, Waun Ki Hong, Anthony J. Greisinger, Margaret R. Spitz, Carol J. Etzel

Published in: Cancer Causes & Control | Issue 12/2010

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Abstract

Background

We investigated environmental and occupational exposures and smoking history (while controlling for demographics) in a population of Mexican–American lung cancer cases and controls from the Houston metropolitan area.

Methods

Data were collected between 1991 and 2005 as part of an on-going multi-racial/ethnic, lung cancer case–control study. Cases included 212 Mexican–American lung cancer cases from UT MD Anderson Cancer Center. Controls (n = 328) were recruited from Houston’s largest multispecialty group practice and frequency matched to the cases by age (±5 years), sex, and ethnicity. Environmental and occupational factors were analyzed and odds ratios and 95% confidence intervals were calculated using logistic regression.

Results

We detected elevated risks of lung cancer associated with pesticide exposure and found conventional and antimicrobial (e.g., sterilizers, disinfectants, antiseptics) pesticides were associated with an increased risk of lung cancer in Mexican–Americans (conventional pesticides and antimicrobial pesticides combined: OR = 1.80, 95% CI 1.13–2.86; conventional pesticides: OR = 2.05, 95% CI 1.23–2.39; antimicrobial pesticides: OR = 2.48, 95% CI 1.46–4.21).

Conclusions

Although we found over a two-fold increased risk of lung cancer among Mexican–Americans for pesticides, we could not identify individual pesticides. Our findings are an important preliminary step in identifying factors that are specifically associated with lung cancer risk among Mexican Americans.
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Metadata
Title
Assessing environmental and occupational risk factors for lung cancer in Mexican–Americans
Authors
Michelle K. McHugh
Sumesh Kachroo
Mei Liu
Anthony M. D’Amelio Jr.
Qiong Dong
Waun Ki Hong
Anthony J. Greisinger
Margaret R. Spitz
Carol J. Etzel
Publication date
01-12-2010
Publisher
Springer Netherlands
Published in
Cancer Causes & Control / Issue 12/2010
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-010-9635-1

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